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Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis.

Abstract：

:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). These B-lymphocyte and immunoglobulin-deficient rats failed to develop clinical or histological evidence of EAE when sensitized with either whole spinal cord or purified BP. That some T-cell functions of these suppressed animals were not altered was seen by their ability to respond normally to PHA and to reject tissue allografts. The results would suggest that B-cell function (immunoglobulin-antibody production) is essential for the induction of EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Willenborg DO,Prowse SJ

doi

10.1016/0165-5728(83)90001-2

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

99-109

issue

2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(83)90001-2

journal_volume

5

pub_type

杂志文章

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