Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.

abstract：:Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correla...

journal_title：Journal of neuroimmunology

authors： Baranowska-Bik A,Kochanowski J,Uchman D,Wolinska-Witort E,Kalisz M,Martynska L,Baranowska B,Bik W

更新日期：2013-10-15 00:00:00

abstract：:Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

journal_title：Journal of neuroimmunology

authors： Almolda B,González B,Castellano B

更新日期：2010-06-01 00:00:00

abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

journal_title：Journal of neuroimmunology

authors： Nickola TJ,Ignatowski TA,Spengler RN

更新日期：2000-07-10 00:00:00

abstract：:Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3...

journal_title：Journal of neuroimmunology

authors： Kyrkanides S,O'Banion MK,Whiteley PE,Daeschner JC,Olschowka JA

更新日期：2001-10-01 00:00:00

abstract：:Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

journal_title：Journal of neuroimmunology

authors： Fields KL,Yen SH

更新日期：1985-06-01 00:00:00

abstract：:This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without tr...

journal_title：Journal of neuroimmunology

authors： Sadowska-Bartosz I,Adamczyk-Sowa M,Gajewska A,Bartosz G

更新日期：2014-01-15 00:00:00

abstract：:Antiphospholipid syndrome (APS), an autoantibody mediated disease, is characterized by presence of antibodies against the proteins bound to the phospholipid membranes. The antibodies are predominantly formed against beta-2-glycoprotein I (b2GPI) which is considered pathogenic, but presence of lupus anticoagulant is a ...

journal_title：Journal of neuroimmunology

authors： Aneja J,Kuppili PP,Paul K,Panda S,Purohit A

更新日期：2020-06-15 00:00:00

abstract：:Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobi...

journal_title：Journal of neuroimmunology

authors： Bansi J,Koliamitra C,Bloch W,Joisten N,Schenk A,Watson M,Kool J,Langdon D,Dalgas U,Kesselring J,Zimmer P

更新日期：2018-01-15 00:00:00

abstract：:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which i...

journal_title：Journal of neuroimmunology

authors： Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

更新日期：2005-10-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

journal_title：Journal of neuroimmunology

authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

更新日期：2019-02-15 00:00:00

abstract：:Pathogenic autoreactive T cells can be targeted by T cell vaccination (TCV), a procedure in which patients are immunized with autologous attenuated pathogenic T cells. We reported previously that TCV with myelin basic protein (MBP) reactive T cell clones in multiple sclerosis (MS) patients induced T cell immune respon...

journal_title：Journal of neuroimmunology

authors： Hermans G,Medaer R,Raus J,Stinissen P

更新日期：2000-01-03 00:00:00

abstract：:Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN-β, compared with healthy controls. In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th...

journal_title：Journal of neuroimmunology

authors： Monteiro A,Rosado P,Rosado L,Fonseca AM,Paiva A

更新日期：2020-02-15 00:00:00

abstract：:TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...

journal_title：Journal of neuroimmunology

authors： Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

更新日期：2005-11-01 00:00:00

abstract：:The expression of intercellular adhesion molecule-1 (ICAM-1) by human cerebral endothelium was studied in primary cultures of human brain microvessel endothelial cells following treatment with bacterial lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gam...

journal_title：Journal of neuroimmunology

authors： Wong D,Dorovini-Zis K

更新日期：1992-07-01 00:00:00

abstract：:Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

journal_title：Journal of neuroimmunology

authors： Michalovicz LT,Lally B,Konat GW

更新日期：2015-08-15 00:00:00

abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

journal_title：Journal of neuroimmunology

authors： Marra S,Burnett M,Hoffman-Goetz L

更新日期：2005-01-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) establishes a persistent infection in the central nervous system (CNS). To examine the role of type I interferon (IFN-I)-mediated signals in TMEV infection, mice lacking a subunit of the type I IFN receptor (IFN-IR KO mice) were utilized. In contrast to wild type mice, I...

journal_title：Journal of neuroimmunology

authors： Jin YH,Hou W,Kim SJ,Fuller AC,Kang B,Goings G,Miller SD,Kim BS

更新日期：2010-09-14 00:00:00

abstract：:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricul...

journal_title：Journal of neuroimmunology

authors： Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

更新日期：1989-09-01 00:00:00

abstract：:Chemokines are critical mediators of immune cell entry into the central nervous system (CNS), as occurs in neuroinflammatory disease such as multiple sclerosis. Chemokines are also implicated in the immune response to viral infections. Many viruses encode proteins that mimic or block chemokine actions, in order to eva...

journal_title：Journal of neuroimmunology

authors： Millward JM,Holst PJ,Høgh-Petersen M,Thomsen AR,Christensen JP,Owens T

更新日期：2010-07-27 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:Methylene blue (MB) is an effective neuroprotectant in many neurological disorders. AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1 (SIRT1) plays a crucial role in maintaining inflammatory responses and shows a synergistic effect on cell homeostasis. We investigated the effect...

journal_title：Journal of neuroimmunology

authors： Wang J,Zhao C,Kong P,Bian G,Sun Z,Sun Y,Guo L,Li B

更新日期：2016-10-15 00:00:00

abstract：:Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...

journal_title：Journal of neuroimmunology

authors： O'Shannessy DJ,Ilyas AA,Dalakas MC,Mendell JR,Quarles RH

更新日期：1986-04-01 00:00:00

abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

journal_title：Journal of neuroimmunology

authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

更新日期：1998-06-15 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

journal_title：Journal of neuroimmunology

authors： Mehl VS,Lang RW

更新日期：1984-08-01 00:00:00

abstract：:In multiple sclerosis, infiltrating T lymphocytes and perivascular microglia may initiate demyelinating lesions, but a role for antibody and complement in the ensuing inflammatory damage to myelin and oligodendrocytes is likely. In most tissues, ubiquitously expressed complement regulatory proteins prevent autologous ...

journal_title：Journal of neuroimmunology

authors： Scolding NJ,Morgan BP,Compston DA

更新日期：1998-04-01 00:00:00

abstract：:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxi...

journal_title：Journal of neuroimmunology

authors： De la Fuente M,Del Río M,Medina S

更新日期：2001-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

journal_title：Journal of neuroimmunology

authors： Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

更新日期：2018-05-15 00:00:00

abstract：:Patients with small-cell carcinoma of the lung and paraneoplastic encephalomyelitis develop antibodies (anti-Hu) against HuD, a member of a family of neuronal specific RNA-binding proteins, which are also expressed by the tumor. In order to determine if the human HuD paraneoplastic antigen shares immunogenic regions b...

journal_title：Journal of neuroimmunology

authors： Sillevis Smitt P,Manley G,Dalmau J,Posner J

更新日期：1996-12-01 00:00:00

abstract：:Peripheral circulating cytokines are involved in immune to brain communication and systemic inflammation is considered a risk factor for flaring up the symptoms in most neurodegenerative diseases. We induced both central inflammatory demyelinating lesion, and systemic inflammation with an interleukin-1β expressing ade...

journal_title：Journal of neuroimmunology

authors： Murta V,Farías MI,Pitossi FJ,Ferrari CC

更新日期：2015-01-15 00:00:00