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Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.

Abstract：

:Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correlation with IL-6, IL-10 and TNFα, we compared 20 MS individuals with 27 healthy controls. In MS, a decrease in PACAP-38 in CSF and a decrease in plasma IL-6 concentration were seen. A positive correlation between plasma VIP and plasma IL-6 was identified. We conclude that VIP and PACAP may influence the course of MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Baranowska-Bik A,Kochanowski J,Uchman D,Wolinska-Witort E,Kalisz M,Martynska L,Baranowska B,Bik W

doi

10.1016/j.jneuroim.2013.08.012

subject

Has Abstract

pub_date

2013-10-15 00:00:00

pages

159-61

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00233-6

journal_volume

263

pub_type

杂志文章

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