当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > A subset of Schwann cells in peripheral nerves contain a 50-kDa protein antigenically related to astrocyte intermediate filaments.

A subset of Schwann cells in peripheral nerves contain a 50-kDa protein antigenically related to astrocyte intermediate filaments.

Abstract：

:Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teased nerve preparations antigen-positive cells appeared to be the Schwann cells that surround small diameter, unmyelinated axons. Absorption of the antiserum with purified rat spinal cord 50-kDa protein or with bovine splenic nerve cytoskeletal extract blocked the reaction with CNS astrocyte processes or with PNS nerve fibers. Immunoblots of cytoskeletal preparations of bovine splenic nerve or rat sciatic nerve showed that the antigen from peripheral nerves comigrated at 50 kDa with antigen from bovine or rat spinal cord or cultured rat astrocytes. The CNS and PNS 50-kDa proteins from bovine tissues were subjected to limited digestion with Staphylococcus aureus protease V8. After separation on SDS-gels, antigenic peptides were detected by immunoblotting. The pattern of antigenic peptides for the CNS and PNS proteins were identical. We conclude that Schwann cells associated with nonmyelinated axons contain a cytoskeletal protein that is the same size and has the same peptide map as the major structural protein of astrocyte intermediate filaments.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Fields KL,Yen SH

doi

10.1016/s0165-5728(85)80070-9

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

311-30

issue

4-6

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(85)80070-9

journal_volume

8

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Microglial cell activation in demyelinating canine distemper lesions.

    abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.05.001

    authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

    更新日期：2004-08-01 00:00:00

  • Band 1 and voltage-sensitive Na+ channels are not codistributed in cultured rodent neuronal cells.

    abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90028-x

    authors： Akeson R,Graham K

    更新日期：1981-09-01 00:00:00

  • EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    abstract：:In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.09.007

    authors： Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

    更新日期：2013-11-15 00:00:00

  • Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells.

    abstract：:Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF,...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.09.018

    authors： Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

    更新日期：2006-02-01 00:00:00

  • Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.

    abstract：:The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-5728(98)00058-7

    authors： Karandikar NJ,Vanderlugt CL,Bluestone JA,Miller SD

    更新日期：1998-08-14 00:00:00

  • Relationships among neurotransmitters, cytokines and cognitive performance for individuals with hepatitis C achieving sustained virologic response: A pilot study.

    abstract：:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before an...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jneuroim.2019.577022

    authors： Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZM

    更新日期：2019-10-15 00:00:00

  • Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model.

    abstract：:Carbon nantotubes (CNTs) are emerging as a new family of nanovectors for drug and gene delivery into biological systems. To evaluate potential application of this technology for brain tumor therapy, we studied uptake and toxicity of multi-walled CNTs (MWCNTs) in the GL261 murine intracranial glioma model. Within 24 h ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.12.006

    authors： VanHandel M,Alizadeh D,Zhang L,Kateb B,Bronikowski M,Manohara H,Badie B

    更新日期：2009-03-31 00:00:00

  • Differential immune responses in mice with left- and right-turning preference.

    abstract：:Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00222-7

    authors： Kim D,Carlson JN,Seegal RF,Lawrence DA

    更新日期：1999-01-01 00:00:00

  • Comparative binding of murine and human monoclonal antibodies reacting with myelin-associated glycoprotein to myelin and human lymphocytes.

    abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90118-4

    authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

    更新日期：1987-07-01 00:00:00

  • Native versus deglycosylated IgM in anti-MAG neuropathy: Correlation with clinical status - Study of 10 cases.

    abstract：BACKGROUND/PURPOSE:In anti-myelin associated glycoprotein (anti-MAG) neuropathies, there is evidence that anti-MAG antibodies are pathogenic but numerous studies report the absence or a weak correlation between the titers of these antibodies and disease course. In this study we assessed the relationships between MAG an...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.577094

    authors： Neil J,Choumet V,Beadon K,Delmont E,Ghillani P,Boucraut J,Musset L,Léger JM

    更新日期：2020-02-15 00:00:00

  • Monoclonal and polyclonal antibody responses to the myelin basic protein epitope present in human urine.

    abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90162-7

    authors： Whitaker JN,McKeehan A,Freeman DW

    更新日期：1994-06-01 00:00:00

  • Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis.

    abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90001-2

    authors： Willenborg DO,Prowse SJ

    更新日期：1983-10-01 00:00:00

  • Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients.

    abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(90)90005-8

    authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

    更新日期：1990-03-01 00:00:00

  • Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

    abstract：:Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.04.012

    authors： Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

    更新日期：2005-08-01 00:00:00

  • Muscarinic cholinergic receptor subtypes in the pigeon bursa of Fabricius: a radioligand binding and autoradiographic study.

    abstract：:The pharmacological profile and the anatomical localisation of muscarinic cholinergic receptor subtypes were studied in the pigeon bursa of Fabricius, using radioligand binding and autoradiographic techniques with [3H]quinuclidinyl benzilate (QNB) as a ligand. [3H]QNB was specifically bound to sections of bursa of Fab...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(96)00012-4

    authors： Ricci A,Bronzetti E,Felici L,Ciriaco E,Vega JA,Germanà G

    更新日期：1996-05-01 00:00:00

  • Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis.

    abstract：:Axonal injury is the major cause of disability in patients with multiple sclerosis (MS), but the mechanisms leading to axonal damage are poorly understood. Oligoclonal IgM against lipids predicts an aggressive disease course in MS; however, the antigen that elicits the immune response has not yet been identified. We s...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.03.013

    authors： Beltrán E,Hernández A,Lafuente EM,Coret F,Simó-Castelló M,Boscá I,Pérez-Miralles FC,Burgal M,Casanova B

    更新日期：2012-06-15 00:00:00

  • Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

    abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.05.012

    authors： Tsunoda I,Libbey JE,Fujinami RS

    更新日期：2007-08-01 00:00:00

  • MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages.

    abstract：:Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3 signals ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577217

    authors： Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

    更新日期：2020-06-15 00:00:00

  • Evidence that mouse astrocytes may be derived from the radial glia. An immunohistochemical study of the cerebellum in the normal and reeler mouse.

    abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(85)80009-6

    authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

    更新日期：1985-07-01 00:00:00

  • Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.

    abstract：:The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphoc...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00012-0

    authors： Windhagen A,Maniak S,Gebert A,Ferger I,Heidenreich F

    更新日期：1999-04-01 00:00:00

  • Human immunodeficiency virus type-1 Nef protein induces blood-brain barrier disruption in the rat: role of matrix metalloproteinase-9.

    abstract：:We recently showed that MMP-9 activity was detectable in the cerebrospinal fluid (CSF) of about half of neurologically symptomatic HIV-infected patients. Using an experimental animal model, we detected MMP-9 activity in CSF samples from rats that had been injected intracisternally with recombinant HIV-1 Nef protein, b...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00170-8

    authors： Sporer B,Koedel U,Paul R,Kohleisen B,Erfle V,Fontana A,Pfister HW

    更新日期：2000-01-24 00:00:00

  • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correla...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.08.012

    authors： Baranowska-Bik A,Kochanowski J,Uchman D,Wolinska-Witort E,Kalisz M,Martynska L,Baranowska B,Bik W

    更新日期：2013-10-15 00:00:00

  • Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid.

    abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(90)90152-d

    authors： Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

    更新日期：1990-09-01 00:00:00

  • Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection.

    abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90040-4

    authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

    更新日期：1989-04-01 00:00:00

  • γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis.

    abstract：:The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It s...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2019.02.009

    authors： Zarobkiewicz MK,Kowalska W,Roliński J,Bojarska-Junak AA

    更新日期：2019-05-15 00:00:00

  • Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis.

    abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00309-5

    authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

    更新日期：2001-06-01 00:00:00

  • Optic neuritis is associated with myelin basic protein and proteolipid protein reactive cells producing interferon-gamma, interleukin-4 and transforming growth factor-beta.

    abstract：:Studies on patients with monosymptomatic optic neuritis (ON) should give opportunities to identify features typical for early multiple sclerosis (MS). There are increased T and B cell responses to the myelin components myelin basic protein (MBP) and proteolipid protein (PLP) in both ON and MS, but there is little info...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90175-9

    authors： Link J,Söderström M,Kostulas V,Olsson T,Höjeberg B,Ljungdahl A,Link H

    更新日期：1994-01-01 00:00:00

  • Comparison of T8+ cell-mediated suppressor and cytotoxic functions in multiple sclerosis.

    abstract：:Patients with progressive multiple sclerosis (MS) and controls were compared with regard to: (a) in vitro pokeweed mitogen (pwm)-induced IgG secretion, as an indirect measure of T8+ cell-mediated suppressor function; (b) alloantigen-directed cytotoxic activity, a predominantly T8+ cell-mediated function. The MS group ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(86)80005-4

    authors： Antel JP,Nicholas MK,Bania MB,Reder AT,Arnason BG,Joseph L

    更新日期：1986-09-01 00:00:00

  • Enhanced DNA synthesis of human glial cells exposed to human leukocyte products.

    abstract：:DNA synthesis was studied in primary glial cell cultures derived from adult human non-neoplastic and neoplastic brain tissues. Enhanced DNA synthesis occurred in 5/5 non-neoplastic astrocyte, one oligodendroglioma, and 2/5 astrocytoma cultures after exposure to medium containing 1.25-12.5% supernatant fluid (SF) from ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(85)90005-0

    authors： Barna BP,Chou SM,Jacobs B,Ransohoff RM,Hahn JF,Bay JW

    更新日期：1985-12-01 00:00:00

  • Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice.

    abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00460-x

    authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

    更新日期：2002-01-01 00:00:00