Abstract:
:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before and after achieving sustained virologic response (SVR). Pre-SVR, elevated kynurenine was associated with increased immediate and delayed visual memory, whereas post-SVR the positive associations are between kynurenine and immediate and delayed verbal memory. TGF-B was consistently negatively associated with both immediate and delayed visual memory pre- and post-SVR. These concomitant changes may have important clinical relevance.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZMdoi
10.1016/j.jneuroim.2019.577022subject
Has Abstractpub_date
2019-10-15 00:00:00pages
577022eissn
0165-5728issn
1872-8421pii
S0165-5728(19)30325-Xjournal_volume
335pub_type
临床试验,杂志文章,多中心研究abstract::To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myeli...
journal_title:Journal of neuroimmunology
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abstract::The in vivo effects on the expression of adhesion molecules and on the adhesion between mononuclear cells and multiple sclerosis human brain endothelial cells (MS-HBECs) were investigated at the beginning of beta-IFN-1b treatment of MS patients. MS-HBECs were isolated from a surgical specimen obtained from an MS patie...
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abstract::High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic si...
journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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