Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions.

Abstract:

:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxis, phagocytosis, superoxide anion production, and the release of TNFalpha and IL-1beta) have been studied on cells from young (12+/-2 weeks), adult (24+/-2 weeks), mature (50+/-2 weeks) and old (72+/-2 weeks) BALB/c mice. The specificity of these actions was confirmed using two C-terminal fragments of NPY, and the intracellular messengers (protein kinase C and cAMP) involved in the action of the neuropeptide were also analyzed. The results show that the functions studied change with aging and that the effects of NPY on each function, which are carried out through specific receptors, as well as on intracellular pathway, differ depending on age, maintaining the immune functions at physiologically adequate levels in old animals.

journal_name

J Neuroimmunol

authors

De la Fuente M,Del Río M,Medina S

doi

10.1016/s0165-5728(01)00297-1

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

156-67

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572801002971

journal_volume

116

pub_type

杂志文章
  • Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo.

    abstract::We investigated the expression and production of the interleukin-1 receptor antagonist (IL-1ra) in three human glioblastoma cell lines (LN443, LN444, LN859). Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of IL-1ra mRNA transcripts in the three cell lines. These three cell lines a...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)90045-0

    authors: Tada M,Diserens AC,Desbaillets I,Jaufeerally R,Hamou MF,de Tribolet N

    更新日期:1994-03-01 00:00:00

  • Interactions between CD4+ T-cells and rat Schwann cells in vitro. 2. Cytotoxic effects of P2-specific CD4+ T-cell lines on Lewis rat Schwann cells.

    abstract::The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(92)90209-4

    authors: Argall KG,Armati PJ,Pollard JD,Bonner J

    更新日期:1992-09-01 00:00:00

  • Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

    abstract::Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscle's proteomi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2013.05.008

    authors: Gomez AM,Vanheel A,Losen M,Molenaar PC,De Baets MH,Noben JP,Hellings N,Martinez-Martinez P

    更新日期:2013-08-15 00:00:00

  • Effect of staphylococcal enterotoxin B injection on the development of experimental autoimmune encephalomyelitis: influence of cytokine and inducible nitric oxide synthase production.

    abstract::Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of Vbeta8 + T-lymphocytes were documented after myelin basic protein immuniza...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00024-7

    authors: Kuschnaroff LM,Overbergh L,Sefriouni H,Sobis H,Vandeputte M,Waer M

    更新日期:1999-10-29 00:00:00

  • Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis.

    abstract::We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)90131-7

    authors: Stevens DB,Gould KE,Swanborg RH

    更新日期:1994-04-01 00:00:00

  • Beta-adrenoceptor mediated surgery-induced production of pro-inflammatory cytokines in rat microglia cells.

    abstract::Immunological changes initiated by major operative injury may result in inflammatory responses in both peripheral and central nervous system, which may lead to organ dysfunction. Recent studies indicate that beta-adrenergic receptors (beta-ARs) may mediate production of pro-inflammatory cytokines in the brain. In the ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.04.006

    authors: Wang J,Li J,Sheng X,Zhao H,Cao XD,Wang YQ,Wu GC

    更新日期:2010-06-01 00:00:00

  • Monoclonal antibodies to central nervous system antigens.

    abstract::Thirty monoclonal antibodies produced by mouse hybrid myelomas which react with antigens in hamster or mouse nervous system tissues were derived. Using these antibodies as probes with indirect immunofluorescence and immunoperoxidase techniques, we can selectively identify by morphological criteria many of the structur...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(81)90019-9

    authors: Franko MC,Masters CL,Gibbs CJ Jr,Gajdusek DC

    更新日期:1981-12-01 00:00:00

  • Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity.

    abstract:OBJECTIVES:We previously found that antibodies in Tourette's syndrome (TS) patients' sera reacted with a 120 kDa protein from rat brain tissue. Here, we sought to identify this protein and determine if it was involved in TS pathogenesis. METHODS:The 120 kDa protein was identified using immunoprecipitation, Western blo...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2012.05.009

    authors: Yeh CB,Shui HA,Chu TH,Chen YA,Tsung HC,Shyu JF

    更新日期:2012-09-15 00:00:00

  • 2D immunomic approach for the study of IgG autoantibodies in the experimental model of multiple sclerosis.

    abstract::2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-im...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.10.004

    authors: Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

    更新日期:2011-03-01 00:00:00

  • The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.

    abstract::Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(89)90003-9

    authors: Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

    更新日期:1989-03-01 00:00:00

  • Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population.

    abstract::Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopme...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.09.019

    authors: Kapelski P,Skibinska M,Maciukiewicz M,Pawlak J,Permoda-Osip A,Twarowska-Hauser J

    更新日期:2015-08-15 00:00:00

  • Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain.

    abstract::Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced neuroinflammation which was cha...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.06.005

    authors: Xia MX,Ding X,Qi J,Gu J,Hu G,Sun XL

    更新日期:2014-08-15 00:00:00

  • Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein.

    abstract::Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(93)90268-4

    authors: Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

    更新日期:1993-04-01 00:00:00

  • The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

    abstract::Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to al...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2005.06.008

    authors: Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

    更新日期:2005-10-01 00:00:00

  • Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques.

    abstract::To find out whether rhesus macaque peripheral blood mononuclear cells (PBMCs) express mRNA for 5-HT receptors, blood samples from normal healthy rhesus monkeys were used to isolate PBMCs by Ficoll-paque density gradient centrifugation. Total RNA was extracted from MT-2 cells, Hut-78 cells, naive or phytohemagglutinin ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.05.016

    authors: Yang GB,Qiu CL,Zhao H,Liu Q,Shao Y

    更新日期:2006-09-01 00:00:00

  • Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice.

    abstract::Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2005.04.006

    authors: Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

    更新日期:2005-07-01 00:00:00

  • Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO.

    abstract::Dendritic cells are the critical mediators of various immune responses and are the first line of defense against any infection including HIV. They play a major role in harboring HIV and the subsequent infection of T cells and passage of virus through the blood-brain barrier (BBB). The recently discovered DC-specific, ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2004.08.040

    authors: Nair MP,Schwartz SA,Mahajan SD,Tsiao C,Chawda RP,Whitney R,Don Sykes BB,Hewitt R

    更新日期:2004-12-01 00:00:00

  • Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

    abstract::VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2007.05.012

    authors: Tsunoda I,Libbey JE,Fujinami RS

    更新日期:2007-08-01 00:00:00

  • Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.

    abstract::Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyeliti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2015.08.006

    authors: Li-ChunHsieh K,Schob S,Zeller MW,Pulli B,Ali M,Wang C,Chiou TT,Tsang YM,Lee PS,Stossel TP,Chen JW

    更新日期:2015-10-15 00:00:00

  • Tumour necrosis factor-alpha has few morphological effects within the dorsal columns of the spinal cord, in contrast to its effects in the peripheral nervous system.

    abstract::There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but there is no direct evidence that TNF can produce demyelination in the central nervous system (CNS). We demonstrate here that single injections of TNF into the dors...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(00)00213-7

    authors: Hall SM,Redford EJ,Smith KJ

    更新日期:2000-07-01 00:00:00

  • Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.

    abstract::Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx int...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(00)00183-1

    authors: Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

    更新日期:2000-06-01 00:00:00

  • alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

    abstract::The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The L...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2003.12.017

    authors: Godbout JP,Berg BM,Kelley KW,Johnson RW

    更新日期:2004-04-01 00:00:00

  • Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis.

    abstract::The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-su...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2007.09.019

    authors: Sakthivel P,Ramanujam R,Wang XB,Pirskanen R,Lefvert AK

    更新日期:2008-01-01 00:00:00

  • TNF and sTNFR1/2 plasma levels in ALS patients.

    abstract::The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2007.10.028

    authors: Cereda C,Baiocchi C,Bongioanni P,Cova E,Guareschi S,Metelli MR,Rossi B,Sbalsi I,Cuccia MC,Ceroni M

    更新日期:2008-02-01 00:00:00

  • A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis.

    abstract::Aberrant activation of calpain plays a key role in the pathophysiology of several neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in EAE and is significantly elevated in the white matter of patients with multiple sclerosis, thus calpain inhibition could be a target for therapeutic ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.08.005

    authors: Hassen GW,Feliberti J,Kesner L,Stracher A,Mokhtarian F

    更新日期:2006-11-01 00:00:00

  • Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.

    abstract::After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2003.10.049

    authors: Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

    更新日期:2004-01-01 00:00:00

  • Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

    abstract::Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.01.015

    authors: Young EE,Sieve AN,Vichaya EG,Carcoba LM,Young CR,Ambrus A,Storts R,Welsh CJ,Meagher MW

    更新日期:2010-03-30 00:00:00

  • Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids.

    abstract::To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)00140-j

    authors: Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

    更新日期:1995-02-01 00:00:00

  • Wallerian degeneration induces Ia-antigen expression in the rat brain.

    abstract::Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(89)90132-x

    authors: Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

    更新日期:1989-12-01 00:00:00

  • Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

    abstract::Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.01.002

    authors: Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

    更新日期:2014-03-15 00:00:00