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Myelin reactive T cells after T cell vaccination in multiple sclerosis: cytokine profile and depletion by additional immunizations.

Abstract：

:Pathogenic autoreactive T cells can be targeted by T cell vaccination (TCV), a procedure in which patients are immunized with autologous attenuated pathogenic T cells. We reported previously that TCV with myelin basic protein (MBP) reactive T cell clones in multiple sclerosis (MS) patients induced T cell immune responses, resulting in a clonal depletion of MBP reactive T cells in all patients. Five years after TCV, MBP reactive T cells were observed in five out of nine MS patients. These clones had a different clonal origin from those isolated before vaccination. We have studied the cytokine profile, cytotoxicity and epitope specificity of these reappearing clones. Our data indicate that the clones express similar effector functions as those isolated before TCV, suggesting that they also could play a pathogenic role in the disease. We demonstrated that these clones can be depleted by an additional sequence of immunizations. These findings may be relevant to other T cell targeted immunotherapies for MS and other autoimmune diseases.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hermans G,Medaer R,Raus J,Stinissen P

doi

10.1016/s0165-5728(99)00157-5

subject

Has Abstract

pub_date

2000-01-03 00:00:00

pages

79-84

issue

1

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(99)00157-5

journal_volume

102

pub_type

临床试验,杂志文章

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