Anti-C1q autoantibodies in patients with neuromyelitis optica spectrum disorders.

abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

journal_title：Journal of neuroimmunology

authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

更新日期：1990-03-01 00:00:00

abstract：:To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with ...

journal_title：Journal of neuroimmunology

authors： Ogata H,Isobe N,Zhang X,Yamasaki R,Fujii T,Machida A,Morimoto N,Kaida K,Masuda T,Ando Y,Kuwahara M,Kusunoki S,Nakamura Y,Matsushita T,Kira JI

更新日期：2020-02-15 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this study aimed to directly investigate antigen-dependent clonal T cell expansion after experimental brain ischemia using spe...

journal_title：Journal of neuroimmunology

authors： Liesz A,Karcher S,Veltkamp R

更新日期：2013-04-15 00:00:00

abstract：:In this report, the role of STAT4 and local production of interleukin (IL)-12 in the central nervous system (CNS) were examined during experimental vesicular stomatitis virus (VSV) encephalitis. We have previously shown that IL-12 treatment is beneficial both in vitro and in vivo during experimental VSV infection. Thi...

journal_title：Journal of neuroimmunology

authors： Chesler DA,Reiss CS

更新日期：2002-10-01 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disease that could be triggered by a viral infection. Coronaviruses induce an MS-like disease in rodents, are neuroinvasive in humans and can infect primary cultures of human astrocytes and microglia. Infection of the human astrocytic cell line U-373MG by the...

journal_title：Journal of neuroimmunology

authors： Edwards JA,Denis F,Talbot PJ

更新日期：2000-08-01 00:00:00

abstract：:Naive Th cells obtained from OVA(323-339)-specific DO11.10 TCR-Tg mice did not express preproenkephalin (PPE) mRNA. However, culture of naive Th cells with OVA(323-339) peptide (OVA-pep) plus IL-2 under Th2-inducing conditions for 7 days resulted in an induction of PPE mRNA. The PPE mRNA was also induced by culturing ...

journal_title：Journal of neuroimmunology

authors： Yahata T,Yahata C,Ohta A,Sekimoto M,Kitamura H,Iwakabe K,Habu S,Azuma S,Nakui M,Sato M,Koda T,Nishimura T

更新日期：2000-06-26 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflam...

journal_title：Journal of neuroimmunology

authors： Enders U,Toyka KV,Hartung HP,Gold R

更新日期：1997-06-01 00:00:00

abstract：:We studied the effects of combination treatment with an anti-inflammatory agent, interferon (IFN)-beta, and a putative neuroprotective agent, an estrogen receptor (ER)-beta ligand, during EAE. Combination treatment significantly attenuated EAE disease severity, preserved axonal densities in spinal cord, and reduced CN...

journal_title：Journal of neuroimmunology

authors： Du S,Sandoval F,Trinh P,Voskuhl RR

更新日期：2010-02-26 00:00:00

abstract：:Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and ...

journal_title：Journal of neuroimmunology

authors： Mantegazza R,Bernasconi P,Baggi F,Spreafico R,Ragona F,Antozzi C,Bernardi G,Granata T

更新日期：2002-10-01 00:00:00

abstract：:The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, ...

journal_title：Journal of neuroimmunology

authors： Hebron M,Peyton M,Liu X,Gao X,Wang R,Lonskaya I,Moussa CE

更新日期：2017-10-15 00:00:00

abstract：:Three monoclonal antibodies reactive with human myelin basic protein have been used to develop immunoradiometric assays for this protein. Clone 1, a mouse IgG2a, is reactive with an epitope in the region 129-138. Clone 2, a mouse IgG1, is reactive with the region 119-131. Clone 12, a rat IgG, is reactive with the regi...

journal_title：Journal of neuroimmunology

authors： Groome NP,Dawkes A,Gales M,Hruby S,Alvord EC Jr

更新日期：1986-10-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma agonist pioglitazone is FDA-approved for treatment of type-2 diabetes due to insulin sensitizing effects. However pioglitazone has anti-inflammatory and neuroprotective effects, reduces glial and T-cell activation, and reduces signs in an animal model of multiple sc...

journal_title：Journal of neuroimmunology

authors： Kaiser CC,Shukla DK,Stebbins GT,Skias DD,Jeffery DR,Stefoski D,Katsamakis G,Feinstein DL

更新日期：2009-06-25 00:00:00

abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

journal_title：Journal of neuroimmunology

authors： Paciotti GF,Skwerer RG,Tamarkin L

更新日期：1987-10-01 00:00:00

abstract：:To test the hypothesis of an altered central nervous system influence upon the immune system of Down's syndrome (DS) patients and in order to establish a peripheral biological marker of neuroimmune deficit, we have studied the characteristics of the beta 2-adrenergic receptor (B2AR) system in peripheral blood monocyte...

journal_title：Journal of neuroimmunology

authors： Morale MC,Batticane N,Cioni M,Marchetti B

更新日期：1992-06-01 00:00:00

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00

abstract：:Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neur...

journal_title：Journal of neuroimmunology

authors： Guasp M,Solà-Valls N,Martínez-Hernández E,Gil MP,González C,Brieva L,Saiz A,Dalmau J,Graus F,Ariño H

更新日期：2016-11-15 00:00:00

abstract：:Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in...

journal_title：Journal of neuroimmunology

authors： Kato S,Tsuzuki Y,Hokari R,Okada Y,Miyazaki J,Matsuzaki K,Iwai A,Kawaguchi A,Nagao S,Itoh K,Suzuki H,Nabeshima T,Miura S

更新日期：2005-04-01 00:00:00

abstract：:The hypothesis of an immune dysfunction in autism spectrum disorders has previously been put forward without, however, compelling evidence of a direct relation to its etiology or pathogenesis. To further understand if autoimmunity could play a significant role in autism, we analyzed autoantibody repertoires to brain t...

journal_title：Journal of neuroimmunology

authors： Silva SC,Correia C,Fesel C,Barreto M,Coutinho AM,Marques C,Miguel TS,Ataide A,Bento C,Borges L,Oliveira G,Vicente AM

更新日期：2004-07-01 00:00:00

abstract：:We investigated the effects of interferon beta-1a (IFN beta-1a) on specific response towards two immunodominant MBP peptides and on global production of IgG. We evaluated 54 sera from multiple sclerosis (MS) patients at baseline and 1 year after treatment. We did not observe any modification of immune response to the ...

journal_title：Journal of neuroimmunology

authors： Dubucquoi S,de Seze J,Lefranc D,Almeras L,Dutoit V,Prin L,Vermersch P

更新日期：2002-08-01 00:00:00

abstract：:Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with...

journal_title：Journal of neuroimmunology

authors： Poli L,De Giuli V,Piazza F,Volonghi I,Bigliardi G,Vallone S,Nichelli PF,Gasparotti R,Zini A,Padovani A,Pezzini A

更新日期：2020-01-15 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by communication deficits, impaired social interactions, and restricted stereotypical behaviors. Several immune cells are associated with immune dysfunction in ASD; however, IL-31 has not been explored in ASD. This study aims to ...

journal_title：Journal of neuroimmunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alsaad AMS,Assiri MA,Al-Mazroua HA,Attia SM

更新日期：2020-12-15 00:00:00

abstract：:Activation states of immune cells (among them, the so-called pro- or anti-inflammatory states) influence the pathogenesis of multiple sclerosis (MS). The neuropeptide calcitonin gene-related peptide (CGRP) can exert a pro- or anti-inflammatory role in a context-dependent manner. In mice CGRP was found to attenuate the...

journal_title：Journal of neuroimmunology

authors： Rossetti I,Zambusi L,Finardi A,Bodini A,Provini L,Furlan R,Morara S

更新日期：2018-10-15 00:00:00

abstract：:Microglial cells in the healthy adult brain possess a characteristic ramified morphology with multiple branched processes, small somata and down-regulated inflammatory properties. In contrast, microglial cells isolated from new-born rat brain inevitably show a non-ramified amoeboid phenotype, which is observed in vivo...

journal_title：Journal of neuroimmunology

authors： Wollmer MA,Lucius R,Wilms H,Held-Feindt J,Sievers J,Mentlein R

更新日期：2001-04-02 00:00:00

abstract：:The present investigations sought to determine whether the ventral tegmental area (VTA), basolateral amygdala (BLA), and nucleus accumbens shell (NAC) comprise a circuitry that mediates heroin-induced conditioned immunomodulation. Rats were given conditioning trials in which they received an injection of heroin upon p...

journal_title：Journal of neuroimmunology

authors： Szczytkowski JL,Fuchs RA,Lysle DT

更新日期：2011-08-15 00:00:00

abstract：:To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

journal_title：Journal of neuroimmunology

authors： Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

更新日期：2011-09-15 00:00:00

abstract：:In previous work on sigma (sigma) receptors, we established a hybridoma cell line, 10G9, producing a monoclonal anti-idiotypic antibody (anti-Id mAb) to the monoclonal and anti-haloperidol antibody. The anti-Id mAb showed specific binding affinity to sigma receptors in immunoprecipitation and competition experiments. ...

journal_title：Journal of neuroimmunology

authors： Kobayashi T,Togashi S,Itoh N,Kumanishi T

更新日期：1995-03-01 00:00:00

abstract：:A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the...

journal_title：Journal of neuroimmunology

authors： Fu YF,Zhu YN,Ni J,Zhong XG,Tang W,Zhou R,Zhou Y,Dong JR,He PL,Wan H,Li YC,Yang YF,Zuo JP

更新日期：2006-06-01 00:00:00

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00