Wallerian degeneration induces Ia-antigen expression in the rat brain.

abstract：:We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barkhof criteria at baseline. 60.0% of CIS patients with p...

journal_title：Journal of neuroimmunology

authors： Kinoshita M,Daifu M,Tanaka K,Tanaka M

更新日期：2017-06-15 00:00:00

abstract：:Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronc...

journal_title：Journal of neuroimmunology

authors： Caulfield JI,Schopf KJ,Cavigelli SA

更新日期：2020-11-25 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00

abstract：:To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myeli...

journal_title：Journal of neuroimmunology

authors： Stinissen P,Zhang J,Vandevyver C,Hermans G,Raus J

更新日期：1998-07-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of adenos...

journal_title：Journal of neuroimmunology

authors： Ahmad S,Elsherbiny NM,Bhatia K,Elsherbini AM,Fulzele S,Liou GI

更新日期：2014-12-15 00:00:00

abstract：:In this report, we show that the human astroglioma cell line, D54-MG, constitutively expresses C3 mRNA and secretes antigenically detectable C3 protein. The cytokine interferon-gamma (IFN-gamma) enhances C3 mRNA and protein expression by D54-MG cells in a dose- and time-dependent manner. C3 mRNA from both D54-MG cells...

journal_title：Journal of neuroimmunology

authors： Barnum SR,Jones JL,Benveniste EN

更新日期：1992-06-01 00:00:00

abstract：:To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

journal_title：Journal of neuroimmunology

authors： Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

更新日期：2000-04-03 00:00:00

abstract：:We investigated the role of IFN-gamma activated microglia in the passage of T lymphocytes across a monolayer of brain endothelial cells (EC) in vitro. Microglia isolated from Fisher 344 (F344) newborn rats were stimulated with IFN-gamma (100 U/ml) for 48 h. T lymphocytes primed with glioma cells were 51Cr-labeled, and...

journal_title：Journal of neuroimmunology

authors： Watanabe T,Tanaka R,Taniguchi Y,Yamamoto K,Ono K,Yoshida S

更新日期：1998-01-01 00:00:00

abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

journal_title：Journal of neuroimmunology

authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

更新日期：2001-06-01 00:00:00

abstract：:Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...

journal_title：Journal of neuroimmunology

authors： Ghosh R,Dubey S,Ray BK,Purkait S,Pandit A,Benito-León J

更新日期：2020-11-15 00:00:00

abstract：:To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

journal_title：Journal of neuroimmunology

authors： Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

更新日期：2011-09-15 00:00:00

abstract：:Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr...

journal_title：Journal of neuroimmunology

authors： Roy S,Charboneau RG,Barke RA

更新日期：1999-03-01 00:00:00

abstract：:In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple sclerosis (MS) appears to be influenced by other loci. A recent study has identified a population association with an immunoglobulin heavy chain variable region polymorphism in the VH2-B5 family, with both familial and sporad...

journal_title：Journal of neuroimmunology

authors： Hashimoto LL,Walter MA,Cox DW,Ebers GC

更新日期：1993-04-01 00:00:00

abstract：:In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incid...

journal_title：Journal of neuroimmunology

authors： Yin L,Chen Y,Qu Z,Zhang L,Wang Q,Zhang Q,Li L

更新日期：2014-09-15 00:00:00

abstract：:A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

journal_title：Journal of neuroimmunology

authors： Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

更新日期：2006-08-01 00:00:00

abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

journal_title：Journal of neuroimmunology

authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

更新日期：2017-09-15 00:00:00

abstract：:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology and pathogenesis of MS and NMOSD remain unclear. The pathogenesis of these two diseases involves a genetic predisposition as well as environmental factors. NMOSD som...

journal_title：Journal of neuroimmunology

authors： Liang H,Gao W,Liu X,Liu J,Mao X,Yang M,Long X,Zhou Y,Zhang Q,Zhu J,Wang S,Jin T

更新日期：2019-12-15 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cell...

journal_title：Journal of neuroimmunology

authors： Tavakolpour V,Shokri G,Naser Moghadasi A,Mozafari Nahavandi P,Hashemi M,Kouhkan F

更新日期：2018-12-15 00:00:00

abstract：:Demyelination, a pathological hallmark of multiple sclerosis, may be a necessary but not a sufficient condition for motor dysfunction associated with this disease. We favor a neurodegenerative model of multiple sclerosis and suggest that demyelination creates a permissive environment wherein the denuded axon becomes s...

journal_title：Journal of neuroimmunology

authors： Howe CL,Ure D,Adelson JD,LaFrance-Corey R,Johnson A,Rodriguez M

更新日期：2007-08-01 00:00:00

abstract：:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren'...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

更新日期：2020-06-15 00:00:00

abstract：:HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in microglia with different phenotypes, ranging from ramified to amoebo...

journal_title：Journal of neuroimmunology

authors： Hendrickx DAE,van Eden CG,Schuurman KG,Hamann J,Huitinga I

更新日期：2017-08-15 00:00:00

abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

journal_title：Journal of neuroimmunology

authors： Tajti J,Stefani E,Appel SH

更新日期：1991-11-01 00:00:00

abstract：:Previously, our laboratory showed that either abrupt (AW) or precipitated withdrawal (PW) from morphine led to profound suppression of murine splenic antibody responses to sheep red blood cells at 24 h post-withdrawal. In the present studies, we examined the immune mechanisms mediating suppression at that time point. ...

journal_title：Journal of neuroimmunology

authors： Rahim RT,Feng P,Meissler JJ,Rogers TJ,Zhang L,Adler MW,Eisenstein TK

更新日期：2004-02-01 00:00:00

abstract：:Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence th...

journal_title：Journal of neuroimmunology

authors： Guyon A,Massa F,Rovère C,Nahon JL

更新日期：2008-07-31 00:00:00

abstract：:This report is to alert other investigators that Lewis rats, which are widely employed in studies of autoimmune diseases, vary considerably with respect to susceptibility to experimental autoimmune encephalomyelitis (EAE), depending upon commercial source. ...

journal_title：Journal of neuroimmunology

authors： Gould KE,Stepaniak JA,Swanborg RH

更新日期：1994-10-01 00:00:00

abstract：:Axonal injury is the major cause of disability in patients with multiple sclerosis (MS), but the mechanisms leading to axonal damage are poorly understood. Oligoclonal IgM against lipids predicts an aggressive disease course in MS; however, the antigen that elicits the immune response has not yet been identified. We s...

journal_title：Journal of neuroimmunology

authors： Beltrán E,Hernández A,Lafuente EM,Coret F,Simó-Castelló M,Boscá I,Pérez-Miralles FC,Burgal M,Casanova B

更新日期：2012-06-15 00:00:00

abstract：:Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors an...

journal_title：Journal of neuroimmunology

authors： Kawano M,Takagi R,Kaneko A,Matsushita S

更新日期：2015-12-15 00:00:00

abstract：:The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype. In this study we analyzed th...

journal_title：Journal of neuroimmunology

authors： Costa P,Castoldi AF,Traver DJ,Costa LG

更新日期：1994-01-01 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00