当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis.

A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis.

Abstract：

:Aberrant activation of calpain plays a key role in the pathophysiology of several neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in EAE and is significantly elevated in the white matter of patients with multiple sclerosis, thus calpain inhibition could be a target for therapeutic intervention. The experiments reported here employed a myelin oligodendrocyte glycoprotein-induced disease model in C57Bl/6 mice (EAE) and a novel calpain inhibitor, targeted to nervous tissue. CYLA was found to reduce clinical signs of EAE and prevent demyelination and inflammatory infiltration in a dose- and time-dependent manner. Oral administration of the diacetal prodrug was equally effective.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hassen GW,Feliberti J,Kesner L,Stracher A,Mokhtarian F

doi

10.1016/j.jneuroim.2006.08.005

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

135-46

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00316-X

journal_volume

180

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Enhancement of antigen-specific T-cell reactivity on the affected side in stroke patients.

    abstract：:We have analyzed the impact of stroke with subsequent hemiparesis and sensory loss on in vivo mediated immune functions. The delayed-type hypersensitivity (DTH) reaction to purified protein derivate (PPD, tuberculin) was used as a measure of antigen-specific T-cell reactivity, and subcutaneous immunization with influe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90099-s

    authors： Tarkowski E,Ekelund P,Tarkowski A

    更新日期：1991-10-01 00:00:00

  • Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.

    abstract：:We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, mac...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.10.001

    authors： Akaishi T,Kaneko K,Himori N,Takeshita T,Takahashi T,Nakazawa T,Aoki M,Nakashima I

    更新日期：2017-12-15 00:00:00

  • Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease.

    abstract：:Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patien...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.06.004

    authors： Strunk D,Schulte-Mecklenbeck A,Golombeck KS,Meyer Zu Hörste G,Melzer N,Beuker C,Schmidt A,Wiendl H,Meuth SG,Gross CC,Minnerup J

    更新日期：2018-08-15 00:00:00

  • Decreased expression of HLA-DR antigens on monocytes in patients with multiple sclerosis.

    abstract：:Immunofluorescence, cell binding assays and enzyme immunoassays were used to investigate the expression of class II major histocompatibility antigens on peripheral blood monocytes in 67 patients with multiple sclerosis. Monocytes from patients with active disease expressed fewer HLA-DR molecules on their surface than ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90015-5

    authors： Baxevanis CN,Reclos GJ,Arsenis P,Anastasopoulos E,Katsiyiannis A,Lymberi P,Matikas N,Papamichail M

    更新日期：1989-05-01 00:00:00

  • Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R.

    abstract：:Substance P (SP) can produce cytokine-like responses by astrocytes and mononuclear cells. In an effort to identify neurokinin-1-receptors (NK1-R), an antibody to NK1-R was generated by using a linear peptide sequence from the deduced third extracellular region (ECR) corresponding to the seven transmembrane rat brain N...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00033-1

    authors： van Ginkel FW,Pascual DW

    更新日期：1996-06-01 00:00:00

  • Elevation of serum prostaglandin E levels following electrical stimulation of the midbrain.

    abstract：:Serum prostaglandin E (PGE) levels were measured in rats immediately following electrical stimulation of the mesencephalic periaqueductal gray (PAG) region and the nucleus raphe magnus (NRM) and compared to controls. An additional group received aspirin prior to PAG stimulation. A significant increase in serum PGE lev...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(82)90024-8

    authors： Rosshirt W,Simon RH,Shaskan EG,Siok C,Dore-Duffy P

    更新日期：1982-11-01 00:00:00

  • Impairment of electrophysiological function of astrocytes by cerebrospinal fluid from a patient with Waldenström's macroglobulinemia.

    abstract：:Patients with the Bing Neel type of Waldenström's macroglobulinemia often present with global neurological symptoms. In this case report, we investigated the effects of cerebrospinal fluid (CSF) of a such a patients (CSF-WM), who presented with seizures and psychomotor slowing, on the electrophysiological properties o...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00069-e

    authors： Köller H,von Giesen HJ,Siebler M

    更新日期：1995-08-01 00:00:00

  • Antibodies to interleukin-1 inhibit cytokine-induced proliferation of neonatal rat Schwann cells in vitro.

    abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90018-3

    authors： Lisak RP,Bealmear B

    更新日期：1991-02-01 00:00:00

  • Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitisation.

    abstract：:15% of myasthenia gravis (MG) patients do not have antibodies against the acetylcholine receptor (AChR). Some of these "seronegative" MG patients have antibodies against muscle specific kinase (MuSK), and many have a non-IgG factor that acutely inhibits AChR function in a muscle-like cell line, CN21. Here we show, usi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.01.009

    authors： Spreadbury I,Kishore U,Beeson D,Vincent A

    更新日期：2005-05-01 00:00:00

  • Role of genetic background in P selectin-dependent immune surveillance of the central nervous system.

    abstract：:Although the blood-brain barrier and blood cerebrospinal fluid barrier maintain the central nervous system (CNS) as an immunologically privileged site, T lymphocytes can migrate through unstimulated brain endothelium and epithelium to perform immune surveillance or initiate inflammation. Our prior results suggested th...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00172-8

    authors： Carrithers MD,Visintin I,Viret C,Janeway CS Jr

    更新日期：2002-08-01 00:00:00

  • Determination of interferon-gamma in the peripheral blood of multiple sclerosis patients in remission, using a chemiluminescence technique.

    abstract：:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. It...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(86)90046-9

    authors： Hammann KP,Hopf HC

    更新日期：1986-11-01 00:00:00

  • Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

    abstract：:Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha1beta1+PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, th...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.04.013

    authors： Sinha S,Miller L,Subramanian S,McCarty OJ,Proctor T,Meza-Romero R,Huan J,Burrows GG,Vandenbark AA,Offner H

    更新日期：2010-08-25 00:00:00

  • Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.

    abstract：:The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.09.023

    authors： Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

    更新日期：2007-12-01 00:00:00

  • A chemiluminescence assay to detect antibodies to brain surface antigens in human sera.

    abstract：:A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90199-6

    authors： Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

    更新日期：1994-01-01 00:00:00

  • Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes.

    abstract：:The effect of interleukin-17 (IL-17) on production of nitric oxide (NO) in rodent astrocytes was investigated. While IL-17 by itself did not induce NO production, it caused a dose-dependent enhancement of IFN-gamma-triggered NO synthesis in both mouse and rat primary astrocytes. In contrast, IL-17 was unable to stimul...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00391-5

    authors： Trajkovic V,Stosic-Grujicic S,Samardzic T,Markovic M,Miljkovic D,Ramic Z,Mostarica Stojkovic M

    更新日期：2001-10-01 00:00:00

  • Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes.

    abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.012

    authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

    更新日期：2005-10-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis.

    abstract：:Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the enceph...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2018.07.002

    authors： Kostic M,Zivkovic N,Cvetanovic A,Stojanovic I

    更新日期：2018-10-15 00:00:00

  • Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset.

    abstract：:Influenza virus invades the olfactory bulb (OB) and enhances cytokine mRNAs therein at the time of illness onset. Here we show that viral antigen immunoreactivity co-localized with glial markers in the OB but could not be detected in other brain areas. Interleukin 1beta- and tumor necrosis factor alpha-immunoreactivit...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.03.016

    authors： Leyva-Grado VH,Churchill L,Wu M,Williams TJ,Taishi P,Majde JA,Krueger JM

    更新日期：2009-06-25 00:00:00

  • Lymphocyte subsets and CD45RA positive T-cells in normal canine cerebrospinal fluid.

    abstract：:In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/S0165-5728(97)00192-6

    authors： Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

    更新日期：1998-02-01 00:00:00

  • Antiphospholipid syndrome presenting as treatment resistant bipolar disorder and thrombocytopenia in a young male.

    abstract：:Antiphospholipid syndrome (APS), an autoantibody mediated disease, is characterized by presence of antibodies against the proteins bound to the phospholipid membranes. The antibodies are predominantly formed against beta-2-glycoprotein I (b2GPI) which is considered pathogenic, but presence of lupus anticoagulant is a ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577238

    authors： Aneja J,Kuppili PP,Paul K,Panda S,Purohit A

    更新日期：2020-06-15 00:00:00

  • Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice.

    abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.04.006

    authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

    更新日期：2005-07-01 00:00:00

  • Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease.

    abstract：:The urokinase plasminogen activator (uPA) and its receptor (uPAR) play important physiological functions in extracellular proteolysis, as well as cell adhesion and migration. Through dysregulation of these functions, the uPA/uPAR system might be involved in the pathogenesis of AIDS dementia complex (ADC), and, in fact...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.08.038

    authors： Sidenius N,Nebuloni M,Sala S,Zerbi P,Price RW,Gisslen M,Hagberg L,Vago L,Lazzarin A,Blasi F,Cinque P

    更新日期：2004-12-01 00:00:00

  • Increased plasma levels of high mobility group box 1 protein in patients with bipolar disorder: A pilot study.

    abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.576993

    authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

    更新日期：2019-09-15 00:00:00

  • Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain.

    abstract：:Opioid-containing immunocytes migrate to inflamed sites where they release beta-endorphin which activates peripheral opioid receptors and produces analgesia. The immigration of immunocytes to sites of inflammation is mediated by adhesion molecules. In this study, the expression of L-, P-, E-selectin and platelet-endot...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00284-8

    authors： Mousa SA,Machelska H,Schäfer M,Stein C

    更新日期：2000-08-01 00:00:00

  • Dendritic cells in experimental allergic encephalomyelitis and multiple sclerosis.

    abstract：:The mechanisms by which autoimmune diseases are triggered and by which the activation of autoreactive T cells is initiated and maintained are not yet fully understood. As the most potent antigen presenting cells (APC), and also being responsible for antigen transport as well as primary sensitisation of T cells, dendri...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-5728(99)00197-6

    authors： Link H,Huang YM,Xiao BG

    更新日期：1999-12-01 00:00:00

  • Preferential association of V lambda x light chains with gamma 2a heavy chains in naturally occurring human myelin basic protein reactive antibodies.

    abstract：:Active immunization with myelin basic protein (MBP) induces experimental allergic encephalomyelitis (EAE) in a variety of animal species, including rats and mice. We have previously described the ability of the newly described mouse lambda (lambda) variable (V) region V lambda x, to confer MBP reactivity to an Ab. In ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00072-0

    authors： Galin FS,Zhou SR,Whitaker JN,Blalock JE

    更新日期：1996-10-01 00:00:00

  • Differential immune responses in mice with left- and right-turning preference.

    abstract：:Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00222-7

    authors： Kim D,Carlson JN,Seegal RF,Lawrence DA

    更新日期：1999-01-01 00:00:00

  • MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).

    abstract：:Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevate...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.06.008

    authors： Zhang R,Gascon R,Miller RG,Gelinas DF,Mass J,Lancero M,Narvaez A,McGrath MS

    更新日期：2006-10-01 00:00:00

  • Role of IL-5 during primary and secondary immune response to acetylcholine receptor.

    abstract：:To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00030-9

    authors： Poussin MA,Goluszko E,Franco JU,Christadoss P

    更新日期：2002-04-01 00:00:00

  • Human myelin basic protein specific T cell lines display differential cytotoxicity against astrocytes, but are consistently cytotoxic against monocytes.

    abstract：:In experimental allergic encephalomyelitis (EAE) myelin basic protein (MBP) specific T cells differ in their encephalitogenic potential. To investigate the functional diversity of human MBP specific T cell lines, we analysed their cytotoxic activity against human astrocytes and monocytes. Five out of 14 MBP specific T...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00093-9

    authors： Weber F,Huber S,Aloisi F,Meinl E

    更新日期：1998-08-01 00:00:00