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Role of genetic background in P selectin-dependent immune surveillance of the central nervous system.

Abstract：

:Although the blood-brain barrier and blood cerebrospinal fluid barrier maintain the central nervous system (CNS) as an immunologically privileged site, T lymphocytes can migrate through unstimulated brain endothelium and epithelium to perform immune surveillance or initiate inflammation. Our prior results suggested that early CNS migration of a CD4 Th1 cell line was facilitated by P selectin (CD62P) in (PL/JxSJL/J)F1 mice. Here, quantitative analysis of migration 2 h following adoptive transfer of fluorescently labeled cells revealed a 53-72% decrease in activated splenocyte, CD4 Th1 and CD8 migration, but not CD4 Th2, in CD62P-deficient C57BL6/J mice. Immunohistochemistry revealed constitutive expression of CD62P within the meninges and choroid plexus epithelia in C57BL6/J and SJL/J, but not BALB/cJ, mice. Activated splenocyte migration was approximately three- to four-fold greater in SJL/J as compared to BALB/cJ mice. Anti-CD62P treatment normalized this difference. Based on these results, we hypothesize that genetically determined kinetics of immune surveillance may regulate the phenotype of subsequent CNS inflammation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Carrithers MD,Visintin I,Viret C,Janeway CS Jr

doi

10.1016/s0165-5728(02)00172-8

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

51-7

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802001728

journal_volume

129

pub_type

杂志文章

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