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Optic nerve involvement in experimental autoimmune encephalomyelitis to homologous spinal cord homogenate immunization in the dark agouti rat.

Abstract：

:Dark-Agouti rats were immunized with spinal cord homogenate to develop Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis. We assessed motor signs and recorded VEPs for five or eight weeks with epidural or epidermal electrodes, respectively, with final histopathology of optic nerves (ONs). Injected rats exhibited motor deficits a week after immunization. VEP delays arose from the 2nd to the 5th week, when a recovery occurred in epidermal-recorded rats. ON damage appeared in epidural-, but not in epidermal-recorded rats, probably due to a remyelination process. VEP could be exploited as neurophysiological marker to test novel treatments against neurodegeneration involving ONs.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Castoldi V,Marenna S,Santangelo R,d'Isa R,Cursi M,Chaabane L,Quattrini A,Comi G,Leocani L

doi

10.1016/j.jneuroim.2018.09.009

subject

Has Abstract

pub_date

2018-12-15 00:00:00

pages

1-9

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30375-8

journal_volume

325

pub_type

杂志文章

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