Abstract:
:The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methylation of the SHP-1 promoter is responsible for aberrant silencing of SHP-1 expression and function in hematopoietic cells that might relate to inflammatory diseases. In the present study, bisulfite sequencing of the SHP-1 promoter demonstrated that over a third of MS subjects had abnormally high promoter methylation. As SHP-1 is deficient in MS leukocytes and SHP-1-regulated proinflammatory genes are correspondingly upregulated, we propose that increased SHP-1 promoter methylation may relate in part to decreased SHP-1 expression and increased leukocyte-mediated inflammation in MS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Kumagai C,Kalman B,Middleton FA,Vyshkina T,Massa PTdoi
10.1016/j.jneuroim.2012.03.003subject
Has Abstractpub_date
2012-05-15 00:00:00pages
51-7issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(12)00067-7journal_volume
246pub_type
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