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The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

Abstract：

:Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene that influences susceptibility and, more specifically, the clinical course of multiple sclerosis. In order to test this hypothesis we genotyped the polymorphism in 951 UK multiple sclerosis trio families, but found no evidence for association before (p=0.63) or after stratification for clinical course (p=0.73).

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

doi

10.1016/j.jneuroim.2005.06.008

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

183-5

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00232-8

journal_volume

167

pub_type

杂志文章

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