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Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.

Abstract：

:Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expressed in the MG muscle membrane, with partial loss of expression and overexpression in 5/15 and 10/15 patients, respectively. Caveolin-3 mRNA and protein levels were higher in MG than in control muscles, suggesting that partial deficiency of caveolin-3 is occasionally detected in MG muscle and that caveolin-3 overexpression may be required after MG muscle damage.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Iwasa K,Furukawa Y,Yoshikawa H,Yamada M

doi

10.1016/j.jneuroim.2016.10.011

subject

Has Abstract

pub_date

2016-12-15 00:00:00

pages

30-34

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30378-2

journal_volume

301

pub_type

杂志文章

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