Abstract：
:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cells of this strain. Second, it was asked whether MBP peptides other than 89-101 would induce EAE in these mice. Of 70 B10.RIII(71NS)/SnJ mice immunized with mouse myelin basic protein (MBP), 32 of 41 males (78%) and 11 of 29 females (38%) showed clinical signs of experimental allergic encephalomyelitis (EAE). All mice immunized with peptide 89-101 showed clinical signs. One of six mice immunized with peptide 91-103 showed clinical signs, and 9 of 16 mice, all males, responded with EAE when immunized with peptide 38-88. No clinical EAE was observed in mice immunized with peptide 43-67, 68-88, 55-74, 1-37 or 1-20. A peptide 89-101-specific T cell line was established. At the initial stimulation the line was 29% V beta 8+ versus 21% in normal controls, and the line did not transfer EAE adoptively. After five in vitro stimulations, the percentage of V beta 8+ T cells had increased to 54%, and the line was encephalitogenic. Encephalitogenicity was partially blocked by anti-V beta 8 monoclonal antibody. Thus, over-representation of V beta 8+ TCR by encephalitogenic peptide-specific T cells is not limited to peptide 1-11-specific T cells from H-2u mice.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Zhao ML,Xia JQ,Fritz RBdoi
10.1016/0165-5728(93)90012-nsubject
Has Abstractpub_date
1993-02-01 00:00:00pages
209-14issue
2eissn
0165-5728issn
1872-8421pii
0165-5728(93)90012-Njournal_volume
42pub_type
杂志文章abstract：:We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey ...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2017-05-15 00:00:00
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更新日期：2006-07-01 00:00:00
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更新日期：2013-03-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(95)00022-t
更新日期：1995-05-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：1987-02-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(98)00153-2
更新日期：1998-11-02 00:00:00
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更新日期：2014-08-15 00:00:00
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pub_type： 杂志文章
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更新日期：2017-10-15 00:00:00
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pub_type： 杂志文章
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更新日期：2012-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0165-5728(03)00088-2
更新日期：2003-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-5728(89)90075-1
更新日期：1989-06-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2009.05.010
更新日期：2009-08-18 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 临床试验,杂志文章
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更新日期：1990-06-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2018.07.004
更新日期：2018-10-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-5728(98)00266-5
更新日期：1999-03-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(89)90083-0
更新日期：1989-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(91)90040-e
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pub_type： 杂志文章
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更新日期：1992-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2006.02.015
更新日期：2006-06-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2014.12.009
更新日期：2015-01-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2007-04-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2016.10.013
更新日期：2016-12-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(00)00348-9
更新日期：2000-10-02 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
doi：10.1016/s0165-5728(99)00213-1
更新日期：1999-12-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(95)00076-e
更新日期：1995-09-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2008.11.003
更新日期：2009-01-03 00:00:00
