MicroRNAs associated with the pathogenesis of multiple sclerosis.

abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-α is involved in the pathogenesis of multiple scle...

journal_title：Journal of neuroimmunology

authors： Caminero A,Comabella M,Montalban X

更新日期：2011-05-01 00:00:00

abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

journal_title：Journal of neuroimmunology

authors： Tsunoda I,Libbey JE,Fujinami RS

更新日期：2007-08-01 00:00:00

abstract：:Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1:200 or less, six patients had titers of 1:800 or more. Some GBS patients with anti...

journal_title：Journal of neuroimmunology

authors： Ilyas AA,Mithen FA,Chen ZW,Cook SD

更新日期：1992-01-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

journal_title：Journal of neuroimmunology

authors： Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

更新日期：2010-12-15 00:00:00

abstract：:Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP reporter mice. Effecto...

journal_title：Journal of neuroimmunology

authors： Kulcsar KA,Griffin DE

更新日期：2016-06-15 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00

abstract：:Serum levels of immunoreactive interleukin-2 (IL-2) were determined at monthly intervals from a group of placebo- and drug-treated chronic progressive multiple sclerosis patients before and during a cyclosporine A therapeutic trial. Significantly elevated levels of the lymphokine in active patients confirmed earlier s...

journal_title：Journal of neuroimmunology

authors： Trotter JL,van der Veen RC,Clifford DB

更新日期：1990-06-01 00:00:00

abstract：:We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negativ...

journal_title：Journal of neuroimmunology

authors： Kadoya M,Kaida K,Koike H,Takazaki H,Ogata H,Moriguchi K,Shimizu J,Nagata E,Takizawa S,Chiba A,Yamasaki R,Kira JI,Sobue G,Ikewaki K

更新日期：2016-12-15 00:00:00

abstract：:Autism spectrum disorders are a heterogeneous group of behaviorally defined disorders having complex etiologies. We previously reported a direct correlation between lower plasma levels of the immunoglobulins (Ig) IgG and IgM and increased severity of behavioral symptoms in children with autism. Our current objective w...

journal_title：Journal of neuroimmunology

authors： Heuer LS,Rose M,Ashwood P,Van de Water J

更新日期：2012-10-15 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue an...

journal_title：Journal of neuroimmunology

authors： Wang YJ,Wang X,Zhang H,Zhou L,Liu S,Kolson DL,Song L,Ye L,Ho WZ

更新日期：2009-01-03 00:00:00

abstract：:We reviewed the records of 391 patients who had presented with a Clinically Isolated Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We studied cerebrospinal fluid (CSF) and serum IgM oligoclonal bands (IgMOB) using agarose gel isoelectric focusing and analyzed the impact of baseline cl...

journal_title：Journal of neuroimmunology

authors： Ferraro D,Simone AM,Bedin R,Galli V,Vitetta F,Federzoni L,D'Amico R,Merelli E,Nichelli PF,Sola P

更新日期：2013-04-15 00:00:00

abstract：:SJL/J mice were infected with a recombinant vaccinia virus encoding myelin proteolipid protein (PLP) (VVplp). Antibody responses to whole PLP and to encephalitogenic peptides, p139-151, p178-191 or p104-117 were measured after vaccination and following challenge with these three PLP peptides. Competitive ELISAs showed...

journal_title：Journal of neuroimmunology

authors： Wang LY,Fujinami RS

更新日期：1997-05-01 00:00:00

abstract：:To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with hyaluronidase. Induction of meningitis resulted in an upregulation of both pro- and matur...

journal_title：Journal of neuroimmunology

authors： Zwijnenburg PJ,van der Poll T,Florquin S,Akira S,Takeda K,Roord JJ,van Furth AM

更新日期：2003-05-01 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:The pro-inflammatory cytokine IL-1β is known to play a role in several models of aging, neuroinflammation, and neurodegenerative diseases. Here, we document a detailed time- and age-dependent pattern of pro- and anti-inflammatory biomarkers following bilateral intrahippocampal injection of interleukin-1β. During the f...

journal_title：Journal of neuroimmunology

authors： Hopp SC,Royer S,Brothers HM,Kaercher RM,D'Angelo H,Bardou I,Wenk GL

更新日期：2014-02-15 00:00:00

abstract：:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

journal_title：Journal of neuroimmunology

authors： Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

更新日期：2000-01-03 00:00:00

abstract：:Gangliosides modulate various T cell effector functions through poorly defined mechanisms. To begin to understand one of their effects, the present study examined how normal brain-derived gangliosides suppress T cell proliferation using the murine T cell line, EL4, as a model. Gangliosides inhibited EL4 cell growth by...

journal_title：Journal of neuroimmunology

authors： Irani DN

更新日期：1998-07-01 00:00:00

abstract：:The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, a...

journal_title：Journal of neuroimmunology

authors： Bernardes D,Oliveira-Lima OC,Silva TV,Faraco CC,Leite HR,Juliano MA,Santos DM,Bethea JR,Brambilla R,Orian JM,Arantes RM,Carvalho-Tavares J

更新日期：2013-11-15 00:00:00

abstract：:Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR α1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 ...

journal_title：Journal of neuroimmunology

authors： Uzawa A,Ozawa Y,Yasuda M,Oda F,Kojima Y,Kawaguchi N,Kanai T,Himuro K,Kuwabara S

更新日期：2020-02-15 00:00:00

abstract：:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

journal_title：Journal of neuroimmunology

authors： Argall KG,Armati PJ,Pollard JD,Bonner J

更新日期：1992-09-01 00:00:00

abstract：:Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors an...

journal_title：Journal of neuroimmunology

authors： Kawano M,Takagi R,Kaneko A,Matsushita S

更新日期：2015-12-15 00:00:00

abstract：:Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3...

journal_title：Journal of neuroimmunology

authors： Kyrkanides S,O'Banion MK,Whiteley PE,Daeschner JC,Olschowka JA

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese. METHODS:205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for h...

journal_title：Journal of neuroimmunology

authors： Zhu WH,Lu JH,Lin J,Xi JY,Lu J,Luo SS,Qiao K,Xiao BG,Lu CZ,Zhao CB

更新日期：2012-06-15 00:00:00

abstract：:Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human pe...

journal_title：Journal of neuroimmunology

authors： Shibata A,Zelivyanskaya M,Limoges J,Carlson KA,Gorantla S,Branecki C,Bishu S,Xiong H,Gendelman HE

更新日期：2003-09-01 00:00:00

abstract：:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...

journal_title：Journal of neuroimmunology

authors： Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

更新日期：2011-07-01 00:00:00

abstract：:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

journal_title：Journal of neuroimmunology

authors： Hohlfeld R,Toyka KV

更新日期：1985-08-01 00:00:00

abstract：:The central nervous system plays an active role in the regulation of the immune system. Modulation of immune activities appears to be in part under the control of the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the effect of a muscarinic cholinergic agonist, arecoline, which stimulates the secretion of ...

journal_title：Journal of neuroimmunology

authors： Demissie S,Rogers CF,Hiramoto NS,Ghanta VK,Hiramoto RN

更新日期：1995-06-01 00:00:00

abstract：:We studied the effect of interferons on the expression of class II histocompatibility (HLA-DR) antigens by cultured adult human astrocytes. Cultures were derived from brain tissue resected for surgical treatment of intractable epilepsy. Cultured astrocytes did not spontaneously display HLA-DR antigen as determined by ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Yen-Lieberman B,Ransohoff RM

更新日期：1989-06-01 00:00:00

abstract：:Patients with progressive multiple sclerosis (MS) and controls were compared with regard to: (a) in vitro pokeweed mitogen (pwm)-induced IgG secretion, as an indirect measure of T8+ cell-mediated suppressor function; (b) alloantigen-directed cytotoxic activity, a predominantly T8+ cell-mediated function. The MS group ...

journal_title：Journal of neuroimmunology

authors： Antel JP,Nicholas MK,Bania MB,Reder AT,Arnason BG,Joseph L

更新日期：1986-09-01 00:00:00

abstract：:Rat thymocytes incubated in RPMI medium for 120-300 min release a soluble factor of molecular weight below 10,000 Da which inhibits the binding of 3H-labeled muscarinic antagonists in an uncompetitive manner, i.e. it reduces maximal specific binding (Bmax) without changing the affinity of the ligand (KD). This factor ...

journal_title：Journal of neuroimmunology

authors： Maslinski W,Ryzewski J,Bartfai T

更新日期：1988-03-01 00:00:00