Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes.

Abstract:

:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antigens. Autoreactive helper T cell lines may become useful tools for the evaluation of new immunotherapeutic strategies. (1) Treatment with anti-Ia monoclonal antibodies presumably interferes with the interaction between Ia on the surface of antigen-presenting cells and the autoreactive T cell receptor; (2) Therapy with unmodified or modified autoantigen may be used to tolerize or delete the autoimmune T cells; (3) Monoclonal antibodies against the 'T cell domains' of autoantigen may prevent its recognition by the autoreactive T cells; (4) Treatment with monoclonal antibodies against T cell clonotypic or differentiation antigens may effectively delete or inactivate the autoreactive T cells. Furthermore, autoreactive helper T cells may be used to induce and establish anti-idiotypic suppressor T cell lines, or the autoimmune helper T cells may themselves display suppressive effects in an allogeneic system.

journal_name

J Neuroimmunol

authors

Hohlfeld R,Toyka KV

doi

10.1016/s0165-5728(85)80018-7

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

193-204

issue

3-4

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(85)80018-7

journal_volume

9

pub_type

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