当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments.

Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments.

Abstract：

:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, IgM and IgA immunoglobulin isotypes in 28 relapsing remitting MS patients and report that linear epitopes amino-acid (aa) 37-48 and aa42-53 are immunodominant. Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

doi

10.1016/j.jneuroim.2006.01.012

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

147-56

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00014-2

journal_volume

174

pub_type

临床试验,杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease.

    abstract：:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2011.02.007

    authors： Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

    更新日期：2011-06-01 00:00:00

  • Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions.

    abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00036-5

    authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

    更新日期：2003-05-01 00:00:00

  • DNA repair, sensitivity to gamma radiation and to heat shock in lymphocytes from acute, untreated multiple sclerosis patients.

    abstract：:Increases in spontaneous sister chromatid exchange (SCE) and gamma radiation-induced chromosome aberrations have been reported in peripheral blood lymphocytes (PBL) from multiple sclerosis (MS) patients, suggesting the presence of an abnormality in repair in this disease. We tested this hypothesis by measuring the abi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90155-0

    authors： Sola P,Merelli E,Faglioni P,Monti D,Cossarizza A,Franceschi C

    更新日期：1989-01-01 00:00:00

  • Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis.

    abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.10.004

    authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

    更新日期：2013-12-15 00:00:00

  • Low-dosage of rituximab in Chinese patients with neuromyelitis optica spectrum disorder.

    abstract：:Rituximab has been effectively used for treating neuromyelitis optica spectrum disorder (NMOSD) for several years. However those regimens exert a heavy burden on Chinese patients. The aim of our study was to investigate an effectiveness, economic alternatives of RTX. The enrolled patients received different immunosupp...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jneuroim.2018.02.004

    authors： Lin J,Li X,Xue B,Tong Q,Chen Z,Zhu W,Li J,Xia J

    更新日期：2018-04-15 00:00:00

  • The importance of clinical trials in unraveling the mysteries of multiple sclerosis.

    abstract：:Despite a number of new therapies that are effective in reducing the inflammatory component of multiple sclerosis, the underlying cause of the disease remains uncertain. One of the most powerful tools available to an investigator to help in unraveling the underlying disease mechanisms in MS is the incorporation of car...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2010.12.010

    authors： McFarland H

    更新日期：2011-02-01 00:00:00

  • The role of laquinimod in modulation of the immune response in relapsing-remitting multiple sclerosis: Lessons from gene expression signatures.

    abstract：:Laquinimod, is a potential oral immunomodulatory drug, for relapsing-remitting multiple sclerosis (RRMS). We analyzed the blood-transcriptional changes in RRMS patients (who participated in the ALLEGRO clinical trial) at one and six months after laquinimod treatment using gene expression microarrays. The molecular eff...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.04.007

    authors： Zilkha-Falb R,Gurevich M,Hayardeny L,Achiron A

    更新日期：2015-06-15 00:00:00

  • Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-β and interferon-β combined with low-dose oral steroids.

    abstract：:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2011.05.005

    authors： Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

    更新日期：2011-07-01 00:00:00

  • Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.

    abstract：:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which i...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.027

    authors： Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

    更新日期：2005-10-01 00:00:00

  • Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation.

    abstract：:Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.01.011

    authors： Saab CY,Shamaa F,El Sabban ME,Safieh-Garabedian B,Jabbur SJ,Saadé NE

    更新日期：2009-03-31 00:00:00

  • Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.

    abstract：:We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.10.007

    authors： Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

    更新日期：2005-02-01 00:00:00

  • Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.

    abstract：:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal ant...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90093-m

    authors： Korostoff JM,Nakada MT,Markman JF,Gaulton GN

    更新日期：1991-10-01 00:00:00

  • Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy.

    abstract：:Persistent neuroinflammation is implicated in the pathogenesis of seizures and neuronal degeneration of temporal lobe epilepsy (TLE). Circulating level of inflammatory cytokines was determined during inter-ictal period of 25 non-operated and 10 patients (OP) submitted to anterior temporal lobectomy. OP patients showed...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.08.004

    authors： Quirico-Santos T,Meira ID,Gomes AC,Pereira VC,Pinto M,Monteiro M,Souza JM,Alves-Leon SV

    更新日期：2013-01-15 00:00:00

  • Interferon beta in multiple sclerosis: relationship between sustained serum IgG levels and clinical outcome.

    abstract：:We investigated the effects of interferon beta-1a (IFN beta-1a) on specific response towards two immunodominant MBP peptides and on global production of IgG. We evaluated 54 sera from multiple sclerosis (MS) patients at baseline and 1 year after treatment. We did not observe any modification of immune response to the ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-5728(02)00204-7

    authors： Dubucquoi S,de Seze J,Lefranc D,Almeras L,Dutoit V,Prin L,Vermersch P

    更新日期：2002-08-01 00:00:00

  • Soluble Fas (Apo-1) levels in cerebrospinal fluid of multiple sclerosis patients.

    abstract：:CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant co...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/S0165-5728(97)00177-X

    authors： Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi A

    更新日期：1998-02-01 00:00:00

  • Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

    abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.01.001

    authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

    更新日期：2019-02-15 00:00:00

  • T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells.

    abstract：:In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myeli...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00075-1

    authors： Vergelli M,Kalbus M,Rojo SC,Hemmer B,Kalbacher H,Tranquill L,Beck H,McFarland HF,De Mars R,Long EO,Martin R

    更新日期：1997-08-01 00:00:00

  • Failure of alpha-melanocyte stimulating hormone to attenuate cerebral complications in experimental pneumococcal meningitis.

    abstract：:Alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that can inhibit a broad range of inflammatory mediators known to be involved in the pathophysiology of bacterial meningitis. We evaluated the effect of alpha-MSH in a rat model of pneumococcal meningitis. Rats were intraci...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00277-6

    authors： Kastenbauer S,Koedel U,Brzoska T,Luger TA,Pfister HW

    更新日期：2001-05-01 00:00:00

  • Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis.

    abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90131-7

    authors： Stevens DB,Gould KE,Swanborg RH

    更新日期：1994-04-01 00:00:00

  • Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease.

    abstract：:The urokinase plasminogen activator (uPA) and its receptor (uPAR) play important physiological functions in extracellular proteolysis, as well as cell adhesion and migration. Through dysregulation of these functions, the uPA/uPAR system might be involved in the pathogenesis of AIDS dementia complex (ADC), and, in fact...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.08.038

    authors： Sidenius N,Nebuloni M,Sala S,Zerbi P,Price RW,Gisslen M,Hagberg L,Vago L,Lazzarin A,Blasi F,Cinque P

    更新日期：2004-12-01 00:00:00

  • Regional topographical differences of canine microglial immunophenotype and function in the healthy spinal cord.

    abstract：:Differences in the regulation of surface molecule expression and functional activity of microglia, the resident immune effector elements of the central nervous system (CNS), might give important insights into understanding the predilection sites of some diseases within the CNS. Therefore, canine microglial cells in re...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.07.017

    authors： Ensinger EM,Boekhoff TM,Carlson R,Beineke A,Rohn K,Tipold A,Stein VM

    更新日期：2010-10-08 00:00:00

  • 2D immunomic approach for the study of IgG autoantibodies in the experimental model of multiple sclerosis.

    abstract：:2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-im...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.10.004

    authors： Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

    更新日期：2011-03-01 00:00:00

  • Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids.

    abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90079-8

    authors： Paciotti GF,Skwerer RG,Tamarkin L

    更新日期：1987-10-01 00:00:00

  • Suspected bacterial meningomyelitis: The first presenting clinical feature of neuromyelitis optica spectrum disorder.

    abstract：:A rare case of neuromyelitis optica spectrum disorder, suspected to be bacterial meningomyelitis as the initial manifestation, is reported. The patient presented with initial symptoms of meningomyelitis and fever. Cerebrospinal fluid analysis revealed pleocytosis (1280×106/L [98% lymphocytes]) and glucose level of 1.8...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.05.013

    authors： Li X,Lin J,Pan S,Weng Y,Li J,Zhang X,Xia J,Tong Q

    更新日期：2017-08-15 00:00:00

  • Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry.

    abstract：:HIV-induced neurological disease is postulated to be caused by indirect mechanisms. Tumor necrosis factor (TNF)alpha is increased in the brains in human immunodeficiency virus (HIV)-associated dementia and in the spinal cord in vacuolar myelopathy and may play a pathogenetic role in these diseases. Microglia, astrocyt...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00160-9

    authors： Wesselingh SL,Takahashi K,Glass JD,McArthur JC,Griffin JW,Griffin DE

    更新日期：1997-04-01 00:00:00

  • Chronic restraint stress modulates expression of genes in murine spleen.

    abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.05.004

    authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

    更新日期：2006-08-01 00:00:00

  • Behaviorally conditioned immunosuppression using cyclosporine A: central nervous system reduces IL-2 production via splenic innervation.

    abstract：:Bi-directional interactions between the central nervous system (CNS) and immune system are demonstrated by the modification of immune function using behavioral conditioning. However, the mechanisms by which the CNS achieves conditioned immunomodulation are still in question. Here, we report that the immunosuppressive ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00122-2

    authors： Exton MS,von Hörsten S,Schult M,Vöge J,Strubel T,Donath S,Steinmüller C,Seeliger H,Nagel E,Westermann J,Schedlowski M

    更新日期：1998-08-01 00:00:00

  • Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.

    abstract：:Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx int...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00183-1

    authors： Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

    更新日期：2000-06-01 00:00:00

  • Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions.

    abstract：:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00297-1

    authors： De la Fuente M,Del Río M,Medina S

    更新日期：2001-06-01 00:00:00

  • Associations of postpartum sleep, stress, and depressive symptoms with LPS-stimulated cytokine production among African American and White women.

    abstract：BACKGROUND:Postpartum is a period of unique psychosocial stress characterized by sleep disturbance, risk for depressed mood, and heightened parenting stress. However, data on effects of these exposures on inflammatory immune function are limited. METHODS:This study examined associations among sleep, psychosocial stres...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.12.020

    authors： Christian LM,Kowalsky JM,Mitchell AM,Porter K

    更新日期：2018-03-15 00:00:00