Abstract：
:CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant correlation between sFas CSF/sFas serum ratio and BBB damage (expressed as albumin CSF/albumin serum ratio) was detected in non-MS neurological disease, but not in MS patients. The normalized ratio (sFas CSF/sFas serum)/(Alb CSF/Alb serum) was significantly increased in MS patients compared to patients with non-inflammatory neurological disease suggesting an intrathecal synthesis of soluble Fas in MS. The percentage of apoptotic mononuclear cells was higher in CSF as compared to peripheral blood; moreover a lower proportion of apoptotic cells was found in CSF of MS patients. The findings lend support to the involvement of sFas in MS pathogenesis and suggest that a lower apoptosis in CSF may be a feature of the disease.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi Adoi
10.1016/S0165-5728(97)00177-Xsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
5-12issue
1eissn
0165-5728issn
1872-8421pii
S0165-5728(97)00177-Xjournal_volume
82pub_type
杂志文章abstract：:Tumor necrosis factor alpha (TNFalpha) activity was measured in serum and cerebrospinal fluid (CSF) of Lewis rats after experimental allergic encephalomyelitis (EAE) induction and during the clinical course of acute disease. TNFalpha bioactivity expression preceded the clinical symptoms and paralleled the severity of ...
journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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更新日期：2015-09-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2007.07.016
更新日期：2007-10-01 00:00:00
abstract：:Some biochemical events following the binding of prolactin (PRL) to its receptor in normal human leukocytes were investigated. PRL enhanced JAK2 phosphorylation in peripheral blood mononuclear cells (PBMC) but not in granulocytes. PRL also induced phosphorylation of Stat-5 in PBMC and Stat-1 in granulocytes. Subsequen...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(97)00062-3
更新日期：1997-07-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2010.03.020
更新日期：2010-06-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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更新日期：2003-12-01 00:00:00
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journal_title：Journal of neuroimmunology
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
abstract：PURPOSE:It will provide a reference for early detection, early diagnosis and early treatment of atypical primary Sjogren syndrome with neurological impairment as the first symptom. METHODS:Case report and Literature review. RESULTS:Here we report a 30-year-old woman diagnosed with trigeminal damage secondary to pSS w...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
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abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2010.02.014
更新日期：2010-05-01 00:00:00
