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Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes.

Abstract：

:The majority of human oligodendrocytes in enriched glial cell cultures expresses class I major histocompatibility complex (MHC) antigens. We used a 51Cr release assay to study the susceptibility of oligodendrocyte-enriched glial cells to MHC-restricted and non-restricted immune-mediated cytolysis. Mitogen-activated mononuclear cells induced significant lysis in a lectin-dependent cytotoxicity assay. Mononuclear cells allo-activated in a one-way mixed lymphocyte culture with E- cells from the glial cell donor induced a significantly higher degree of oligodendrocyte cytolysis than mononuclear cells activated with E- cells bearing MHC-class I antigens discordant with the glia. Cytolysis by alloactivated unfractionated lymphocytes and by purified CD8+ lymphocytes was reduced by an anti-class I antibody (W6/32). Our findings suggest that human oligodendrocytes can be susceptible targets for MHC class I-restricted lysis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Ruijs TC,Freedman MS,Grenier YG,Olivier A,Antel JP

doi

10.1016/0165-5728(90)90058-u

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

89-97

issue

2-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(90)90058-U

journal_volume

27

pub_type

杂志文章

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