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Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus.

Abstract：

:The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCRalphabeta(low/high) and CD4-CD8+TCRalphabeta(-)thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCRalphabeta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCRalphabeta(+) cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Zivković IP,Rakin AK,Petrović-Djergović DM,Kosec DJ,Mićić MV

doi

10.1016/j.jneuroim.2004.11.002

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

77-86

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(04)00412-6

journal_volume

160

pub_type

杂志文章

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