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Tacrolimus-induced severe headache associated with diffuse leukoencephalopathy: Evidence for an immune-mediated pathogenesis.

Abstract：

:Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrolimus. MRI scan showed diffuse and symmetric alterations involving both supratentorial and infratentorial white matter. Cerebral spinal fluid assessment for infectious diseases were negative but elevated total protein level and oligoclonal bands positivity were reported. Treatment with steroid bolus, along with tacrolimus tapering, provided clinico-radiological improvement. This is the first case of tacrolimus-induced neurotoxicity strongly suggestive of an immune-mediated pathogenesis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Smeralda CL,Gigli GL,Vogrig A,Marini A,Valente M

doi

10.1016/j.jneuroim.2019.01.006

subject

Has Abstract

pub_date

2019-05-15 00:00:00

pages

55-58

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30542-3

journal_volume

330

pub_type

杂志文章

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