Effects on axonal conduction of anti-ganglioside sera and sera from patients with Guillain-Barré syndrome.


:The efficacy of plasma exchange as a therapy for Guillain-Barré syndrome (GBS) suggests that humoral factors might contribute to the axonal conduction block responsible for the major symptoms of the disease. To explore this possibility, we have applied sera to rat spinal roots in vitro while monitoring axonal conduction. Neither fresh sera from 12 patients with GBS or Miller-Fisher syndrome (MFS), nor serum from rabbits immunised with Campylobacter jejuni from patients with GBS, MFS or gastroenteritis were effective in causing acute conduction block, despite the presence of antibodies to gangliosides GD3, GM1, GQ1b and GT1a. Potential explanations are advanced.


J Neuroimmunol


Dilley A,Gregson NA,Hadden RD,Smith KJ




Has Abstract


2003-06-01 00:00:00














  • Immunological consequences of ischemic stroke: immunosuppression and autoimmunity.

    abstract::Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Vogelgesang A,Dressel A

    更新日期:2011-02-01 00:00:00

  • Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: implications for myelination.

    abstract::Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

    更新日期:2006-09-01 00:00:00

  • Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line.

    abstract::We established cultures of human astrocytes and astrocytoma cells from surgical specimens, to study regulation of class II major histocompatibility (MHC) complex antigen expression by interferons. Using these cultures we previously showed that expression of the class II MHC determinant HLA-DR could be induced by inter...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ransohoff RM,Devajyothi C,Estes ML,Babcock G,Rudick RA,Frohman EM,Barna BP

    更新日期:1991-08-01 00:00:00

  • Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo.

    abstract::We investigated the expression and production of the interleukin-1 receptor antagonist (IL-1ra) in three human glioblastoma cell lines (LN443, LN444, LN859). Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of IL-1ra mRNA transcripts in the three cell lines. These three cell lines a...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tada M,Diserens AC,Desbaillets I,Jaufeerally R,Hamou MF,de Tribolet N

    更新日期:1994-03-01 00:00:00

  • Evidence that mouse astrocytes may be derived from the radial glia. An immunohistochemical study of the cerebellum in the normal and reeler mouse.

    abstract::Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

    更新日期:1985-07-01 00:00:00

  • IgG1 deficiency exacerbates experimental autoimmune myasthenia gravis in BALB/c mice.

    abstract::Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to neuromuscular junction (NMJ) damage by anti-acetylcholine receptor (AChR) auto-antibodies and complement. In experimental autoimmune myasthenia gravis (EAMG), which is induced by immunization with Torpedo AChR in CFA, anti-AChR IgG2b an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huda R,Strait RT,Tüzün E,Finkelman FD,Christadoss P

    更新日期:2015-04-15 00:00:00

  • Lymphocyte proliferative response to glial cells in SJL/J mice immunized with rat whole spinal cord and rat myelin basic protein.

    abstract::Lymph node cells (LNC) from SJL/J mice immunized with either rat whole spinal cord (WSC) homogenate or rat myelin basic protein (MBP) in the presence of complete Freund's adjuvant were assayed for their in vitro proliferative response to MBP and whole or sonicated purified oligodendrocytes (OD), and astrocytes. WSC-im...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jewtoukoff V,Bach MA

    更新日期:1989-01-01 00:00:00

  • Multiple sclerosis risk pathways differ in Caucasian and Chinese populations.

    abstract::Large-scale genome-wide association study (GWAS) datasets provide strong support for investigations of the mechanisms underlying multiple sclerosis (MS) by using pathway analysis methods. In our recent study, we conducted a three-stage pathway analysis of GWAS and expression datasets. After identifying 15 shared MS pa...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Liu G,Zhang F,Hu Y,Jiang Y,Gong Z,Liu S,Chen X,Jiang Q,Hao J

    更新日期:2017-06-15 00:00:00

  • Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity.

    abstract::Myelin-specific encephalitogenic T cells, when passively transferred into rats or mice, cause an experimental autoimmune disease. Previous studies by our group have shown that (a) the same cells also significantly reduce post-traumatic degeneration in these animals after injury to the central nervous system, (b) this ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kipnis J,Mizrahi T,Yoles E,Ben-Nun A,Schwartz M

    更新日期:2002-09-01 00:00:00

  • Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats.

    abstract::Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

    更新日期:2002-07-01 00:00:00

  • Modulation of acetylcholine receptor function in TE671 (rhabdomyosarcoma) cells by non-AChR ligands: possible relevance to seronegative myasthenia gravis.

    abstract::The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Li Z,Forester N,Vincent A

    更新日期:1996-02-01 00:00:00

  • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta.

    abstract::M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

    更新日期:2009-05-29 00:00:00

  • Parental genes do not codominantly confer susceptibility to experimental autoimmune encephalomyelitis in F1 rats.

    abstract::Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbet...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lenz DC,Wolf NA,Swanborg RH

    更新日期:2001-03-01 00:00:00

  • Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation.

    abstract::Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

    更新日期:2001-01-01 00:00:00

  • Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.

    abstract::CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gong N,Liu J,Reynolds AD,Gorantla S,Mosley RL,Gendelman HE

    更新日期:2011-01-01 00:00:00

  • Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.

    abstract::Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

    更新日期:2009-08-18 00:00:00

  • The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.

    abstract::Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS) in which autoreactive immune cells recognizing myelin antigens lead to demyelination and axonal injury. Mechanisms relevant to the pathogenesis of MS have not been fully elucidated, particularly those underlying initiation of ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Selmaj I,Mycko MP,Raine CS,Selmaj KW

    更新日期:2017-05-15 00:00:00

  • Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 alpha in the inner ear.

    abstract::Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1. The increased VEGF production by DFX was inhibited by iron. DFX also induced the activation of mitogen-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jeong HJ,Kim JB,Hong SH,An NH,Kim MS,Park BR,Park RK,Kim HM

    更新日期:2005-06-01 00:00:00

  • Acute stress impairs NK cell adhesion and cytotoxicity through CD2, but not LFA-1.

    abstract::Using a nonhuman primate model, we examined the mechanisms by which acute social stress inhibits the ability of NK cells to form conjugates with, and lyse target cells. We examined the expression and role of the primary NK cell adhesion molecules, CD2 and LFA-1, in mediating conjugation to target cells. Acute stress i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rogers CJ,Brissette-Storkus CS,Chambers WH,Cameron JL

    更新日期:1999-10-29 00:00:00

  • Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines.

    abstract::The surface receptors involved in natural killer (NK) cell triggering during the process of target cell lysis have been at least in part identified. These are members of a novel family of receptors that has been termed natural cytotoxicity receptors (NCR). The first three members of this emerging group of receptors ar...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sivori S,Parolini S,Marcenaro E,Castriconi R,Pende D,Millo R,Moretta A

    更新日期:2000-07-24 00:00:00

  • Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.

    abstract::An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

    更新日期:1997-06-01 00:00:00

  • Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation.

    abstract::Natural killer (NK) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NK cell frequency in CSF was overall decreased compared to blood, particularly in MS p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,多中心研究


    authors: Hamann I,Dörr J,Glumm R,Chanvillard C,Janssen A,Millward JM,Paul F,Ransohoff RM,Infante-Duarte C

    更新日期:2013-01-15 00:00:00

  • Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus).

    abstract::Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Laman JD,van Meurs M,Schellekens MM,de Boer M,Melchers B,Massacesi L,Lassmann H,Claassen E,Hart BA

    更新日期:1998-06-01 00:00:00

  • Regulation of prolactin expression in leukemic cell lines and peripheral blood mononuclear cells.

    abstract::To address the role of different intracellular signals in prolactin (PRL) expression in leukocytes, we have investigated the effects of chlorophenylthio-cAMP (cptcAMP), phorbol myristate acetate (PMA) and ionomycin on the activation of the upstream PRL promoter in several leukemic cell lines. All three stimulators, al...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gerlo S,Vanden Berghe W,Verdood P,Hooghe-Peters EL,Kooijman R

    更新日期:2003-02-01 00:00:00

  • Initial characterization and autoradiographic localization of a novel sigma/opioid binding site in immune tissues.

    abstract::High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic si...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Whitlock BB,Liu Y,Chang S,Saini P,Ha BK,Barrett TW,Wolfe SA Jr

    更新日期:1996-07-01 00:00:00

  • Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta.

    abstract::Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats effectively ameliorated the disease, partially through a TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG rats was...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kong QF,Sun B,Bai SS,Zhai DX,Wang GY,Liu YM,Zhang SJ,Li R,Zhao W,Sun YY,Li N,Wang Q,Peng HS,Jin LH,Li HL

    更新日期:2009-02-15 00:00:00

  • Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis.

    abstract::Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

    更新日期:2007-02-01 00:00:00

  • Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells.

    abstract::Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF,...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

    更新日期:2006-02-01 00:00:00

  • Cultured astrocytes express regional heterogeneity of the immunoreactive phenotype under basal conditions and after gamma-IFN induction.

    abstract::Cerebral astrocytes are known to show a region-specific phenotype, concerning the expression of several receptors and the synthesis of secreted substances. In order to find out whether this heterogeneity also exists for the immunological activation, we studied several parameters that are known to characterize activate...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Morga E,Faber C,Heuschling P

    更新日期:1998-07-01 00:00:00

  • Psychopharmacological activity of immune complexes in rat brain is complement dependent.

    abstract::Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Schupf N,Williams CA

    更新日期:1987-01-01 00:00:00