Effects of acute treatment with amphetamine in locomotor activity in sepsis survivor rats.

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investi...

journal_title：Journal of neuroimmunology

authors： Peelen E,Thewissen M,Knippenberg S,Smolders J,Muris AH,Menheere P,Tervaert JW,Hupperts R,Damoiseaux J

更新日期：2013-05-15 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to neuromuscular junction (NMJ) damage by anti-acetylcholine receptor (AChR) auto-antibodies and complement. In experimental autoimmune myasthenia gravis (EAMG), which is induced by immunization with Torpedo AChR in CFA, anti-AChR IgG2b an...

journal_title：Journal of neuroimmunology

authors： Huda R,Strait RT,Tüzün E,Finkelman FD,Christadoss P

更新日期：2015-04-15 00:00:00

abstract：:A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

journal_title：Journal of neuroimmunology

authors： Walker AG,Chapman J,Bruce CB,Rumsby MG

更新日期：1984-11-01 00:00:00

abstract：:Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

journal_title：Journal of neuroimmunology

authors： Michalovicz LT,Lally B,Konat GW

更新日期：2015-08-15 00:00:00

abstract：:Using a nonhuman primate model, we examined the mechanisms by which acute social stress inhibits the ability of NK cells to form conjugates with, and lyse target cells. We examined the expression and role of the primary NK cell adhesion molecules, CD2 and LFA-1, in mediating conjugation to target cells. Acute stress i...

journal_title：Journal of neuroimmunology

authors： Rogers CJ,Brissette-Storkus CS,Chambers WH,Cameron JL

更新日期：1999-10-29 00:00:00

abstract：:There has been no data on oligoclonal IgG bands (OCBs) for Turkish MS population, who is believed to be placed between Western and Eastern world regarding the clinical and immunological features. In the present study, we examined the correlation between the frequency of OCB and clinical and demographical features of M...

journal_title：Journal of neuroimmunology

authors： Idiman E,Ozakbas S,Dogan Y,Kosehasanogullari G

更新日期：2009-07-25 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T helper 1 (Th1) cell mediated demyelinating disease and the principal animal model for multiple sclerosis. Spinal cords from SJL mice primed with proteolipid protein peptide 139-151 (pPLP) expressed the chemokines RANTES, MCP-1, MIP-2, KC, MIP-1alpha, MIP-1beta, Mi...

journal_title：Journal of neuroimmunology

authors： Fischer FR,Santambrogio L,Luo Y,Berman MA,Hancock WW,Dorf ME

更新日期：2000-10-02 00:00:00

abstract：:NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

journal_title：Journal of neuroimmunology

authors： Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

更新日期：2008-05-30 00:00:00

abstract：:Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3 signals ...

journal_title：Journal of neuroimmunology

authors： Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

更新日期：2020-06-15 00:00:00

abstract：:Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencep...

journal_title：Journal of neuroimmunology

authors： Wang T,Liu B,Qin L,Wilson B,Hong JS

更新日期：2004-02-01 00:00:00

abstract：:Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...

journal_title：Journal of neuroimmunology

authors： O'Shannessy DJ,Ilyas AA,Dalakas MC,Mendell JR,Quarles RH

更新日期：1986-04-01 00:00:00

abstract：:The interaction between lymphocytes and brain endothelium is a central pathogenetic event in CNS autoimmunity and, thus, represents an important focus of investigation. Chemokine binding through specific G protein-coupled receptors (GPCRs) on lymphocyte surface activates integrins and induces inside-out signaling and ...

journal_title：Journal of neuroimmunology

authors： Constantin G

更新日期：2008-07-31 00:00:00

abstract：:Research tools are urgently needed to elucidate the specificities of NMO and MS due to their clinical similarity at the early stage of the diseases. Herein, using high-field-strength MRI we characterized the optic nerve and spinal cord lesions in 2D2(tg) mice (MOG 35-55 specific TCR). Specifically, early Blood-brain B...

journal_title：Journal of neuroimmunology

authors： Bell JC,Liu Q,Gan Y,Liu Q,Liu Y,Shi FD,Turner GH

更新日期：2013-11-15 00:00:00

abstract：:In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incid...

journal_title：Journal of neuroimmunology

authors： Yin L,Chen Y,Qu Z,Zhang L,Wang Q,Zhang Q,Li L

更新日期：2014-09-15 00:00:00

abstract：:Using simultaneous dual direct immunofluorescence the effect of high dose intravenous methylprednisolone on the expression of T lymphocyte differentiation antigens in paired cerebrospinal fluid and peripheral blood samples of nine clinically active patients with multiple sclerosis was studied. Corticosteroid treatment...

journal_title：Journal of neuroimmunology

authors： Durelli L,Poccardi G,Cavallo R

更新日期：1991-03-01 00:00:00

abstract：:Brain levels of Ia mRNA, quantified by RNA blot analysis, were found to be 30-50-fold lower than splenic levels in all autoimmune and normal mouse strains examined except MRL/l, whose brain content of Ia mRNA was comparable to normal splenic levels. Prior perfusion to remove blood cells did not alter the amount of Ia ...

journal_title：Journal of neuroimmunology

authors： McIntyre KR,Ayer-LeLièvre C,Persson H

更新日期：1990-06-01 00:00:00

abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

journal_title：Journal of neuroimmunology

authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

更新日期：1984-09-01 00:00:00

abstract：:We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells fo...

journal_title：Journal of neuroimmunology

authors： Gangaplara A,Massilamany C,Steffen D,Reddy J

更新日期：2013-10-15 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：:Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equine encephalitis virus (VEEV)...

journal_title：Journal of neuroimmunology

authors： Cain MD,Salimi H,Gong Y,Yang L,Hamilton SL,Heffernan JR,Hou J,Miller MJ,Klein RS

更新日期：2017-07-15 00:00:00

abstract：:To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

journal_title：Journal of neuroimmunology

authors： Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

更新日期：1995-02-01 00:00:00

abstract：:Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF,...

journal_title：Journal of neuroimmunology

authors： Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

更新日期：2006-02-01 00:00:00

abstract：:Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the enceph...

journal_title：Journal of neuroimmunology

authors： Kostic M,Zivkovic N,Cvetanovic A,Stojanovic I

更新日期：2018-10-15 00:00:00

abstract：:Cerebral ischaemia is a common occurrence in a range of pathological conditions, including stroke and traumatic brain injury. Two of the components in ischaemia are tissue hypoxia and the release of pro-inflammatory agents such as TNF-alpha. The role of TNF-alpha in an ischaemic/hypoxic episode is still controversial,...

journal_title：Journal of neuroimmunology

authors： Batti L,O'Connor JJ

更新日期：2010-01-25 00:00:00

abstract：:Methylene blue (MB) is an effective neuroprotectant in many neurological disorders. AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1 (SIRT1) plays a crucial role in maintaining inflammatory responses and shows a synergistic effect on cell homeostasis. We investigated the effect...

journal_title：Journal of neuroimmunology

authors： Wang J,Zhao C,Kong P,Bian G,Sun Z,Sun Y,Guo L,Li B

更新日期：2016-10-15 00:00:00

abstract：:To clarify the origin and function of the microglia residing in the central nervous system, we cloned brain cells from newborn and adult mice in soft agar containing the macrophage-specific growth factor, colony-stimulating factor-1 and expanded the cells from individual colonies in liquid culture medium. The results ...

journal_title：Journal of neuroimmunology

authors： Moore SC,McCormack JM,Armendariz E,Gatewood J,Walker WS

更新日期：1992-12-01 00:00:00

abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Bealmear B

更新日期：1991-02-01 00:00:00

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00