当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Acute stress impairs NK cell adhesion and cytotoxicity through CD2, but not LFA-1.

Acute stress impairs NK cell adhesion and cytotoxicity through CD2, but not LFA-1.

Abstract：

:Using a nonhuman primate model, we examined the mechanisms by which acute social stress inhibits the ability of NK cells to form conjugates with, and lyse target cells. We examined the expression and role of the primary NK cell adhesion molecules, CD2 and LFA-1, in mediating conjugation to target cells. Acute stress induced a decrease in NK cell expression of CD2 (17+/-3%); and to a lesser degree induced a decrease in expression of LFA-1 (CD11a: 8+/-3%; CD18: 7+/-3%). Antibody blocking studies indicated that anti-LFA-1 significantly inhibited NK cell conjugate formation and cytotoxicity in both control (approximately 40% and approximately 50%, respectively) and stressed (approximately 20% and approximately 45%, respectively) conditions. However, anti-CD2 blocked conjugation and cytotoxicity in the control condition by approximately 50%, but had no capacity to further affect the inhibition of conjugation or cytotoxicity of NK cells induced by acute stress. These data indicate that there are differential effects of acute stress on the expression and function of LFA-1 and CD2, and that the stress-induced inhibition of NK cell adhesion and cytotoxicity is dependent upon modulation of adhesion and/or signalling through CD2.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Rogers CJ,Brissette-Storkus CS,Chambers WH,Cameron JL

doi

10.1016/s0165-5728(99)00125-3

subject

Has Abstract

pub_date

1999-10-29 00:00:00

pages

230-41

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572899001253

journal_volume

99

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • The pathology of multiple sclerosis: a historical perspective.

    abstract：:In the century and a half since multiple sclerosis (MS) was first recognized, the pathology of the condition has been defined with increasing detail. From the recognition and definition of MS as a clinical phenomenon, studies of the diseased brain tissue have progressed in a manner dependent on the science of the time...

    journal_title：Journal of neuroimmunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/s0165-5728(99)00079-x

    authors： Hickey WF

    更新日期：1999-07-01 00:00:00

  • Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies.

    abstract：:The two chemokines, monocyte chemoattractant protein (MCP)-1 and gamma-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and from 40 controls. The latter co...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-5728(01)00261-2

    authors： Franciotta D,Martino G,Zardini E,Furlan R,Bergamaschi R,Andreoni L,Cosi V

    更新日期：2001-04-02 00:00:00

  • Wallerian degeneration induces Ia-antigen expression in the rat brain.

    abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90132-x

    authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

    更新日期：1989-12-01 00:00:00

  • Increase of matrix metalloproteinase-9 in peripheral blood of multiple sclerosis patients treated with high doses of methylprednisolone.

    abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2003.10.046

    authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

    更新日期：2004-01-01 00:00:00

  • Regional suppression, therapy after onset and prevention of relapses in experimental allergic encephalomyelitis by mitoxantrone.

    abstract：:Mitoxantrone, a new antineoplastic anthracenedione drug, suppressed the development of experimental allergic encephalomyelitis (EAE) in rats when administered during the incubation period. One dose of mitoxantrone had a favorable effect on EAE even when withheld until after the onset of clinical signs. In a model of r...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(86)90063-9

    authors： Levine S,Saltzman A

    更新日期：1986-12-01 00:00:00

  • Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.

    abstract：:The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.04.002

    authors： Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G

    更新日期：2006-07-01 00:00:00

  • The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

    abstract：:Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to al...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.008

    authors： Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

    更新日期：2005-10-01 00:00:00

  • Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.

    abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.07.010

    authors： McCue D,Ryan KR,Wraith DC,Anderton SM

    更新日期：2004-11-01 00:00:00

  • Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

    abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.06.014

    authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

    更新日期：2010-10-08 00:00:00

  • Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

    abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.05.012

    authors： Tsunoda I,Libbey JE,Fujinami RS

    更新日期：2007-08-01 00:00:00

  • The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients.

    abstract：:Transcriptional dysregulation is a major pathological feature of Huntington's disease (HD). The goal of this study was to understand how p65/RelA co-regulated genes, specifically those of the cytokine and endocannabinoid systems, were affected in HD. p65/RelA levels were lower in human HD tissue and R6/2 HD mice, as w...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.12.008

    authors： Laprairie RB,Warford JR,Hutchings S,Robertson GS,Kelly ME,Denovan-Wright EM

    更新日期：2014-02-15 00:00:00

  • Epstein-Barr virus and multiple sclerosis: cellular immune response and cross-reactivity.

    abstract：:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.08.009

    authors： Lindsey JW,Hatfield LM

    更新日期：2010-12-15 00:00:00

  • Induction and regulation of interleukin-6 gene expression in rat astrocytes.

    abstract：:Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the cur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(90)90104-u

    authors： Benveniste EN,Sparacio SM,Norris JG,Grenett HE,Fuller GM

    更新日期：1990-12-01 00:00:00

  • Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse.

    abstract：:High doses of glucocorticoids (GCs) are widely employed to treat acute attacks in relapsing-remitting multiple sclerosis (MS) patients. Their beneficial effects are partially due to their capacity to regulate the cytokine network. In the present work, we have examined the effect of GCs on the production of the immunos...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00262-2

    authors： Gayo A,Mozo L,Suárez A,Tuñon A,Lahoz C,Gutiérrez C

    更新日期：1998-05-15 00:00:00

  • Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters.

    abstract：:A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.05.006

    authors： Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

    更新日期：2006-08-01 00:00:00

  • Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.

    abstract：:CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.06.010

    authors： Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

    更新日期：2008-09-15 00:00:00

  • Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia.

    abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.08.002

    authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

    更新日期：2018-11-15 00:00:00

  • Cytokine profile in patients with multiple sclerosis following vitamin D supplementation.

    abstract：:Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-5728(02)00396-x

    authors： Mahon BD,Gordon SA,Cruz J,Cosman F,Cantorna MT

    更新日期：2003-01-01 00:00:00

  • The differential expression and potential roles of circular RNAs in children with anti-NMDA receptor encephalitis.

    abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577381

    authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

    更新日期：2020-11-15 00:00:00

  • Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism.

    abstract：:Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.01.015

    authors： Boontanrart M,Hall SD,Spanier JA,Hayes CE,Olson JK

    更新日期：2016-03-15 00:00:00

  • Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica.

    abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.05.007

    authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

    更新日期：2015-06-15 00:00:00

  • Structure of epitopes recognized by the antibodies to alpha(181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain.

    abstract：:Using the alpha(181-192) peptides of neuronal nicotinic acetylcholine receptor (nAChR) and Ala-substituted peptide analogues, amino acid residues critical for specific monoclonal antibody (mAb) binding were identified. By means of 2D nuclear magnetic resonance (2D-NMR) analysis followed by molecular modeling, it was f...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00437-4

    authors： Skok M,Lykhmus E,Bobrovnik S,Tzartos S,Tsouloufis T,Vanderesse R,Coutrot F,Thong Cung M,Marraud M,Krikorian D,Sakarellos-Daitsiotis M

    更新日期：2001-12-03 00:00:00

  • Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRV beta 6 CDR2 peptide.

    abstract：:We report here the results of a phase I trial of a T-cell receptor (TCR) V beta 6 CDR2 region peptide vaccine in 10 patients with multiple sclerosis who showed biased over-representations of V beta 6 mRNA among T-cells in their cerebrospinal fluids (CSF). One group of 5 patients was immunized twice during a four week ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-5728(97)00029-5

    authors： Gold DP,Smith RA,Golding AB,Morgan EE,Dafashy T,Nelson J,Smith L,Diveley J,Laxer JA,Richieri SP,Carlo DJ,Brostoff SW,Wilson DB

    更新日期：1997-06-01 00:00:00

  • The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.

    abstract：:The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.04.004

    authors： Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

    更新日期：2018-07-15 00:00:00

  • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta.

    abstract：:M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.02.003

    authors： Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

    更新日期：2009-05-29 00:00:00

  • Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis.

    abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.12.015

    authors： Storer PD,Xu J,Chavis J,Drew PD

    更新日期：2005-04-01 00:00:00

  • Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis.

    abstract：:Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.10.021

    authors： Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

    更新日期：2007-02-01 00:00:00

  • Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis.

    abstract：:The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of N...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00352-0

    authors： Schluesener HJ,Seid K

    更新日期：2000-10-02 00:00:00

  • Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R.

    abstract：:Substance P (SP) can produce cytokine-like responses by astrocytes and mononuclear cells. In an effort to identify neurokinin-1-receptors (NK1-R), an antibody to NK1-R was generated by using a linear peptide sequence from the deduced third extracellular region (ECR) corresponding to the seven transmembrane rat brain N...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00033-1

    authors： van Ginkel FW,Pascual DW

    更新日期：1996-06-01 00:00:00

  • Psychopharmacological activity of immune complexes in rat brain is complement dependent.

    abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90065-8

    authors： Schupf N,Williams CA

    更新日期：1987-01-01 00:00:00