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Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody.

Abstract：

:This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring-summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn-winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Akaishi T,Fujimori J,Takahashi T,Misu T,Takai Y,Nishiyama S,Kaneko K,Ogawa R,Abe M,Ishii T,Aoki M,Fujihara K,Nakashima I

doi

10.1016/j.jneuroim.2020.577431

subject

Has Abstract

pub_date

2020-12-15 00:00:00

pages

577431

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(20)30692-5

journal_volume

349

pub_type

杂志文章,多中心研究

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