A role for reactive oxygen species in endotoxin-induced elevation of MOR expression in the nervous and immune systems.

abstract：:The capacity of rat cerebral endothelial cells (RCEC) to form eicosanoids was determined after incubation with 14C-labelled arachidonic acid. Prostaglandin E2 (PGE2) was the main metabolite formed by RCEC and was responsible for 54% of the total amount of eicosanoids produced. In contrast, in primary cultures of rat a...

journal_title：Journal of neuroimmunology

authors： de Vries HE,Hoogendoorn KH,van Dijk J,Zijlstra FJ,van Dam AM,Breimer DD,van Berkel TJ,de Boer AG,Kuiper J

更新日期：1995-06-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

journal_title：Journal of neuroimmunology

authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

更新日期：2019-02-15 00:00:00

abstract：:Ischemic stroke is one of the leading causes of mortality and morbidity in humans. During brain ischemia and the subsequent reperfusion that occurs with stroke, the generation of the so-called "proinflammatory" prostaglandin E(2) (PGE(2)) increases significantly. Therefore, interest is growing regarding the differenti...

journal_title：Journal of neuroimmunology

authors： Saleem S,Kim YT,Maruyama T,Narumiya S,Doré S

更新日期：2009-03-31 00:00:00

abstract：:We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included mRNAs encoding the transcriptional factors, IRF-1,...

journal_title：Journal of neuroimmunology

authors： Vanguri P

更新日期：1995-01-01 00:00:00

abstract：:Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...

journal_title：Journal of neuroimmunology

authors： Lin L,Hungs M,Mignot E

更新日期：2001-07-02 00:00:00

abstract：:The objective of this article is to discuss the putative role of cannabinoid receptors in immune modulation by cannabinoid compounds. The primary focus is on the signal transduction events that are initiated following ligand binding to cannabinoid receptors and how these events lead to detrimental effects on the norma...

journal_title：Journal of neuroimmunology

authors： Kaminski NE

更新日期：1998-03-15 00:00:00

abstract：:There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but there is no direct evidence that TNF can produce demyelination in the central nervous system (CNS). We demonstrate here that single injections of TNF into the dors...

journal_title：Journal of neuroimmunology

authors： Hall SM,Redford EJ,Smith KJ

更新日期：2000-07-01 00:00:00

abstract：:Carbon nantotubes (CNTs) are emerging as a new family of nanovectors for drug and gene delivery into biological systems. To evaluate potential application of this technology for brain tumor therapy, we studied uptake and toxicity of multi-walled CNTs (MWCNTs) in the GL261 murine intracranial glioma model. Within 24 h ...

journal_title：Journal of neuroimmunology

authors： VanHandel M,Alizadeh D,Zhang L,Kateb B,Bronikowski M,Manohara H,Badie B

更新日期：2009-03-31 00:00:00

abstract：:Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflam...

journal_title：Journal of neuroimmunology

authors： Feng N,Jia Y,Huang X

更新日期：2019-09-15 00:00:00

abstract：:The blood brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB) limit the influx of immune mediators and bloodstream compounds into the central nervous system (CNS). Upon injury or infection, the integrity of these barriers is compromised and leukocyte infiltration occurs. The BCB is located in the choro...

journal_title：Journal of neuroimmunology

authors： Alvarez JI,Teale JM

更新日期：2007-07-01 00:00:00

abstract：:Thymic tissues express transcripts encoding the alpha-3, alpha-5 and beta-4 subunits of nicotinic neuronal acetylcholine receptors (AcChRs) suggesting that neuronal AcChRs similar to those expressed in ganglia are expressed in the thymus. Transcription occurs in both isolated thymocytes and thymic epithelial cells. RT...

journal_title：Journal of neuroimmunology

authors： Mihovilovic M,Denning S,Mai Y,Whichard LP,Patel DD,Roses AD

更新日期：1997-11-01 00:00:00

abstract：:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology and pathogenesis of MS and NMOSD remain unclear. The pathogenesis of these two diseases involves a genetic predisposition as well as environmental factors. NMOSD som...

journal_title：Journal of neuroimmunology

authors： Liang H,Gao W,Liu X,Liu J,Mao X,Yang M,Long X,Zhou Y,Zhang Q,Zhu J,Wang S,Jin T

更新日期：2019-12-15 00:00:00

abstract：:The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of N...

journal_title：Journal of neuroimmunology

authors： Schluesener HJ,Seid K

更新日期：2000-10-02 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：:Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evalu...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Vieira ÉLM,Dos Reis Bastos J,Ferreira RN,Nicoli JR,Teixeira MM,Vieira LQ,Moreira FA,Teixeira AL

更新日期：2020-06-16 00:00:00

abstract：:The central nervous system (CNS) enjoys a unique relationship with the immune system. Under non-pathological conditions, T cells move through the CNS but do not accumulate there. CNS trauma has been shown to trigger a response to CNS self-antigens such as myelin basic protein (MBP). Here, we examined whether the injur...

journal_title：Journal of neuroimmunology

authors： Hirschberg DL,Moalem G,He J,Mor F,Cohen IR,Schwartz M

更新日期：1998-08-14 00:00:00

abstract：:Brain levels of Ia mRNA, quantified by RNA blot analysis, were found to be 30-50-fold lower than splenic levels in all autoimmune and normal mouse strains examined except MRL/l, whose brain content of Ia mRNA was comparable to normal splenic levels. Prior perfusion to remove blood cells did not alter the amount of Ia ...

journal_title：Journal of neuroimmunology

authors： McIntyre KR,Ayer-LeLièvre C,Persson H

更新日期：1990-06-01 00:00:00

abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

journal_title：Journal of neuroimmunology

authors： Tsunoda I,Libbey JE,Fujinami RS

更新日期：2007-08-01 00:00:00

abstract：:This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulatio...

journal_title：Journal of neuroimmunology

authors： Backonja MM,Coe CL,Muller DA,Schell K

更新日期：2008-03-01 00:00:00

abstract：:To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with ...

journal_title：Journal of neuroimmunology

authors： Ogata H,Isobe N,Zhang X,Yamasaki R,Fujii T,Machida A,Morimoto N,Kaida K,Masuda T,Ando Y,Kuwahara M,Kusunoki S,Nakamura Y,Matsushita T,Kira JI

更新日期：2020-02-15 00:00:00

abstract：:In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

journal_title：Journal of neuroimmunology

authors： Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

更新日期：1998-02-01 00:00:00

abstract：:The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

journal_title：Journal of neuroimmunology

authors： Huang DR,Pirskanen R,Matell G,Lefvert AK

更新日期：1999-02-01 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:B lymphocytes play an important role in the pathogenesis of multiple sclerosis (MS). Follicle-like structures (FLS) have recently been found in the subarachnoid space in the leptomeninges in some patients with secondary progressive MS (SPMS). They contain proliferating B lymphocytes, plasma cells, helper T lymphocytes...

journal_title：Journal of neuroimmunology

authors： Haugen M,Frederiksen JL,Degn M

更新日期：2014-08-15 00:00:00

abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

journal_title：Journal of neuroimmunology

authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

journal_title：Journal of neuroimmunology

authors： Belinga VF,Wu GJ,Yan FL,Limbenga EA

更新日期：2016-04-15 00:00:00

abstract：:Previously, we found that in rats coagulation of the lateral hypothalamus (LH) caused depression of the peripheral blood natural killer cell cytotoxicity (NKCC) and the number of large granular lymphocytes (LGL). In the present work, we have tested the effects on both spleen and blood NKCC of acute (1 day) and chronic...

journal_title：Journal of neuroimmunology

authors： Wrona D,Trojniar W

更新日期：2003-08-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately...

journal_title：Journal of neuroimmunology

authors： Dijkstra CD,De Groot CJ,Huitinga I

更新日期：1992-10-01 00:00:00

abstract：:The mechanisms by which autoimmune diseases are triggered and by which the activation of autoreactive T cells is initiated and maintained are not yet fully understood. As the most potent antigen presenting cells (APC), and also being responsible for antigen transport as well as primary sensitisation of T cells, dendri...

journal_title：Journal of neuroimmunology

authors： Link H,Huang YM,Xiao BG

更新日期：1999-12-01 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00