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MP4- and MOG:35-55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum.

Abstract：

:Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout the disease, in MP4-induced EAE it was dynamic and stage-dependent shifting from the brain to the spinal cord and finally to the cerebellum. Unlike in the MOG peptide model, the frequencies and sizes of CNS lesions in MP4-induced disease showed a clear correlation with clinical disease severity. These characteristic features of MP4-induced EAE may contribute to modelling the complex spectrum of disease manifestations seen in MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kuerten S,Kostova-Bales DA,Frenzel LP,Tigno JT,Tary-Lehmann M,Angelov DN,Lehmann PV

doi

10.1016/j.jneuroim.2007.06.016

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

31-40

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(07)00215-9

journal_volume

189

pub_type

杂志文章

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