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Endogenous spinal cord stem cells in multiple sclerosis and its animal model.

Abstract：

:The adult mammalian spinal cord (SC) harbors neural stem cells (NSCs). The SC-NSCs are mostly quiescent during physiological conditions but are quickly activated in traumatic injury models. The SC-NSCs generate mostly glia, but are able to differentiate into neurons when affected by favourable conditions. An example is the inflammatory milieu in the SC of rat EAE, where the SC-NSCs migrate into demyelinated lesions and give rise to both glia and neurons. In MS, cells with progenitor phenotypes accumulate in inflammatory lesions both in brain and SC, but the extent to which these cells contribute to repair remains to be revealed.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Covacu R,Brundin L

doi

10.1016/j.jneuroim.2016.11.006

subject

Has Abstract

pub_date

2019-06-15 00:00:00

pages

4-10

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30403-9

journal_volume

331

pub_type

杂志文章,评审

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