Abstract:
:Changes in mitogen-induced splenocyte proliferation and NK activity were evaluated after acute (1 h) and chronic (6 d) in vivo treatment of rats with the synthetic cannabinoid compound CP-55,940. At a dose of 0.4 mg/kg i.p. it significantly inhibited the splenocyte proliferative response to PHA and NK activity but half this dose (0.2 mg/kg) had no effect on immune responses. Pretreatment of rats with the cannabinoid receptor CB1 antagonist SR141716A did not antagonize the CP-55,940-induced immunosuppression, excluding the activation of this receptor subtype in the mediation of this effect. When immune function studies were done on rats tolerant to CP-55,940-induced analgesia, full tolerance also developed for the inhibition of splenocyte proliferation and NK activity. The data provided indicate that CB1 cannabinoid receptors are not involved in mediating the acute and chronic effects of cannabinoids on the immune system and suggest a possible implication of CB2 receptor although other modalities of CP-55,940 action can not be ruled out.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Patrini G,Sacerdote P,Fuzio D,Manfredi B,Parolaro Ddoi
10.1016/s0165-5728(97)00149-5subject
Has Abstractpub_date
1997-12-01 00:00:00pages
143-8issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(97)00149-5journal_volume
80pub_type
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