Pharmacological modulation of neuropeptides in peripheral mononuclear cells.

Abstract:

:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased after treatment with serotoninergic agonists, decreased after dopaminergic or GABAergic drugs, while the respective antagonists exerted the opposite effect. In vitro, serotoninergic and GABAergic compounds confirmed their roles in the modulation of beta-endorphin in mononuclear cells. Cholecystokinin was never affected by the pharmacological treatments.

journal_name

J Neuroimmunol

authors

Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE

doi

10.1016/0165-5728(91)90069-j

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

35-41

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(91)90069-J

journal_volume

32

pub_type

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