Pharmacological modulation of neuropeptides in peripheral mononuclear cells.


:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased after treatment with serotoninergic agonists, decreased after dopaminergic or GABAergic drugs, while the respective antagonists exerted the opposite effect. In vitro, serotoninergic and GABAergic compounds confirmed their roles in the modulation of beta-endorphin in mononuclear cells. Cholecystokinin was never affected by the pharmacological treatments.


J Neuroimmunol


Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE




Has Abstract


1991-04-01 00:00:00














  • The effect of acute immobilization stress on the abundance of corticotropin-releasing factor receptor in lymphoid organs.

    abstract::We have previously found a dramatic increase of corticotropin-releasing factor receptor (CRF-R1) production in splenic neutrophils of male C57BL/6N mice after application of an immunological stimulus. We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect. Shortly aft...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Radulovic M,Weber C,Spiess J

    更新日期:2000-03-01 00:00:00

  • Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.

    abstract::Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hilliard A,Mendonca P,Soliman KFA

    更新日期:2020-08-15 00:00:00

  • The intrathecal polyspecific antiviral immune response (MRZ reaction): A potential cerebrospinal fluid marker for multiple sclerosis diagnosis.

    abstract::We tested the performance of MRZ-reaction, an intrathecal humoral immune response against-Measles (M), Rubella (R) and Varicella Zoster (Z) viruses, in multiple sclerosis (MS) diagnosis. The MRZ-reaction was significantly more positive in MS than in non-MS group with a specificity of 91.9%. In MS group, the RZ-profile...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Feki S,Gargouri S,Mejdoub S,Dammak M,Hachicha H,Hadiji O,Feki L,Hammami A,Mhiri C,Karray H,Masmoudi H

    更新日期:2018-08-15 00:00:00

  • Role of the innate immune system in the pathogenesis of multiple sclerosis.

    abstract::Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we have discussed the ro...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Gandhi R,Laroni A,Weiner HL

    更新日期:2010-04-15 00:00:00

  • Preferential association of V lambda x light chains with gamma 2a heavy chains in naturally occurring human myelin basic protein reactive antibodies.

    abstract::Active immunization with myelin basic protein (MBP) induces experimental allergic encephalomyelitis (EAE) in a variety of animal species, including rats and mice. We have previously described the ability of the newly described mouse lambda (lambda) variable (V) region V lambda x, to confer MBP reactivity to an Ab. In ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Galin FS,Zhou SR,Whitaker JN,Blalock JE

    更新日期:1996-10-01 00:00:00

  • Corticotropin-releasing hormone is involved in conditioned stimulus-induced reduction of natural killer cell activity but not in conditioned alterations in cytokine production or proliferation responses.

    abstract::Research from our laboratory has demonstrated that the presentation of an aversive conditioned stimulus produces pronounced suppression of several in vitro measures of immune status. The present study was designed to evaluate the role of central corticotropin-releasing hormone (CRH) in the mechanisms mediating these c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Perez L,Lysle DT

    更新日期:1995-12-01 00:00:00

  • B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients.

    abstract::In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

    更新日期:2014-07-15 00:00:00

  • Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?

    abstract::Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Conrady CD,Drevets DA,Carr DJ

    更新日期:2010-03-30 00:00:00

  • Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

    abstract::Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha1beta1+PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, th...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sinha S,Miller L,Subramanian S,McCarty OJ,Proctor T,Meza-Romero R,Huan J,Burrows GG,Vandenbark AA,Offner H

    更新日期:2010-08-25 00:00:00

  • Sudden hearing loss as the initial symptom in Japanese patients with multiple sclerosis and seropositive neuromyelitis optica spectrum disorders.

    abstract::Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tanaka M,Tanaka K

    更新日期:2016-09-15 00:00:00

  • Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients.

    abstract::The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Krestova M,Ricny J,Bartos A

    更新日期:2018-09-15 00:00:00

  • Age dependent course of EAE in Aire-/- mice.

    abstract::This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

    更新日期:2013-09-15 00:00:00

  • Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

    abstract::The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

    更新日期:2008-08-30 00:00:00

  • Native versus deglycosylated IgM in anti-MAG neuropathy: Correlation with clinical status - Study of 10 cases.

    abstract:BACKGROUND/PURPOSE:In anti-myelin associated glycoprotein (anti-MAG) neuropathies, there is evidence that anti-MAG antibodies are pathogenic but numerous studies report the absence or a weak correlation between the titers of these antibodies and disease course. In this study we assessed the relationships between MAG an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Neil J,Choumet V,Beadon K,Delmont E,Ghillani P,Boucraut J,Musset L,Léger JM

    更新日期:2020-02-15 00:00:00

  • Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls.

    abstract::Administration of beta-receptor agonists alleviate experimental multiple sclerosis (MS) in animal models. In this study, we investigated the effects of terbutaline (5 mg) on IL-10, IL-12, IFN-gamma and TNF-alpha production in whole blood stimulation cultures. IL-10 and IL-12 production were significantly enhanced in c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Heesen C,Gold SM,Sondermann J,Tessmer W,Schulz KH

    更新日期:2002-11-01 00:00:00

  • Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome.

    abstract::Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

    更新日期:2009-05-29 00:00:00

  • Expression profile of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells from myasthenia gravis patients.

    abstract::For the epigenetic characterization of myasthenia gravis (MG), we determined whether long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) are expressed differentially in subjects with and without MG. Compared with healthy control subjects, the MG patients had 1561 upregulated lncRNAs, 1034 downregulated lncRNAs, 9...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zhang F,Liu G,Bu Y,Ma X,Hao J

    更新日期:2016-10-15 00:00:00

  • Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation.

    abstract::Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Saab CY,Shamaa F,El Sabban ME,Safieh-Garabedian B,Jabbur SJ,Saadé NE

    更新日期:2009-03-31 00:00:00

  • Role of IL-5 during primary and secondary immune response to acetylcholine receptor.

    abstract::To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Poussin MA,Goluszko E,Franco JU,Christadoss P

    更新日期:2002-04-01 00:00:00

  • Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.

    abstract::The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G

    更新日期:2006-07-01 00:00:00

  • Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM.

    abstract::The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturall...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gilmore W,Moradzadeh DS

    更新日期:1993-10-01 00:00:00

  • Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.

    abstract::TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

    更新日期:2005-11-01 00:00:00

  • Molecular cloning of cDNAs for immunoglobulin variable regions of a monoclonal anti-idiotypic antibody specific for sigma receptors.

    abstract::In previous work on sigma (sigma) receptors, we established a hybridoma cell line, 10G9, producing a monoclonal anti-idiotypic antibody (anti-Id mAb) to the monoclonal and anti-haloperidol antibody. The anti-Id mAb showed specific binding affinity to sigma receptors in immunoprecipitation and competition experiments. ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kobayashi T,Togashi S,Itoh N,Kumanishi T

    更新日期:1995-03-01 00:00:00

  • Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes.

    abstract::Intercellular adhesion molecule-1 (ICAM-1) is a cell surface glycoprotein which can be induced on astrocytes, the major glial cell of the central nervous system (CNS). In this study, we examined the effect of three proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Shrikant P,Chung IY,Ballestas ME,Benveniste EN

    更新日期:1994-05-01 00:00:00

  • False positive immunoassay for acetyl choline receptor antibody (AChR Ab) in patients exposed to polyvalent antisnake venom.

    abstract::Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

    更新日期:2017-10-15 00:00:00

  • Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients.

    abstract::The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydroc...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章


    authors: Provencio JJ,Kivisäkk P,Tucky BH,Luciano MG,Ransohoff RM

    更新日期:2005-06-01 00:00:00

  • Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.

    abstract::Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wang YJ,Wang X,Zhang H,Zhou L,Liu S,Kolson DL,Song L,Ye L,Ho WZ

    更新日期:2009-01-03 00:00:00

  • Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats.

    abstract::We investigated T cell epitopes of guinea pig myelin basic protein (MBP) that induce experimental autoimmune encephalomyelitis (EAE) in DA rats, using synthetic peptides that correspond to regions of the guinea pig MBP molecule that are homologous to rat MBP. Four peptides were encephalitogenic when tested in DA rats....

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Stepaniak JA,Wolf NA,Sun D,Swanborg RH

    更新日期:1997-09-01 00:00:00

  • Tacrolimus-induced severe headache associated with diffuse leukoencephalopathy: Evidence for an immune-mediated pathogenesis.

    abstract::Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrol...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Smeralda CL,Gigli GL,Vogrig A,Marini A,Valente M

    更新日期:2019-05-15 00:00:00

  • Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines.

    abstract::The surface receptors involved in natural killer (NK) cell triggering during the process of target cell lysis have been at least in part identified. These are members of a novel family of receptors that has been termed natural cytotoxicity receptors (NCR). The first three members of this emerging group of receptors ar...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sivori S,Parolini S,Marcenaro E,Castriconi R,Pende D,Millo R,Moretta A

    更新日期:2000-07-24 00:00:00