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The cell cycle dependence of protein synthesis during Xenopus laevis development.

Abstract：

:The regulation of early embryonic development in the amphibian Xenopus laevis depends largely upon translational and post-translational regulatory mechanisms to direct the complex cytodifferentiations that take place during early cleavage and blastula formation. The cell cycle dependence of protein synthesis was examined in developing Xenopus embryos as well as in cycling cell-free lysates from Xenopus eggs. In both cases M-phase and the activation of the M-phase kinase were found to be correlated with an inhibition of translation. Translation in both the rough endoplasmic reticulum and cytosolic-free ribosomes were affected by this inhibition. Since elongation was found to be unaffected by M-phase, shifts in the polysome profiles during M-phase indicated that the inhibition affected initiation processes. The activity of the M-phase kinase may inhibit initiation through the modification of initiation factors or some other component during this process. The cell cycle dependence of translation may affect developmental mechanisms controlled by the titration of regulatory proteins.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Kanki JP,Newport JW

doi

10.1016/0012-1606(91)90460-k

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

198-213

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(91)90460-K

journal_volume

146

pub_type

杂志文章

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