abstract：:Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but the expression of Caudal in extant groups is varied and often occurs in other ...

journal_title：Developmental biology

authors： Johnson AB,Lambert JD

更新日期：2021-02-01 00:00:00

abstract：:During heart formation, the heart grows and undergoes dramatic morphogenesis to achieve efficient embryonic function. Both in fish and amniotes, much of the growth occurring after initial heart tube formation arises from second heart field (SHF)-derived progenitor cell addition to the arterial pole, allowing chamber f...

journal_title：Developmental biology

authors： Kula-Alwar D,Marber MS,Hughes SM,Hinits Y

更新日期：2021-02-01 00:00:00

abstract：:Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli. The mechanisms that coordinate dendrite extension with cilium position during sensory neuron development are not well understood. Here, we show that GRDN-1, ...

journal_title：Developmental biology

authors： Nechipurenko I,Lavrentyeva S,Sengupta P

更新日期：2021-01-16 00:00:00

abstract：:The vertebrate eye anlage grows out of the brain and folds into bilayered optic cups. The eye is patterned along multiple axes, precisely controlled by genetic programs, to delineate neural retina, pigment epithelium, and optic stalk tissues. Pax genes encode developmental regulators of key morphogenetic events, with ...

journal_title：Developmental biology

authors： Bosze B,Suarez-Navarro J,Soofi A,Lauderdale JD,Dressler GR,Brown NL

更新日期：2021-01-09 00:00:00

abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...

journal_title：Developmental biology

authors： Carlantoni C,Allanki S,Kontarakis Z,Rossi A,Piesker J,Günther S,Stainier DYR

更新日期：2021-01-01 00:00:00

abstract：:How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila. JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the...

journal_title：Developmental biology

authors： Ahmad V,Vadla GP,Chabu CY

更新日期：2021-01-01 00:00:00

abstract：:During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...

journal_title：Developmental biology

authors： Farrera-Hernández A,Marín-Llera JC,Chimal-Monroy J

更新日期：2021-01-01 00:00:00

abstract：:A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is governed by cell position-dependent Hippo signaling, which is a phosphorylation ...

journal_title：Developmental biology

authors： Yamamura S,Goda N,Akizawa H,Kohri N,Balboula AZ,Kobayashi K,Bai H,Takahashi M,Kawahara M

更新日期：2020-12-01 00:00:00

abstract：:The cnidarian "planula" larva shows radial symmetry around a polarized, oral-aboral, body axis and comprises two epithelia cell layers, ectodermal and endodermal. This simple body plan is set up during gastrulation, a process which proceeds by a variety of modes amongst the diverse cnidarian species. In the hydrozoan ...

journal_title：Developmental biology

authors： Kraus Y,Chevalier S,Houliston E

更新日期：2020-12-01 00:00:00

abstract：:Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major cha...

journal_title：Developmental biology

authors： Palacios-Martinez J,Caballero-Perez J,Espinal-Centeno A,Marquez-Chavoya G,Lomeli H,Salas-Vidal E,Schnabel D,Chimal-Monroy J,Cruz-Ramirez A

更新日期：2020-10-01 00:00:00

abstract：:Multiciliated cells (MCCs) differentiate hundreds of motile cilia that beat to drive fluid movement over various kinds of epithelia. In Xenopus, mice and human, the coiled-coil containing protein Mcidas (Mci) has been shown to be a key transcriptional regulator of MCC differentiation. We have examined Mci function in ...

journal_title：Developmental biology

authors： Zhou F,Rayamajhi D,Ravi V,Narasimhan V,Chong YL,Lu H,Venkatesh B,Roy S

更新日期：2020-09-15 00:00:00

abstract：:Development of the craniofacial structures requires the precise differentiation of cranial neural crest cells into osteoblasts or chondrocytes. Here, we explore the epigenetic and non-epigenetic mechanisms that are required for the development of craniofacial chondrocytes. We previously demonstrated that the acetyltra...

journal_title：Developmental biology

authors： Pezoa SA,Artinger KB,Niswander LA

更新日期：2020-08-01 00:00:00

abstract：:Non-syndromic mitral valve prolapse (MVP) is the most common heart valve disease affecting 2.4% of the population. Recent studies have identified genetic defects in primary cilia as causative to MVP, although the mechanism of their action is currently unknown. Using a series of gene inactivation approaches, we define ...

journal_title：Developmental biology

authors： Fulmer D,Toomer KA,Glover J,Guo L,Moore K,Moore R,Stairley R,Gensemer C,Abrol S,Rumph MK,Emetu F,Lipschutz JH,McDowell C,Bian J,Wang C,Beck T,Wessels A,Renault MA,Norris RA

更新日期：2020-07-01 00:00:00

abstract：:Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro ...

journal_title：Developmental biology

authors： Ban Z,Knöspel F,Schneider MR

更新日期：2020-07-01 00:00:00

abstract：:Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...

journal_title：Developmental biology

authors： Zheng C,Schneider JW,Hsieh J

更新日期：2020-06-15 00:00:00

abstract：:Xenopus laevis frogs from laboratory stocks normally lay eggs exhibiting extensive size variability. We find that these initial size differences subsequently affect the size of the embryos prior to the onset of growth, and the size of tadpoles during the growth period. Even though these tadpoles differ in size, their ...

journal_title：Developmental biology

authors： Leibovich A,Edri T,Klein SL,Moody SA,Fainsod A

更新日期：2020-06-15 00:00:00

abstract：:Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...

journal_title：Developmental biology

authors： Houssin NS,Martin JB,Coppola V,Yoon SO,Plageman TF Jr

更新日期：2020-06-01 00:00:00

abstract：:Inhibitor of differentiation and DNA-binding (Id) proteins, Id1 to Id4, function in the regulation of cellular proliferation and differentiation. Id proteins have been shown to interact with bHLH proteins and other proteins involved in regulating cellular proliferation and differentiation, suggesting a widespread regu...

journal_title：Developmental biology

authors： Sakamoto S,Tateya T,Omori K,Kageyama R

更新日期：2020-04-15 00:00:00

abstract：:Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate bord...

journal_title：Developmental biology

authors： Pegge J,Tatsinkam AJ,Rider CC,Bell E

更新日期：2020-04-15 00:00:00

abstract：:To investigate the spatiotemporal dynamics of skin pattern formation, we developed a simple method for artificially disarranging the placement of all three pigment cell types in the body trunk of zebrafish (Danio rerio). We generated transgenic fish with melanophores that ectopically expressed a variant of channelrhod...

journal_title：Developmental biology

authors： Aramaki T,Kondo S

更新日期：2020-04-01 00:00:00

abstract：:Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function ...

journal_title：Developmental biology

authors： Rachev E,Schuster-Gossler K,Fuhl F,Ott T,Tveriakhina L,Beckers A,Hegermann J,Boldt K,Mai M,Kremmer E,Ueffing M,Blum M,Gossler A

更新日期：2020-03-15 00:00:00

abstract：:The current academic and business landscape does not provide a clear path for doctoral trainees graduating. Moreover, the fundamental need of the hour is diversification of the workforce where PhD graduates need to be trained to do more beyond basic scientific research. One of the possible paths that is now becoming p...

journal_title：Developmental biology

authors： Sachani SS

更新日期：2020-03-01 00:00:00

abstract：:The N-ethyl-N-nitrosourea (ENU) ←forward genetic screen is a useful tool for the unbiased discovery of novel mechanisms regulating developmental processes. We recovered the dorothy mutation in such a screen designed to recover recessive mutations affecting craniofacial development in the mouse. Dorothy embryos die pre...

journal_title：Developmental biology

authors： DiStasio A,Paulding D,Chaturvedi P,Stottmann RW

更新日期：2020-02-15 00:00:00

abstract：:Much of boundary formation during development remains to be understood, despite being a defining feature of many animal taxa. Axial patterning of Hydra, a member of the ancient phylum Cnidaria which diverged prior to the bilaterian radiation, involves a steady-state of production and loss of tissue, and is dependent o...

journal_title：Developmental biology

authors： López-Quintero JA,Torres GG,Neme R,Bosch TCG

更新日期：2020-02-15 00:00:00

abstract：:In ascidian embryos, the earliest transcription from the zygotic genome begins between the 8-cell and 16-cell stages. Gata.a, a maternally expressed Gata transcription factor, activates target genes specifically in the animal hemisphere, whereas the complex of β-catenin and Tcf7 antagonizes the activity of Gata.a and ...

journal_title：Developmental biology

authors： Imai KS,Kobayashi K,Kari W,Rothbächer U,Ookubo N,Oda-Ishii I,Satou Y

更新日期：2020-02-15 00:00:00

abstract：:The cellular mechanisms underlying the amazing ability of sea cucumbers to regenerate their autotomized intestines have been widely described by us and others. However, the signaling pathways that control these mechanisms are unknown. Previous studies have shown that Wnt homologs are upregulated during early intestina...

journal_title：Developmental biology

authors： Bello SA,Torres-Gutiérrez V,Rodríguez-Flores EJ,Toledo-Román EJ,Rodríguez N,Díaz-Díaz LM,Vázquez-Figueroa LD,Cuesta JM,Grillo-Alvarado V,Amador A,Reyes-Rivera J,García-Arrarás JE

更新日期：2020-02-01 00:00:00

abstract：:During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone formation and the future length of the skeletal elements. A variety of transcription factors are expressed at the onset of hypertrophy coordinating the expression of differen...

journal_title：Developmental biology

authors： Wuelling M,Schneider S,Schröther VA,Waterkamp C,Hoffmann D,Vortkamp A

更新日期：2020-01-01 00:00:00

abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

journal_title：Developmental biology

authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

更新日期：2020-01-01 00:00:00

abstract：:The regeneration of lost body parts is a fascinating phenomenon exhibited by some multicellular organisms. In social amoebae, such as Dictyostelium discoideum, the pseudoplasmodium is a temporary migratory multicellular structure with high regeneration ability. It consists of future stalk cells (prestalk cells) at the...

journal_title：Developmental biology

authors： Mohri K,Tanaka R,Nagano S

更新日期：2020-01-01 00:00:00

abstract：:The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

journal_title：Developmental biology

authors： Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

更新日期：2019-12-01 00:00:00

abstract：:The current strategy to preserve fertility of male prepubertal cancer patients consists of cryopreservation of a testicular tissue biopsy containing spermatogonial stem cells (SSCs). While in humans, fertility restoration strategies from prepubertal testicular tissues are still under investigation and have not yet res...

journal_title：Developmental biology

authors： Portela JMD,Mulder CL,van Daalen SKM,de Winter-Korver CM,Stukenborg JB,Repping S,van Pelt AMM

更新日期：2019-12-01 00:00:00

abstract：:High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of the intervertebral disc. Indeed, the osmoadaptive transcription factor, nuclear factor of activated T-cells 5 (NFAT5 aka TonEBP), is robustly expressed by residen...

journal_title：Developmental biology

authors： Tessier S,Madhu V,Johnson ZI,Shapiro IM,Risbud MV

更新日期：2019-11-15 00:00:00

abstract：:Temporally-regulated maternal RNA translation is essential for embryonic development, with defective degradation resulting in stalled 2-cell embryos. We show that DDX1, a DEAD box protein implicated in RNA transport, may be a key regulator of maternal RNA utilization. DDX1 protein localizes exclusively to cytoplasmic ...

journal_title：Developmental biology

authors： Hildebrandt MR,Wang Y,Li L,Yasmin L,Glubrecht DD,Godbout R

更新日期：2019-11-15 00:00:00

abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

journal_title：Developmental biology

authors： Dasgupta K,Chung JU,Asam K,Jeong J

更新日期：2019-11-15 00:00:00

abstract：:Intestinal tract development is a coordinated process involving signaling among the progenitors and developing cells from all three germ layers. Development of endoderm-derived intestinal epithelium has been shown to depend on epigenetic modifications, but whether that is also the case for intestinal tract cell types ...

journal_title：Developmental biology

authors： Ganz J,Melancon E,Wilson C,Amores A,Batzel P,Strader M,Braasch I,Diba P,Kuhlman JA,Postlethwait JH,Eisen JS

更新日期：2019-11-15 00:00:00

abstract：:The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby b...

journal_title：Developmental biology

authors： Xie B,Morton DB,Cook TA

更新日期：2019-11-01 00:00:00

abstract：:mid and H15 encode Tbx20 transcription factors that specify ventral pattern in the Drosophila leg. We find that there are at least two pathways for mid and H15 specification of ventral fate. In the first pathway, mid and H15 negatively regulate Dpp, the dorsal signal in leg development. mid and H15 block the dorsalizi...

journal_title：Developmental biology

authors： Svendsen PC,Phillips LA,Deshwar AR,Ryu JR,Najand N,Brook WJ

更新日期：2019-11-01 00:00:00

abstract：:The development of asymmetric patterns along biologically relevant axes is a hallmark of many vertebrate organs or structures. One example is the sensory epithelium of the mammalian auditory system. Two distinct types of mechanosensory hair cells (inner and outer) and at least six types of associated supporting cells ...

journal_title：Developmental biology

authors： Ellis K,Driver EC,Okano T,Lemons A,Kelley MW

更新日期：2019-09-15 00:00:00

abstract：:The molecular and cellular mechanism for clearance of dead neurons was explored in the developing Drosophila optic lobe. During development of the optic lobe, many neural cells die through apoptosis, and corpses are immediately removed in the early pupal stage. Most of the cells that die in the optic lobe are young ne...

journal_title：Developmental biology

authors： Nakano R,Iwamura M,Obikawa A,Togane Y,Hara Y,Fukuhara T,Tomaru M,Takano-Shimizu T,Tsujimura H

更新日期：2019-09-01 00:00:00

abstract：:Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is expressed in mesenchymal cells that associate with the vascular endothelium....

journal_title：Developmental biology

authors： Whitesell TR,Chrystal PW,Ryu JR,Munsie N,Grosse A,French CR,Workentine ML,Li R,Zhu LJ,Waskiewicz A,Lehmann OJ,Lawson ND,Childs SJ

更新日期：2019-09-01 00:00:00