Abstract:
:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and combinations of direct and inverted repeats. In the third-instar larva the Jonah genes are abundantly expressed as transcripts of a single size class, located exclusively in the midgut. The Jonah genes were initially defined by homology to a reference cDNA clone. However, the structural heterogeneity within this gene family is so large that Jonah genes that fail to hybridize to the reference cDNA, yet hybridize to other members of the family that do hybridize to that cDNA have been subsequently identified. These findings raise questions regarding the sharpness of gene family boundaries.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Carlson JR,Hogness DSdoi
10.1016/0012-1606(85)90038-7subject
Has Abstractpub_date
1985-04-01 00:00:00pages
341-54issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(85)90038-7journal_volume
108pub_type
杂志文章abstract::Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...
journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.04.018
更新日期:2009-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.8458
更新日期:1997-02-15 00:00:00
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更新日期:2003-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.10.009
更新日期:2011-01-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9588
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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