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CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.

Abstract：

:In the embryonic mouse retina, retinoic acid (RA) is unevenly distributed along the dorsoventral axis: RA-rich zones in dorsal and ventral retina are separated by a horizontal RA-poor stripe that contains the RA-inactivating enzyme CYP26A1. To explore the developmental role of this arrangement, we studied formation of the retina and its projections in Cyp26a1 null-mutant mice. Expression of several dorsoventral markers was not affected, indicating that CYP26A1 is not required for establishing the dorsoventral retina axis. Analysis of the mutation on a RA-reporter mouse background confirmed, as expected, that the RA-poor stripe was missing in the retina and its projections at the time when the optic axons first grow over the diencephalon. A day later, however, a gap appeared both in retina and retinofugal projections. As explanation, we found that CYP26C1, another RA-degrading enzyme, had emerged centrally in a narrower domain within the RA-poor stripe. While RA applications increased retinal Cyp26a1 expression, they slightly reduced Cyp26c1. These observations indicate that the two enzymes function independently. The safeguard of the RA-poor stripe by two distinct enzymes during later development points to a role in maturation of a significant functional feature like an area of higher visual acuity that develops at its location.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Sakai Y,Luo T,McCaffery P,Hamada H,Dräger UC

doi

10.1016/j.ydbio.2004.08.032

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

143-57

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(04)00588-3

journal_volume

276

pub_type

杂志文章

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