Abstract:
:DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for Notch. In contrast to previously described DSL ligands for Notch, Jagged2 is not widely expressed in the developing central nervous system. However, Jagged2 and Notch1 are coexpressed in the apical ectodermal ridge (AER), suggesting a role for this ligand-receptor pair in limb development. Furthermore, unlike Jagged1, Jagged2 is coexpressed with Notch in the developing thymus, where it may induce Notch signaling to direct T-cell fate. Our data are consistent with the idea that the diversity of cell types regulated by Notch signaling is a consequence of activation of unique Notch isoforms by different DSL ligands.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Shawber C,Boulter J,Lindsell CE,Weinmaster Gdoi
10.1006/dbio.1996.0310subject
Has Abstractpub_date
1996-11-25 00:00:00pages
370-6issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(96)90310-3journal_volume
180pub_type
杂志文章abstract::The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regard...
journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2007-04-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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journal_title:Developmental biology
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pub_type: 杂志文章
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更新日期:1985-06-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0834
更新日期:2002-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0442
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1266
更新日期:1995-09-01 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2008-01-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1997-08-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2000-11-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1984-12-01 00:00:00