Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell.

abstract：:An understanding of heart development is critical in any systems biology approach to cardiovascular disease. The interpretation of data generated from high-throughput technologies (such as microarray and proteomics) is also essential to this approach. However, characterizing the role of genes in the processes underlyi...

journal_title：Developmental biology

authors： Khodiyar VK,Hill DP,Howe D,Berardini TZ,Tweedie S,Talmud PJ,Breckenridge R,Bhattarcharya S,Riley P,Scambler P,Lovering RC

更新日期：2011-06-01 00:00:00

abstract：:Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here,...

journal_title：Developmental biology

authors： Rolo A,Skoglund P,Keller R

更新日期：2009-03-15 00:00:00

abstract：:It has long been hypothesized that in fishes the contents of cortical granules are involved in the hardening of egg envelope following fertilization. We previously purified the egg envelope hardening initiation factor from the exudates released from activated medaka (Oryzias latipes) eggs and tentatively termed this p...

journal_title：Developmental biology

authors： Shibata Y,Iwamatsu T,Suzuki N,Young G,Naruse K,Nagahama Y,Yoshikuni M

更新日期：2012-12-15 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...

journal_title：Developmental biology

authors： Nemoto S,Yamamoto K,Hashimoto N

更新日期：1992-06-01 00:00:00

abstract：:Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the musc...

journal_title：Developmental biology

authors： Kusakabe R,Kuraku S,Kuratani S

更新日期：2011-02-01 00:00:00

abstract：:The relative transcription of three unlinked actin genes of the sea urchin Strongylocentrotus purpuratus was measured in isolated nuclei, at several stages during embryonic development. Transcription of two cytoskeletal actin genes, CyI and CyIIIa, was first detected in 64-128 cell embryos. At the early stages, the Cy...

journal_title：Developmental biology

authors： Hickey RJ,Boshar MF,Crain WR Jr

更新日期：1987-11-01 00:00:00

abstract：:Cellular interactions with laminin are important for numerous morphogenetic events. In Xenopus, the first of these is neurulation. The integrin alpha6 subunit mediates an attachment of the cells of the neural plate to the underlying basal lamina. A disruption of this interaction results in embryos that fail to neurula...

journal_title：Developmental biology

authors： Lallier TE,DeSimone DW

更新日期：2000-09-01 00:00:00

abstract：:During anuran metamorphosis, larval-type myotubes in both trunk and tail are removed by apoptosis, and only trunk muscles are replaced by newly formed adult-type myotubes. In the present study, we clarified the regulatory mechanisms for specific developmental fates of adult and larval muscles. Two distinct (adult and ...

journal_title：Developmental biology

authors： Shimizu-Nishikawa K,Shibota Y,Takei A,Kuroda M,Nishikawa A

更新日期：2002-11-01 00:00:00

abstract：:lilliputian (lilli), the sole Drosophila member of the FMR2/AF4 (Fragile X Mental Retardation/Acute Lymphoblastic Leukemia) family of transcription factors, is widely expressed with roles in segmentation, cellularization, and gastrulation during early embryogenesis with additional distinct roles at later stages of emb...

journal_title：Developmental biology

authors： Vanderzwan-Butler CJ,Prazak LM,Gergen JP

更新日期：2007-01-15 00:00:00

abstract：:Cardiomyocyte differentiation overall has been analyzed in vivo and in vitro at the molecular level by homologous recombination, gene mutation studies, and by transgenics; however, the roles of many signal transduction mechanisms that drive this differentiation process are still not fully understood. One set of signal...

journal_title：Developmental biology

authors： Zhou X,Quann E,Gallicano GI

更新日期：2003-03-15 00:00:00

abstract：:Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...

journal_title：Developmental biology

authors： Stowers RS,Russell S,Garza D

更新日期：1999-09-01 00:00:00

abstract：FOREWORD:The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells mi...

journal_title：Developmental biology

authors： Le Douarin NM,Dupin E

更新日期：2018-12-01 00:00:00

abstract：:Unequal first cleavage is characteristic of a diverse group of protostome animals. In the nematode Caenorhabditis elegans, unequal first cleavage is achieved through the interaction of an apparently symmetric mitotic spindle apparatus with a clearly polarized cell cortex. In the clitellate annelid Tubifex tubifex, by ...

journal_title：Developmental biology

authors： Ren X,Weisblat DA

更新日期：2006-04-01 00:00:00

abstract：:In the developing vertebrate brain, growing axons establish a scaffold of axon tracts connected across the midline via commissures. We have previously identified a population of telencephalic neurons that express NOC-2, a novel glycoform of the neural cell adhesion molecule N-CAM that is involved in axon guidance in t...

journal_title：Developmental biology

authors： Anderson RB,Cooper HM,Jackson SC,Seaman C,Key B

更新日期：2000-01-15 00:00:00

abstract：:Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previous...

journal_title：Developmental biology

authors： Dias Moura Prazeres PH,Sena IFG,Borges IDT,de Azevedo PO,Andreotti JP,de Paiva AE,de Almeida VM,de Paula Guerra DA,Pinheiro Dos Santos GS,Mintz A,Delbono O,Birbrair A

更新日期：2017-07-01 00:00:00

abstract：:Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trime...

journal_title：Developmental biology

authors： Payne C,Braun RE

更新日期：2006-05-15 00:00:00

abstract：:Expression of constitutively active Src protein tyrosine kinase in Xenopus oocytes has been shown to accelerate oocyte maturation suggesting that Src may be involved in meiotic progression. However, meiotic regulation of endogenous Src kinase in oocytes has not been investigated in detail. To address this problem, we ...

journal_title：Developmental biology

authors： Tokmakov A,Iwasaki T,Itakura S,Sato K,Shirouzu M,Fukami Y,Yokoyama S

更新日期：2005-02-15 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:Previous study of the development of the levator ani muscle (LA) revealed that the sex difference in muscle fiber number is under the control of testosterone during the perinatal period. In this study, the development of the LA muscle was examined in both sexes to test the hypothesis that testosterone action determine...

journal_title：Developmental biology

authors： Joubert Y,Tobin C,Lebart MC

更新日期：1994-03-01 00:00:00

abstract：:The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

journal_title：Developmental biology

authors： Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

更新日期：2014-01-15 00:00:00

abstract：:During primary neurogenesis in Xenopus, a cascade of helix--loop--helix (HLH) transcription factors regulates neuronal determination and differentiation. While XNeuroD functions at a late step in this cascade to regulate neuronal differentiation, the factors that carry out terminal differentiation are still unknown. W...

journal_title：Developmental biology

authors： Pozzoli O,Bosetti A,Croci L,Consalez GG,Vetter ML

更新日期：2001-05-15 00:00:00

abstract：:Activin is a potent inducer of axial mesoderm in vitro and may have a similar role in vivo. Xenopus laevis eggs contain significant amounts of activin or activin-like factors, but maternal activin transcripts have not been detected in Xenopus eggs. The maternal activin protein might be translated from activin beta A o...

journal_title：Developmental biology

authors： Rebagliati MR,Dawid IB

更新日期：1993-10-01 00:00:00

abstract：:The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their evolutionary potential. Here we investigate natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic deve...

journal_title：Developmental biology

authors： Jiang P,Ludwig MZ,Kreitman M,Reinitz J

更新日期：2015-09-01 00:00:00

abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

journal_title：Developmental biology

authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

更新日期：1986-11-01 00:00:00

abstract：:5' HoxD genes are required for the correct formation of limb skeletal elements. Hoxd13, the most 5'-located HoxD gene, is important for patterning the most distal limb region, and its mutation causes human limb malformation syndromes. The mechanisms underlying the control of developmental processes by Hoxd13, and by H...

journal_title：Developmental biology

authors： Salsi V,Vigano MA,Cocchiarella F,Mantovani R,Zappavigna V

更新日期：2008-05-15 00:00:00

abstract：:Development of the craniofacial structures requires the precise differentiation of cranial neural crest cells into osteoblasts or chondrocytes. Here, we explore the epigenetic and non-epigenetic mechanisms that are required for the development of craniofacial chondrocytes. We previously demonstrated that the acetyltra...

journal_title：Developmental biology

authors： Pezoa SA,Artinger KB,Niswander LA

更新日期：2020-08-01 00:00:00

abstract：:The ancestral state of animal gastrulation and its bearing for our understanding of bilaterian evolution still is one of the most controversially discussed topics in the field of evolutionary and developmental biology. One hypothesis, the so-called amphistomy scenario, suggests the presence of a slit-like blastopore i...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2017-07-01 00:00:00

abstract：:The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...

journal_title：Developmental biology

authors： Carney TD,Miller MR,Robinson KJ,Bayraktar OA,Osterhout JA,Doe CQ

更新日期：2012-01-01 00:00:00

abstract：:In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found th...

journal_title：Developmental biology

authors： Fischer AJ,Reh TA

更新日期：2000-04-15 00:00:00

abstract：:The changes in the intracellular pH (pHi) of sea urchin sperm associated with motility initiation and acrosome reaction were investigated using uptake of two different probes; 9-aminoacridine and methylamine, as a qualitative index. Sperm suspended in Na+-free sea water were immotile and able to concentrate these amin...

journal_title：Developmental biology

authors： Lee HC,Johnson C,Epel D

更新日期：1983-01-01 00:00:00