The representation of heart development in the gene ontology.

abstract：:A monoclonal antibody (MAb No. 25-16), raised against purified cortical secretory vesicles (CVs) from the eggs of Strongylocentrotus purpuratus, has been used to identify a previously uncharacterized CV-derived polypeptide component of the sea urchin fertilization envelope (FE). MAb No. 25-16, an IgG1, bound to a grou...

journal_title：Developmental biology

authors： Vater CA,Jackson RC

更新日期：1989-03-01 00:00:00

abstract：:Using gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogene...

journal_title：Developmental biology

authors： Murer-Orlando M,Paterson RC,Lok S,Tsui LC,Breitman ML

更新日期：1987-01-01 00:00:00

abstract：:An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...

journal_title：Developmental biology

authors： Litvin J,Montgomery MO,Goldhamer DJ,Emerson CP Jr,Bader DM

更新日期：1993-04-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

journal_title：Developmental biology

authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

更新日期：2018-09-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a complex malignancy with poor prognosis. Several genetic lesions can lead to the disease. One of these corresponds to the NUP98-HOXA9 (NA9) translocation that fuses sequences encoding the N-terminal part of NUP98 to those encoding the DNA-binding domain of HOXA9. Despite several studie...

journal_title：Developmental biology

authors： Baril C,Gavory G,Bidla G,Knævelsrud H,Sauvageau G,Therrien M

更新日期：2017-01-01 00:00:00

abstract：:The ectoderm of early Xenopus gastrula is competent to become induced to neural tissue, but dorsal ectoderm is more neural competent than ventral ectoderm. It is a tenable, but as yet untested possibility that the higher neural competence of dorsal gastrula ectoderm is dependent on the presence of the dorsal mesoderm....

journal_title：Developmental biology

authors： Otte AP,Moon RT

更新日期：1992-07-01 00:00:00

abstract：:We have investigated the ability of growing dictyate oocytes and early preimplantation embryos of the mouse to process extrachromosomal DNA molecules with free ends by intranuclearly microinjecting DNA fragments containing a region of homology of various extent at either the 5' or 3' terminus. Homologous recombination...

journal_title：Developmental biology

authors： Fiorenza MT,Bevilacqua A,Bevilacqua S,Mangia F

更新日期：2001-05-01 00:00:00

abstract：:The forkhead genes encode a transcription factor involved in embryogenesis and pattern formation in multicellular organisms. They are mammalian transcriptional regulators that bind DNA as a monomer through their forkhead domain. The Foxf2 (LUN) mRNA is expressed in the mesenchyme directly adjacent to the ectoderm-deri...

journal_title：Developmental biology

authors： Wang T,Tamakoshi T,Uezato T,Shu F,Kanzaki-Kato N,Fu Y,Koseki H,Yoshida N,Sugiyama T,Miura N

更新日期：2003-07-01 00:00:00

abstract：:We describe the characterization and a functional analysis in Xenopus development of RalB, a small G protein. RalB RNA and protein are detectable during oogenesis and early development, but the gene is expressed only weakly in adult tissues. The RalB transcripts are processed by poly(A) extension during oocyte maturat...

journal_title：Developmental biology

authors： Moreau J,Lebreton S,Iouzalen N,Mechali M

更新日期：1999-05-15 00:00:00

abstract：:The role of angiotensin II (Ang II) in the early embryonic development of the heart has not been examined. We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the Ang II AT1 and AT2 receptors in embryonic day 10.25 Sprague-Dawley rats, and have used confocal microscopy to local...

journal_title：Developmental biology

authors： Price RL,Carver W,Simpson DG,Fu L,Zhao J,Borg TK,Terracio L

更新日期：1997-12-15 00:00:00

abstract：:etv2 is an endothelial-specific ETS transcription factor that is essential for vascular differentiation and morphogenesis in vertebrates. While recent data suggest that Etv2 is dynamically regulated during vascular development, little is known about the mechanisms involved in this process. Here, we find that etv2 tran...

journal_title：Developmental biology

authors： Moore JC,Sheppard-Tindell S,Shestopalov IA,Yamazoe S,Chen JK,Lawson ND

更新日期：2013-12-01 00:00:00

abstract：:In the full grown oocyte of Xenopus laevis, a sodium permeability can be induced by depolarization to positive potential with current injection. Voltage-clamp analysis has shown that depolarization causes a long-lasting modification of the membrane during which voltage-gated sodium channels become functional. In the p...

journal_title：Developmental biology

authors： Baud C

更新日期：1983-10-01 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:We determined expression and function of a cell membrane protein in the developing chick retinotectal system identified by a monoclonal antibody (mAb 4H5) and the corresponding antiserum. Our data revealed that the protein shares a series of properties, including the N-terminal amino acid sequence, with a cell adhesio...

journal_title：Developmental biology

authors： Pollerberg GE,Mack TG

更新日期：1994-10-01 00:00:00

abstract：:Chondrogenesis of mesenchymal cells from the frontonasal mass, mandibles and maxillae of stage-24 chick embryos has been investigated in micromass (high-density) cultures. Distinct differences in the amount and pattern of cartilage differentiation are found. In cultures of frontonasal mass cells, a central sheet of ca...

journal_title：Developmental biology

authors： Wedden SE,Lewin-Smith MR,Tickle C

更新日期：1986-09-01 00:00:00

abstract：:PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated ...

journal_title：Developmental biology

authors： Ohlsson R,Falck P,Hellström M,Lindahl P,Boström H,Franklin G,Ahrlund-Richter L,Pollard J,Soriano P,Betsholtz C

更新日期：1999-08-01 00:00:00

abstract：:The rise of evolutionary developmental biology was not the progressive isolation and characterization of developmental genes and gene networks. Many obstacles had to be overcome: the idea that all genes were more or less involved in development; the evidence that developmental processes in insects had nothing in commo...

journal_title：Developmental biology

authors： Morange M

更新日期：2011-09-01 00:00:00

abstract：:The members of the transforming growth factor-beta (TGF-beta) superfamily are secreted proteins that interact with cell-surface receptors to elicit signals that regulate a variety of biological processes during vertebrate embryogenesis. Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family rece...

journal_title：Developmental biology

authors： Mishina Y,Crombie R,Bradley A,Behringer RR

更新日期：1999-09-15 00:00:00

abstract：:The formation and maintenance of the highly regular organization of membrane systems and proteins in striated muscle require specific membrane-membrane and membrane-cytoskeleton interactions. The development of T-tubules and sarcoplasmic reticulum (SR) was followed in gastrocnemius muscle fibers from chicken embryos b...

journal_title：Developmental biology

authors： Flucher BE,Takekura H,Franzini-Armstrong C

更新日期：1993-11-01 00:00:00

abstract：:Tubes with distinct shapes and sizes are critical for the proper function of many tubular organs. Here we describe a unique phenotype caused by the loss of a novel, evolutionarily-conserved, Drosophila Smad-like protein, Expansion. In expansion mutants, unicellular and intracellular tracheal branches develop bubble-li...

journal_title：Developmental biology

authors： Iordanou E,Chandran RR,Yang Y,Essak M,Blackstone N,Jiang L

更新日期：2014-09-01 00:00:00

abstract：:5' HoxD genes are required for the correct formation of limb skeletal elements. Hoxd13, the most 5'-located HoxD gene, is important for patterning the most distal limb region, and its mutation causes human limb malformation syndromes. The mechanisms underlying the control of developmental processes by Hoxd13, and by H...

journal_title：Developmental biology

authors： Salsi V,Vigano MA,Cocchiarella F,Mantovani R,Zappavigna V

更新日期：2008-05-15 00:00:00

abstract：:Serotonin is a classical small-molecule neurotransmitter with known effects on developmental processes. Previous studies have shown a developmental role for serotonin in the fly peripheral nervous system. In this study, we show that serotonin can modulate the development of serotonergic varicosities within the fly cen...

journal_title：Developmental biology

authors： Sykes PA,Condron BG

更新日期：2005-10-01 00:00:00

abstract：:The earliest muscle in zebrafish arises from iterated sets of two to six cells in each somite, the muscle pioneers (MP). MP develop synchronously in young trunk myotomes adjacent to the notochord, precisely where the horizontal myoseptum will form. They elongate without cell fusion and differentiate hours earlier than...

journal_title：Developmental biology

authors： Felsenfeld AL,Curry M,Kimmel CB

更新日期：1991-11-01 00:00:00

abstract：:In a previous study, we demonstrated trophic effects of vitamin A and its active metabolite, retinoic acid (RA), on perinatal rat spinal cord neurons and astrocytes in vitro. We now report that RA increases the survival of cholinergic neurons without affecting that of GABAergic neurons. These results were supported by...

journal_title：Developmental biology

authors： Wuarin L,Sidell N

更新日期：1991-04-01 00:00:00

abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

journal_title：Developmental biology

authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

更新日期：2014-06-15 00:00:00

abstract：:We examined the structure, expression, and possible functions of a nanos homologue during gametogenesis and blastogenesis in the colonial ascidian Botryllus primigenus. An approximately 1.3-kb-long cDNA was cloned; it was termed BpNos since the deduced amino acid sequence (288 aa) contained 2 Nanos-like CCHC zinc fing...

journal_title：Developmental biology

authors： Sunanaga T,Satoh M,Kawamura K

更新日期：2008-12-01 00:00:00

abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

journal_title：Developmental biology

authors： Bell J,Char BR,Maxson R

更新日期：1992-04-01 00:00:00

abstract：:Developmental patterning and growth of the vertebrate digestive and respiratory tracts requires interactions between the epithelial endoderm and adjacent mesoderm. The esophagus is a specialized structure that connects the digestive and respiratory systems and its normal development is critical for both. Shh signaling...

journal_title：Developmental biology

authors： Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

更新日期：2011-11-15 00:00:00

abstract：:In mouse chimeras with parthenogenetic cell contribution, the skeletal musculature appears to be largely devoid of parthenogenetically derived cells. To analyze the appearance and early distribution of myotomal cells in parthenotes, we determined the expression of the muscle-specific transcription factors myogenin, MY...

journal_title：Developmental biology

authors： Fundele R,Bober E,Arnold HH,Grim M,Bender R,Wilting J,Christ B

更新日期：1994-01-01 00:00:00

abstract：:Pax3/7 paired homeodomain transcription factors are important markers of muscle stem cells. Pax3 is required upstream of myod for lateral dermomyotomal cells in the amniote somite to form particular muscle cells. Later Pax3/7-dependent cells generate satellite cells and most body muscle. Here we analyse early myogenes...

journal_title：Developmental biology

authors： Hammond CL,Hinits Y,Osborn DP,Minchin JE,Tettamanti G,Hughes SM

更新日期：2007-02-15 00:00:00