Abstract：
:Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trimethylated, and all three modification states have been identified in different nuclear domains. Correlation of these methylated histone states to different stages of cell differentiation, however, is not extensive. Mammalian spermatogenesis is a developmental process ideal for studying the epigenetic control of differentiation. Maintenance of spermatogonial stem cells requires the transcriptional repressor Plzf, but a role for histone methylation has not been established. Here we show that Plzf-expressing spermatogonia completely lack monomethyl-H3-K27 and monomethyl-H4-K20, and contain very little monomethyl-H3-K9. Dimethylated H3-K27 and H4-K20 are detected as punctate foci in Plzf-positive cells, but dimethyl-H3-K9 is absent. Trimethylated H3-K9 and H4-K20 exhibit a unique perinuclear distribution that coincides with Plzf expression, localizing to punctate foci in more differentiated spermatogonia. Loss of Plzf correlates with increased punctate distribution of trimethylated H3-K9 and H4-K20 at the expense of perinuclear localization. These data signify the possible importance of different histone lysine methylation states in the epigenetic control of spermatogenesis.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Payne C,Braun REdoi
10.1016/j.ydbio.2006.02.013subject
Has Abstractpub_date
2006-05-15 00:00:00pages
461-72issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(06)00114-Xjournal_volume
293pub_type
杂志文章abstract：:Although mitogen-activated protein kinase (MAPK) is a well-known cell cycle regulator, emerging studies have also implicated its activity in the regulation of intracellular calcium concentration ([Ca2+](i)) and secretion. Those studies raise the hypothesis that MAPK activity during oocyte maturation and early fertiliz...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.03.029
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journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1995.1015
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ydbio.2003.09.003
更新日期：2003-12-15 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/0012-1606(84)90271-9
更新日期：1984-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2014-02-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1986-06-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1986-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
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更新日期：2020-04-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2006-12-15 00:00:00
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pub_type： 杂志文章
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更新日期：1986-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1987-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2004-10-01 00:00:00
