Isolation of two Drosophila melanogaster genes abundantly expressed in the ovary during vitelline membrane synthesis.

abstract：:Hedgehog (Hh) proteins and cAMP-dependent protein kinase A (PKA) generally play opposing roles in developmental patterning events. Humans and mice heterozygous for mutations in the sonic hedgehog (Shh) receptor gene patched-1 (ptc1) have an increased incidence of certain types of cancer, including medulloblastoma (MB)...

journal_title：Developmental biology

authors： Lelievre V,Seksenyan A,Nobuta H,Yong WH,Chhith S,Niewiadomski P,Cohen JR,Dong H,Flores A,Liau LM,Kornblum HI,Scott MP,Waschek JA

更新日期：2008-01-01 00:00:00

abstract：:Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under cont...

journal_title：Developmental biology

authors： Perl AK,Hokuto I,Impagnatiello MA,Christofori G,Whitsett JA

更新日期：2003-06-01 00:00:00

abstract：:The Toll signaling pathway functions in several Drosophila processes, including dorsal-ventral pattern formation and the immune response. Here, we demonstrate that this pathway is required in the epidermis for proper muscle development. Previously, we showed that the zygotic Toll protein is necessary for normal muscle...

journal_title：Developmental biology

authors： Halfon MS,Keshishian H

更新日期：1998-07-01 00:00:00

abstract：:Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

journal_title：Developmental biology

authors： Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

更新日期：2009-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a complex malignancy with poor prognosis. Several genetic lesions can lead to the disease. One of these corresponds to the NUP98-HOXA9 (NA9) translocation that fuses sequences encoding the N-terminal part of NUP98 to those encoding the DNA-binding domain of HOXA9. Despite several studie...

journal_title：Developmental biology

authors： Baril C,Gavory G,Bidla G,Knævelsrud H,Sauvageau G,Therrien M

更新日期：2017-01-01 00:00:00

abstract：:Extracellular cAMP induces the intracellular synthesis and subsequent secretion of cAMP in Dictyostelium discoideum (relay). cAMP relay was strongly diminished in mutant HB3 which shows abnormal development by making very small fruiting bodies. Extracellular cAMP binds to receptors on the surface of mutant cells and i...

journal_title：Developmental biology

authors： Kesbeke F,Van Haastert PJ

更新日期：1988-12-01 00:00:00

abstract：:Lineage analysis studies in the avian embryo have identified two types of smooth muscle cells (SMCs) in the tunica media of large elastic arteries; one that originates within the cardiac neural crest and is ectoderm in origin (Ect) and another that arises from local mesenchyme of mesodermal origin (Mes). To determine ...

journal_title：Developmental biology

authors： Topouzis S,Majesky MW

更新日期：1996-09-15 00:00:00

abstract：:Vitelline coats (VCs) of Phallusia mammillata were isolated and purified following homogenization of live eggs in order to investigate the molecular basis of sperm-egg recognition. Clean VCs were partly solubilized by sonication in H2O and the soluble fraction (SFVC), derived from the outer surface of VCs, was used fo...

journal_title：Developmental biology

authors： Litscher E,Honegger TG

更新日期：1991-12-01 00:00:00

abstract：:Much of boundary formation during development remains to be understood, despite being a defining feature of many animal taxa. Axial patterning of Hydra, a member of the ancient phylum Cnidaria which diverged prior to the bilaterian radiation, involves a steady-state of production and loss of tissue, and is dependent o...

journal_title：Developmental biology

authors： López-Quintero JA,Torres GG,Neme R,Bosch TCG

更新日期：2020-02-15 00:00:00

abstract：:Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1(tm1(cre)Skm)), in which the Foxg1 coding region was replaced by the Cre gene....

journal_title：Developmental biology

authors： Kawaguchi D,Sahara S,Zembrzycki A,O'Leary DDM

更新日期：2016-04-01 00:00:00

abstract：:The first step in the development of the Drosophila optic medullar primordia is the expansion of symmetrically dividing neuroepithelial cells (NEs); this step is then followed by the appearance of asymmetrically dividing neuroblasts (NBs). However, the mechanisms responsible for the change from NEs to NBs remain uncle...

journal_title：Developmental biology

authors： Orihara-Ono M,Toriya M,Nakao K,Okano H

更新日期：2011-03-01 00:00:00

abstract：:In the mouse embryo, the onset of zygotic transcription occurs at the end of the first cell cycle, upon completion of DNA replication. We show that the nonhistone chromosomal protein HMG-I, whose translocation into the pronuclei of one-cell embryos is linked to this first round of DNA synthesis, plays a critical role ...

journal_title：Developmental biology

authors： Beaujean N,Bouniol-Baly C,Monod C,Kissa K,Jullien D,Aulner N,Amirand C,Debey P,Käs E

更新日期：2000-05-15 00:00:00

abstract：:The origin of the avian cardiovascular system from the primitive streak has been mapped by the construction of quail/chick transplantation chimeras, the use of QH-1 (an antiquail endothelial/endocardial cell marker), and injections of a vital fluorescent dye (DiI) into the primitive streak. Our studies reveal that the...

journal_title：Developmental biology

authors： Garcia-Martinez V,Schoenwolf GC

更新日期：1993-10-01 00:00:00

abstract：:The HNK-1 antibody recognizes a carbohydrate moiety that is shared by a family of cell adhesion molecules and is also present on the surface of migrating neural crest cells. Here, the effects of the HNK-1 antibody on neural crest cells were examined in vitro and in vivo. When the HNK-1 antibody was added to neural tub...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1987-10-01 00:00:00

abstract：:Gap junctions are intercellular channels made of connexins (Cxs) that allow direct communication between adjacent cells. Modulation of Cxs has been associated with abnormal development and function of the mammary gland and breast cancer. However, the mechanisms underlying their expression during normal mammary gland a...

journal_title：Developmental biology

authors： Dianati E,Poiraud J,Weber-Ouellette A,Plante I

更新日期：2016-08-01 00:00:00

abstract：:Ooplasmic segregation in the late interphase zygote of the leech Theromyzon trizonare is accomplished by reorganization of an ectoplasmic cytoskeleton formed by polar rings and meridional bands. The dynamic properties of this cytoskeleton were explored by time-lapse confocal and video microscopy. Cytoskeleton assembly...

journal_title：Developmental biology

authors： Fernández J,Toro J,Ubilla A

更新日期：2004-07-01 00:00:00

abstract：:Using two different models of pregnancy failure in mice, we show in this communication that preimplantation embryonic development can be controlled, in vivo, with cytokines. In one model, described by us previously, CSF-1 is shown to block gestations in plugged females due to its induction of defective early developme...

journal_title：Developmental biology

authors： Tartakovsky B,Ben-Yair E

更新日期：1991-08-01 00:00:00

abstract：:Early spermatids contain roughly 1000-fold more TATA-binding protein (TBP) mRNA than do somatic cells. The appearance of TBP-overexpressing spermatids in the developing testis is accompanied by a large increase in whole-organ levels of total RNA and of poly(A)+ RNA per cell. Whereas somatic cells initiate transcriptio...

journal_title：Developmental biology

authors： Schmidt EE,Schibler U

更新日期：1997-04-01 00:00:00

abstract：:The polypeptide labeling patterns of somatic cells, gonidia (asexual reproductive cells), embryos, and juvenile spheroids of Volvox carteri cultures synchronized by a light/dark cycle were studied as a function of developmental stage and incubation condition. Specimens were exposed to 35SO=4 for 1-hr periods at select...

journal_title：Developmental biology

authors： Kirk DL,Kirk MM

更新日期：1983-04-01 00:00:00

abstract：:Inhibitor of differentiation and DNA-binding (Id) proteins, Id1 to Id4, function in the regulation of cellular proliferation and differentiation. Id proteins have been shown to interact with bHLH proteins and other proteins involved in regulating cellular proliferation and differentiation, suggesting a widespread regu...

journal_title：Developmental biology

authors： Sakamoto S,Tateya T,Omori K,Kageyama R

更新日期：2020-04-15 00:00:00

abstract：:In Dictyostelium discoideum cyclic AMP (cAMP) metabolism during macrocyst development, i.e., the sexual cycle of this organism, and in giant cells, i.e., fusion products from opposite mating-type cells, was investigated. The pattern of change in cAMP levels during macrocyst development differed considerably from that ...

journal_title：Developmental biology

authors： Abe K,Orii H,Okada Y,Saga Y,Yanagisawa K

更新日期：1984-08-01 00:00:00

abstract：:The egg activation process functions to implement developmental programs that act much later in embryogenesis. One example of this is the fact that application of protein tyrosine kinase inhibitors to the fertilized sea urchin egg for a 15-min period results in a defect in the gastrulation process occurring over 24 h ...

journal_title：Developmental biology

authors： Livingston BT,VanWinkle CE,Kinsey WH

更新日期：1998-01-01 00:00:00

abstract：:Hox genes are highly conserved segmental identity genes well known for their complex expression patterns and divergent targets. Here we present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode. We have ut...

journal_title：Developmental biology

authors： Teng Y,Girard L,Ferreira HB,Sternberg PW,Emmons SW

更新日期：2004-12-15 00:00:00

abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

journal_title：Developmental biology

authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

更新日期：2000-01-01 00:00:00

abstract：:Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trime...

journal_title：Developmental biology

authors： Payne C,Braun RE

更新日期：2006-05-15 00:00:00

abstract：:The mammalian kidney collecting ducts are critical for water, electrolyte and acid-base homeostasis and develop as a branched network of tubular structures composed of principal cells intermingled with intercalated cells. The intermingled nature of the different collecting duct cell types has made it challenging to id...

journal_title：Developmental biology

authors： Grassmeyer J,Mukherjee M,deRiso J,Hettinger C,Bailey M,Sinha S,Visvader JE,Zhao H,Fogarty E,Surendran K

更新日期：2017-04-01 00:00:00

abstract：:beta-Catenin was originally identified biochemically as a protein that binds E-cadherin in cultured cells and that interaction was later shown to be essential for cadherin function. Independently, armadillo, the beta-catenin homolog in Drosophila melanogaster, was identified as a segment polarity gene necessary for th...

journal_title：Developmental biology

authors： Miller JR,McClay DR

更新日期：1997-12-15 00:00:00

abstract：:We studied the pathway of 5S ribosomal RNA (rRNA) during oogenesis in Xenopus from its storage in the cytoplasm to incorporation into ribosomes in the nucleus. Ribonucleoprotein particle (RNP) assembly assays reveal striking differences in the behavior of oocyte-type and somatic-type 5S rRNA after microinjection into ...

journal_title：Developmental biology

authors： Allison LA,North MT,Neville LA

更新日期：1995-04-01 00:00:00

abstract：:The developmental events of sporulation and fruiting body formation in the prokaryote Myxococcus xanthus are preceded by a stage of massive cell death. Two phenotypically complementable strains of M. xanthus defective in developmental lysis were identified from a group of conditional sporulation mutants. Mixture of th...

journal_title：Developmental biology

authors： Janssen GR,Dworkin M

更新日期：1985-11-01 00:00:00

abstract：:In Drosophila, the RNA helicase VASA (VAS) is required for both germ line formation and oocyte differentiation. While the murine VAS homologue is required for spermatogenesis, it is dispensable for germ line formation. The molecular basis for this apparently dual role of VAS in germ line ontogeny is, however, unclear....

journal_title：Developmental biology

authors： Krøvel AV,Olsen LC

更新日期：2004-07-01 00:00:00