A novel cyclic AMP metabolism exhibited by giant cells and its possible role in the sexual development of Dictyostelium discoideum.

abstract：:Cell adhesion molecules (CAMs) perform numerous functions during neural development. An individual CAM can play different roles during each stage of neuronal differentiation; however, little is known about how such functional switching is accomplished. Here we show that Drosophila N-cadherin (CadN) is required at mult...

journal_title：Developmental biology

authors： Kurusu M,Katsuki T,Zinn K,Suzuki E

更新日期：2012-06-15 00:00:00

abstract：:The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic ...

journal_title：Developmental biology

authors： Wada H,Ghysen A,Satou C,Higashijima S,Kawakami K,Hamaguchi S,Sakaizumi M

更新日期：2010-04-15 00:00:00

abstract：:Developmental pattern formation allows cells within a tissue or organ to coordinate their development and establish cell types in relationship to one another. To better characterize the developmental patterning events within one organ, the C. elegans hindgut, we have analyzed the expression pattern of several genes us...

journal_title：Developmental biology

authors： Sewell ST,Zhang G,Uttam A,Chamberlin HM

更新日期：2003-10-01 00:00:00

abstract：:In Xenopus, the hatching and cement glands form at important boundaries in the head. We have examined induction of these glands in order to see the basis for this ectodermal patterning. Ectoderm can be induced to form hatching and cement glands by dorsal mesoderm and by the neural plate. Because the neural plate is su...

journal_title：Developmental biology

authors： Drysdale TA,Elinson RP

更新日期：1993-07-01 00:00:00

abstract：:Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not presen...

journal_title：Developmental biology

authors： Andersson O,Reissmann E,Jörnvall H,Ibáñez CF

更新日期：2006-05-15 00:00:00

abstract：:In the zebrafish embryo, cells fated to give rise to the rostral brain move in a concerted fashion and retain tissue coherence during morphogenesis. We demonstrate here that Otx proteins have a dramatic effect on cell-cell interactions when expressed ectopically in the zebrafish embryo. Injection of zebrafish Otx1 or ...

journal_title：Developmental biology

authors： Bellipanni G,Murakami T,Doerre OG,Andermann P,Weinberg ES

更新日期：2000-07-15 00:00:00

abstract：:The Drosophila salivary gland is a simple tubular organ derived from a contiguous epithelial primordium, which is established by the activities of the homeodomain-containing proteins Sex combs reduced (SCR), Extradenticle (EXD), and Homothorax (HTH). EGF signaling along the ventral midline specifies the salivary duct ...

journal_title：Developmental biology

authors： Haberman AS,Isaac DD,Andrew DJ

更新日期：2003-06-15 00:00:00

abstract：:Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the musc...

journal_title：Developmental biology

authors： Kusakabe R,Kuraku S,Kuratani S

更新日期：2011-02-01 00:00:00

abstract：:The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...

journal_title：Developmental biology

authors： Thomsen MK,Butler CM,Shen MM,Swain A

更新日期：2008-04-15 00:00:00

abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

journal_title：Developmental biology

authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

更新日期：2004-10-15 00:00:00

abstract：:Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for t...

journal_title：Developmental biology

authors： Leonard M,Zhang L,Zhai N,Cader A,Chan Y,Nowak RB,Fowler VM,Menko AS

更新日期：2011-01-15 00:00:00

abstract：:To examine the conditions of cell composition necessary for formation of a complete tadpole, defect embryos of 35 series were prepared by removing particular cells from 16- and 32-cell embryos of Xenopus laevis. These defect embryos were cultured and their development was examined. Formation of a complete tadpole did ...

journal_title：Developmental biology

authors： Kageura H

更新日期：1995-08-01 00:00:00

abstract：:Coordinated locomotion of Drosophila larvae depends on accurate patterning and stable attachment to the cuticle of both muscles and proprioceptors (chordotonal organs). Unlike muscle spindles in mammals, the fly chordotonal organs are not embedded in the body-wall muscles. Yet, the contractile system (muscles and tend...

journal_title：Developmental biology

authors： Klein Y,Halachmi N,Egoz-Matia N,Toder M,Salzberg A

更新日期：2010-01-15 00:00:00

abstract：:The formation and maintenance of the highly regular organization of membrane systems and proteins in striated muscle require specific membrane-membrane and membrane-cytoskeleton interactions. The development of T-tubules and sarcoplasmic reticulum (SR) was followed in gastrocnemius muscle fibers from chicken embryos b...

journal_title：Developmental biology

authors： Flucher BE,Takekura H,Franzini-Armstrong C

更新日期：1993-11-01 00:00:00

abstract：:Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with th...

journal_title：Developmental biology

authors： Suzuki D,Yamada A,Amano T,Yasuhara R,Kimura A,Sakahara M,Tsumaki N,Takeda S,Tamura M,Nakamura M,Wada N,Nohno T,Shiroishi T,Aiba A,Kamijo R

更新日期：2009-11-15 00:00:00

abstract：:The self-organizing tissue-based approach coupled with induced pluripotent stem (iPS) cell technology is evolving as a promising field for designing organoids in culture and is expected to achieve valuable practical outcomes in regenerative medicine and drug development. Organoids show properties of functional organs ...

journal_title：Developmental biology

authors： Shinozawa T,Yoshikawa HY,Takebe T

更新日期：2016-12-15 00:00:00

abstract：:During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell...

journal_title：Developmental biology

authors： Gates J,Nowotarski SH,Yin H,Mahaffey JP,Bridges T,Herrera C,Homem CC,Janody F,Montell DJ,Peifer M

更新日期：2009-09-01 00:00:00

abstract：:Integrins are expressed on the surface of some vertebrate eggs where they are thought to have a role in fertilization. The objective of this study is to determine if integrins are expressed on sea urchin eggs. The alphaB and betaC subunits were cloned using the homology polymerase chain reaction. Monoclonal and polycl...

journal_title：Developmental biology

authors： Murray G,Reed C,Marsden M,Rise M,Wang D,Burke RD

更新日期：2000-11-15 00:00:00

abstract：:The tail ascidian larval peripheral nervous system is made up of epidermal sensory neurons distributed more or less regularly in ventral and dorsal midlines. Their formation occurs in two-steps: the ventral and dorsal midlines are induced as neurogenic territories by Fgf9/16/20 and Admp respectively. The Delta2/Notch ...

journal_title：Developmental biology

authors： Roure A,Darras S

更新日期：2016-01-01 00:00:00

abstract：:Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastr...

journal_title：Developmental biology

authors： Sawyer JM,Harrell JR,Shemer G,Sullivan-Brown J,Roh-Johnson M,Goldstein B

更新日期：2010-05-01 00:00:00

abstract：:The sea urchin sperm receptor isolated from the eggs of Strongylocentrotus purpuratus is a high molecular weight proteoglycan-like molecule. Previous studies in our laboratory suggested that the sperm receptor has two functional components, glycosaminoglycan chains that are responsible for sperm binding and polypeptid...

journal_title：Developmental biology

authors： Ruiz-Bravo N,Lennarz WJ

更新日期：1986-11-01 00:00:00

abstract：:Type II collagen is a major component of cartilage extracellular matrix. Differentiation of mesenchyme into cartilage involves the cessation of type I collagen synthesis and the onset of type II collagen synthesis. Solution hybridization of mRNA isolated from chick limb buds with a cDNA probe to type II collagen mRNA ...

journal_title：Developmental biology

authors： Swalla BJ,Upholt WB,Solursh M

更新日期：1988-01-01 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:To investigate the mechanism by which the hormone 17 alpha,20 beta-dihydroxy-4-pregnen-3-one(17 alpha,20 beta-DP) acts on a receptor on the external surface of rainbow trout oocytes to induce maturation, the interaction between 17 alpha,20 beta-DP receptors and G-proteins was examined. Pertussis toxin (PT) catalyzed t...

journal_title：Developmental biology

authors： Yoshikuni M,Nagahama Y

更新日期：1994-12-01 00:00:00

abstract：:This work describes unknown aspects of chordotonal organ (ChO) morphogenesis revealed in post-embryonic stages through the use of new fluorescently labeled markers. We show that towards the end of embryogenesis a hitherto unnoticed phase of cell migration commences in which the cap cells of the ventral ChOs elongate a...

journal_title：Developmental biology

authors： Halachmi N,Nachman A,Salzberg A

更新日期：2016-03-01 00:00:00

abstract：:Hox genes are thought to participate in patterning the anteroposterior (a-p) axis during vertebrate embryogenesis. In this investigation, the spatial expression of six Hoxb genes was analyzed in early embryos of Xenopus laevis by in situ hybridization. Hoxb gene expression was first detected in late gastrulae/early ne...

journal_title：Developmental biology

authors： Godsave S,Dekker EJ,Holling T,Pannese M,Boncinelli E,Durston A

更新日期：1994-12-01 00:00:00

abstract：:Fertilization results in the tyrosine phosphorylation of several egg proteins within minutes of sperm-egg binding and inhibitor studies have shown that tyrosine kinase activity is required for many aspects of egg activation. The present study demonstrates the presence of p59c-fyn kinase in the sea urchin egg and exami...

journal_title：Developmental biology

authors： Kinsey WH

更新日期：1996-03-15 00:00:00

abstract：:The inactivation of the prolactin receptor gene by homologous recombination has made it possible to investigate the role of prolactin signaling in mammary gland development without resort to ablative surgery of the endocrine glands. In knockout mice lacking the prolactin receptor, mammary development is normal up to p...

journal_title：Developmental biology

authors： Brisken C,Kaur S,Chavarria TE,Binart N,Sutherland RL,Weinberg RA,Kelly PA,Ormandy CJ

更新日期：1999-06-01 00:00:00

abstract：:COUP-TFII (also known as Nr2f2), a member of the nuclear orphan receptor superfamily, is expressed in several regions of the central nervous system (CNS), including the ventral thalamus, hypothalamus, midbrain, pons, and spinal cord. To address the function of COUP-TFII in the CNS, we generated conditional COUP-TFII k...

journal_title：Developmental biology

authors： Kim BJ,Takamoto N,Yan J,Tsai SY,Tsai MJ

更新日期：2009-02-15 00:00:00

abstract：:Immunohistochemical analysis of myosin heavy chain (MHC) isoform expression in perinatal and adult rat diaphragm muscles was performed with antibodies which permitted the identification of all known MHC isoforms found in typical rat muscles. Isoform switching, leading to the emergence of the adult phenotype, was more ...

journal_title：Developmental biology

authors： LaFramboise WA,Daood MJ,Guthrie RD,Schiaffino S,Moretti P,Brozanski B,Ontell MP,Butler-Browne GS,Whalen RG,Ontell M

更新日期：1991-03-01 00:00:00