当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.

Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.

Abstract：

:Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with the latter caused by a complete absence of interdigital programmed cell death. Furthermore, the lack of interdigital programmed cell death and associated syndactyly was related to down-regulated gene expression of Bmp2, Bmp7, Msx1, and Msx2, which are known to promote apoptosis in the interdigital mesenchyme. Our findings from Rac1 conditional mutants indicate crucial roles for Rac1 in limb bud morphogenesis, especially interdigital programmed cell death.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Suzuki D,Yamada A,Amano T,Yasuhara R,Kimura A,Sakahara M,Tsumaki N,Takeda S,Tamura M,Nakamura M,Wada N,Nohno T,Shiroishi T,Aiba A,Kamijo R

doi

10.1016/j.ydbio.2009.09.014

subject

Has Abstract

pub_date

2009-11-15 00:00:00

pages

396-406

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(09)01192-0

journal_volume

335

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility.

    abstract：:The vertebrate intestinal epithelium is renewed continuously from stem cells at the base of the crypt in mammals or base of the fold in fish over the life of the organism. As stem cells divide, newly formed epithelial cells make an initial choice between a secretory or enterocyte fate. This choice has previously been ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.01.013

    authors： Roach G,Heath Wallace R,Cameron A,Emrah Ozel R,Hongay CF,Baral R,Andreescu S,Wallace KN

    更新日期：2013-04-15 00:00:00

  • Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus.

    abstract：:While Wnt signaling is known to be involved in early steps of neural crest development, the mechanism remains unclear. Because Wnt signaling is able to posteriorize anterior neural tissues, neural crest induction by Wnts has been proposed to be an indirect consequence of posteriorization of neural tissues rather than ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.12.016

    authors： Wu J,Yang J,Klein PS

    更新日期：2005-03-01 00:00:00

  • Retarded postimplantation development of X0 mouse embryos: impact of the parental origin of the monosomic X chromosome.

    abstract：:About 12-17% of the embryos obtained by mating mice carrying the In(X)1H or Paf mutations are of the 39,X (X0) genotype. Depending on the mutant mice used for mating, the monosomic X chromosome can be inherited from the paternal (XP) or the maternal (XM) parent. The XP0 embryos display developmental retardation at gas...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8972

    authors： Jamieson RV,Tan SS,Tam PP

    更新日期：1998-09-01 00:00:00

  • Photoreversible inhibition by ultraviolet light of germ line development in Smittia sp. (Chironomidae, Diptera).

    abstract：:Pole cell formation in embryos of the parthenogenetic midge, Smittia sp., can be delayed or inhibited by irradiation of the posterior egg pole with ultraviolet light (uv). This leaves the schedule of nuclear divisions and chromosome eliminations virtually unaffected. However, uv irradiation delays the precocious migra...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90236-1

    authors： von Brunn A,Kalthoff K

    更新日期：1983-12-01 00:00:00

  • Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons.

    abstract：:In the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrinA5 are differentially expressed not only in the tectum, but also in a high-nasal-to-low-temporal pattern in the retina. Recently, we have shown that retrovirally driven overexpression of ephrinA2 on retinal axons leads to topog...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9489

    authors： Dütting D,Handwerker C,Drescher U

    更新日期：1999-12-01 00:00:00

  • Use of a cDNA library for the study of mRNA changes during muscle differentiation.

    abstract：:A cDNA library was used to measure changes in many individual mRNAs during muscle differentiation in culture. A library of 1000 clones was constructed from total myofiber poly(A) RNA. About 23% of these clones gave a detectable colony hybridization signal using end-labeled myofiber mRNA, the remainder containing muscl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90049-0

    authors： Devlin RB,Haskell SG

    更新日期：1983-02-01 00:00:00

  • Developmental and photoregulation of al-1 and al-2, structural genes for two enzymes essential for carotenoid biosynthesis in Neurospora.

    abstract：:The levels of al-1 and al-2 transcripts change dramatically in response to light and development during the formation of Neurospora crassa asexual spores (conidia). al-1 and al-2 mRNAs accumulate throughout conidiation irrespective of lighting conditions initially at low levels. As conidiation proceeds, two increases ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1129

    authors： Li C,Schmidhauser TJ

    更新日期：1995-05-01 00:00:00

  • Extracellular matrix components and testicular peritubular cells influence the rate and pattern of Sertoli cell migration in vitro.

    abstract：:We report the patterns of migration of Sertoli cells plated on specific substrata, and the influences of testicular peritubular cells on these processes. Data presented indicate that while peritubular cells readily spread when explanted onto Type I collagen, Sertoli cells do not. A delay of 4 to 6 days occurs after Se...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90114-4

    authors： Tung PS,Fritz IB

    更新日期：1986-01-01 00:00:00

  • Differential regulation of gamma-crystallin genes during mouse lens development.

    abstract：:Using gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogene...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90227-2

    authors： Murer-Orlando M,Paterson RC,Lok S,Tsui LC,Breitman ML

    更新日期：1987-01-01 00:00:00

  • Translational regulation of the novel haploid-specific transcripts for the c-abl proto-oncogene and a member of the 70 kDa heat-shock protein gene family in the male germ line.

    abstract：:Expression of the c-abl proto-oncogene in the mouse testis is characterized by the production of a unique 4.7-kb transcript present in germ cells that have entered the haploid phase of spermatogenesis. A similar developmental stage specificity of expression is observed for a member of the 70-kDa heat-shock protein (hs...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90222-9

    authors： Zakeri ZF,Ponzetto C,Wolgemuth DJ

    更新日期：1988-02-01 00:00:00

  • Organoid technology for retinal repair.

    abstract：:A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effecti...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.09.028

    authors： Llonch S,Carido M,Ader M

    更新日期：2018-01-15 00:00:00

  • Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.

    abstract：:Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity. We examined the role of Cdc42 and IQGAP1 in establishing the polarity of mouse oocyte and regulation of meiotic and mitotic divisions. We showed that Cdc42 was localized on the microtubules of meiotic and m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.06.039

    authors： Bielak-Zmijewska A,Kolano A,Szczepanska K,Maleszewski M,Borsuk E

    更新日期：2008-10-01 00:00:00

  • Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones.

    abstract：:Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90122-w

    authors： Lukinius A,Ericsson JL,Grimelius L,Korsgren O

    更新日期：1992-10-01 00:00:00

  • Cell movements during the initial phase of gastrulation in the sea urchin embryo.

    abstract：:The morphogenetic processes responsible for the initial phase of gastrulation in sea urchin embryos are not known. Here we report observations of the size and position of clones of cells derived from horseradish peroxidase (HRP)-injected mesomeres and macromeres. The displacement of these clones during the initial pha...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90255-2

    authors： Burke RD,Myers RL,Sexton TL,Jackson C

    更新日期：1991-08-01 00:00:00

  • Hedgehog activity controls opening of the primary mouth.

    abstract：:To feed or breathe, the oral opening must connect with the gut. The foregut and oral tissues converge at the primary mouth, forming the buccopharyngeal membrane (BPM), a bilayer epithelium. Failure to form the opening between gut and mouth has significant ramifications, and many craniofacial disorders have been associ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.09.029

    authors： Tabler JM,Bolger TG,Wallingford J,Liu KJ

    更新日期：2014-12-01 00:00:00

  • Single-cell transcriptome profiling of the Ciona larval brain.

    abstract：:The tadpole-type larva of Ciona has emerged as an intriguing model system for the study of neurodevelopment. The Ciona intestinalis connectome has been recently mapped, revealing the smallest central nervous system (CNS) known in any chordate, with only 177 neurons. This minimal CNS is highly reminiscent of larger CNS...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.09.023

    authors： Sharma S,Wang W,Stolfi A

    更新日期：2019-04-15 00:00:00

  • Asymmetrization of first cleavage by transient disassembly of one spindle pole aster in the leech Helobdella robusta.

    abstract：:Unequal first cleavage is characteristic of a diverse group of protostome animals. In the nematode Caenorhabditis elegans, unequal first cleavage is achieved through the interaction of an apparently symmetric mitotic spindle apparatus with a clearly polarized cell cortex. In the clitellate annelid Tubifex tubifex, by ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.12.049

    authors： Ren X,Weisblat DA

    更新日期：2006-04-01 00:00:00

  • Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.

    abstract：:Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.07.007

    authors： Nishii K,Morimoto S,Minakami R,Miyano Y,Hashizume K,Ohta M,Zhan DY,Lu QW,Shibata Y

    更新日期：2008-10-01 00:00:00

  • Remodeling of the abdominal epithelial monolayer during the larva-pupa-adult transformation of Manduca.

    abstract：:During metamorphosis of insect epithelial monolayers, cells die, divide, and rearrange. In Drosophila undifferentiated diploid cells destined to form the adult cuticle of each abdominal segment segregate early in development from the surrounding polyploid larval epithelial cells of that segment as eight groups of dipl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.03.017

    authors： Nardi JB,Bee CM,Wallace CL

    更新日期：2018-06-01 00:00:00

  • An ECM-bound, PDGF-like growth factor and a TGF-alpha-like growth factor are required for gastrulation and spiculogenesis in the Lytechinus embryo.

    abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.8059

    authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

    更新日期：1995-12-01 00:00:00

  • Exogenous tenascin inhibits mesodermal cell migration during amphibian gastrulation.

    abstract：:We have used amphibian gastrulation as a model system to study the action of the extracellular matrix (ECM) glycoprotein tenascin on mesodermal cell migration. Tenascin function was assayed in vitro during spreading of isolated cells from the dorsal marginal zone (DMZ) and during cell migration from DMZ explants. Plas...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90256-i

    authors： Riou JF,Shi DL,Chiquet M,Boucaut JC

    更新日期：1990-02-01 00:00:00

  • Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development.

    abstract：:Gene transcription mediates many vital aspects of mammalian embryonic development. A comprehensive characterization and analysis of the dynamics of gene transcription in the embryo is therefore likely to provide significant insights into the basic mechanisms of this process. We used microarrays to map transcription in...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.09.036

    authors： Wagner RA,Tabibiazar R,Liao A,Quertermous T

    更新日期：2005-12-15 00:00:00

  • The exon junction complex is required for stem and progenitor cell maintenance in planarians.

    abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.09.010

    authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

    更新日期：2020-01-01 00:00:00

  • SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.

    abstract：:Gastrulation is the first major morphogenetic movement in development and requires dynamic regulation of cell adhesion and the cytoskeleton. Caenorhabditis elegans gastrulation begins with the migration of the two endodermal precursors, Ea and Ep, from the surface of the embryo into the interior. Ea/Ep migration provi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.507

    authors： Grana TM,Cox EA,Lynch AM,Hardin J

    更新日期：2010-08-15 00:00:00

  • On the role of the 200-kDa neurofilament protein at the developing neuromuscular junction.

    abstract：:To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90422-8

    authors： Donahue SP,Wood JG,English AW

    更新日期：1988-11-01 00:00:00

  • Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

    abstract：:Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the regulation of Pax6 pancreatic expression, we have identified a minimal Pax6 pancreatic enhancer and show that it contains a composite binding site for Meis and Pbx homeop...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.06.030

    authors： Zhang X,Rowan S,Yue Y,Heaney S,Pan Y,Brendolan A,Selleri L,Maas RL

    更新日期：2006-12-15 00:00:00

  • Immunohistochemical characterization of delta crystallin-containing retina/optic nerve "boundary" cells in the chick embryo.

    abstract：:The term "transdifferentiation" has been used to describe the apparent phenotypic conversion of chick embryo neural retina Müller glial cells into lens-like cells in vitro. This phenotypic conversion is characterized by expression of such lens-specific proteins as delta crystallin and has been viewed as an example of ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90186-2

    authors： Linser PJ,Irvin CK

    更新日期：1987-06-01 00:00:00

  • Rhodopsin replacement rescues photoreceptor structure during a critical developmental window.

    abstract：:Rhodopsin is essential for normal photoreceptor development in Drosophila (O'Tousa et al., 1989; Leonard et al., 1992; Kumar and Ready, 1995) and in mice (Humphries et al., 1997). Here we report studies in which a rhodopsin transgene is expressed at restricted stages during the development of Drosophila photoreceptors...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8636

    authors： Kumar JP,Bowman J,O'Tousa JE,Ready DF

    更新日期：1997-08-01 00:00:00

  • Jagged2: a serrate-like gene expressed during rat embryogenesis.

    abstract：:DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0310

    authors： Shawber C,Boulter J,Lindsell CE,Weinmaster G

    更新日期：1996-11-25 00:00:00

  • Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest.

    abstract：:Pigment cells of the zebrafish, Danio rerio, offer an exceptionally tractable system for studying the genetic and cellular bases of cell fate decisions. In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores and black melanophores. I...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.04.023

    authors： Curran K,Lister JA,Kunkel GR,Prendergast A,Parichy DM,Raible DW

    更新日期：2010-08-01 00:00:00