当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Expression and interaction of muscle-related genes in the lamprey imply the evolutionary scenario for vertebrate skeletal muscle, in association with the acquisition of the neck and fins.

Expression and interaction of muscle-related genes in the lamprey imply the evolutionary scenario for vertebrate skeletal muscle, in association with the acquisition of the neck and fins.

Abstract：

:Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the muscle associated with the tongue and the neck. Many of these muscles are derived from several rostral somites, specifically from their hypaxial myotomic domains. However, it has not been clarified how the complicated morphology of these muscles was acquired in the evolution of vertebrates. Here we describe the expression of lamprey homologs of transcription factor genes, including a myogenic regulatory factor of the Myod family (MRF), Pax3/7, Lbx, and Zic, which play important roles in the development of ep-/hypaxial somitic muscles in gnathostomes, and show that the ventral portion of lamprey somites is comparable to the ventral dermomyotome in gnathostomes. The supra- and infraoptic muscles, derived from the two anterior somites in the lamprey, are molecularly specified before their extensive invasion into the head region. Of these, the infraoptic myotomes are suggested to represent the cucullaris homologue in the lamprey based on their topographical position in the embryonic pattern. Slightly caudal myotomes in the lamprey give rise to the hypobranchial muscle, the developmental homologue of the gnathostome hypobranchial musculature. The dorsal moieties of the lamprey somites express a Zic gene, which in teleosts specifies the epaxial identities of the somites. These evidences suggest that, although the myotomes in the ancestral jawless vertebrates do not exhibit ep-/hypaxial distinction at the morphological level, their dorsoventral specification would have already been present at gene regulatory levels, prior to the cyclostome-gnathostome divergence, which may have functioned as the key innovation to establish the ep-/hypaxial distinction in gnathostomes.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Kusakabe R,Kuraku S,Kuratani S

doi

10.1016/j.ydbio.2010.10.029

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

217-27

issue

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(10)01149-8

journal_volume

350

pub_type

杂志文章

在线工具

Expression and interaction of muscle-related genes in the lamprey imply the evolutionary scenario for vertebrate skeletal muscle, in association with the acquisition of the neck and fins.