当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Emergence of the mature myosin phenotype in the rat diaphragm muscle.

Emergence of the mature myosin phenotype in the rat diaphragm muscle.

Abstract：

:Immunohistochemical analysis of myosin heavy chain (MHC) isoform expression in perinatal and adult rat diaphragm muscles was performed with antibodies which permitted the identification of all known MHC isoforms found in typical rat muscles. Isoform switching, leading to the emergence of the adult phenotype, was more complex than had been previously described. As many as four isoforms could be coexpressed in a single myofiber. Elimination of developmental isoforms did not usually result in the myofiber immediately achieving its adult phenotype. Activation of genes for specific adult isoforms might be delayed to puberty. For example, two of the three fast MHCs, MHC2X and MHC2A appeared perinatally, while MHC2B did not appear until 30 days postnatal. By Day 60 this isoform was present in approximately 27% of the myofibers, but in most myofibers expression of this isoform was transient (i.e., at Day greater than or equal to 115, less than 4% of the myofibers expressed MHC2B). Fibers which contained MHC beta/slow during the late fetal and early neonatal period coexpressed MHCemb. A marked increase in the frequency of fibers containing MHC beta/slow occurred between 4 and 21 days postnatal. These slow fibers arose from a population of myofibers which expressed MHCemb and MHCneo during their development, and they accounted for the majority of slow fibers found in the adult diaphragm. The adult myosin phenotype of the diaphragm myofibers (as determined with immunocytochemistry, and 5% SDS-PAGE) was not achieved until the rat was greater than or equal to 115 days old.

journal_name

Dev Biol

journal_title

Developmental biology

authors

LaFramboise WA,Daood MJ,Guthrie RD,Schiaffino S,Moretti P,Brozanski B,Ontell MP,Butler-Browne GS,Whalen RG,Ontell M

doi

10.1016/0012-1606(91)90473-g

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

1-15

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(91)90473-G

journal_volume

144

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • SMAD4 is essential for generating subtypes of neurons during cerebellar development.

    abstract：:Cerebellum development involves the coordinated production of multiple neuronal cell types. The cerebellar primordium contains two germinative zones, the rhombic lip (RL) and the ventricular zone (VZ), which generate different types of glutamatergic and GABAergic neurons, respectively. What regulates the specification...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.02.017

    authors： Fernandes M,Antoine M,Hébert JM

    更新日期：2012-05-01 00:00:00

  • Developmental consequences of mutations in the 84B alpha-tubulin gene of Drosophila melanogaster.

    abstract：:Developmental effects of six mutations in the gene encoding the majority of alpha-tubulin in all tissues at all stages of Drosophila melanogaster development have been examined. All six alleles produce at least partially stable alpha 84B protein. In genetic assays, two of these alleles approximate the null condition. ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90211-9

    authors： Matthews KA,Kaufman TC

    更新日期：1987-01-01 00:00:00

  • Changes in intercellular junctions. II. Modulation in embryonic chick liver in vitro by cytosine arabinoside and dexamethasone.

    abstract：:We have used an in vitro model to investigate the relationship between cell proliferation, cell maturation, and intercellular junctional changes that are seen during normal liver development. Chick liver fragments of embryonic stages 21, 28, and 39 were grown in organ culture in Medium 199 with 10% bovine serum albumi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90265-8

    authors： Meyer RA,Overton J

    更新日期：1983-09-01 00:00:00

  • Development of inositol trisphosphate-induced calcium release mechanism during maturation of hamster oocytes.

    abstract：:Mature hamster eggs exhibit repetitive increases in the intracellular Ca2+ concentration ([Ca2+]i) at fertilization, caused by inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release (IICR) from stores. Oscillating Ca2+ rises also occurred in inseminated immature oocytes at the germinal vesicle (GV) stage but the pe...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1059

    authors： Fujiwara T,Nakada K,Shirakawa H,Miyazaki S

    更新日期：1993-03-01 00:00:00

  • Identification of target genes for the Xenopus Hes-related protein XHR1, a prepattern factor specifying the midbrain-hindbrain boundary.

    abstract：:The midbrain-hindbrain boundary (MHB) acts as a local organizer in the development of the CNS in vertebrates. Previously, we identified an MHB-specific bHLH-WRPW transcriptional repressor gene, Xenopus Hes-related 1 (XHR1), which is initially expressed in the presumptive MHB (pre-MHB) region at the early gastrula stag...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.04.020

    authors： Takada H,Hattori D,Kitayama A,Ueno N,Taira M

    更新日期：2005-07-01 00:00:00

  • Induction of cytoplasmic polarity in heterokaryons of mouse 4-cell-stage blastomeres fused with 8-cell- and 16-cell-stage blastomeres.

    abstract：:Cell surface and cytoplasmic polarity is exhibited by the blastomeres of mouse preimplantation embryos following compaction at the 8-cell stage of cleavage. It has been hypothesized that cytoplasmic polarity is initiated by plasma membrane functions of polar blastomeres that are absent from apolar blastomeres. To test...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90433-2

    authors： Wiley LM,Obasaju MF

    更新日期：1988-11-01 00:00:00

  • Changes in the synthesis and intracellular localization of nuclear proteins during embryogenesis in the sea urchin Strongylocentrotus purpuratus.

    abstract：:A rapid, gentle technique is described for the isolation of nuclei from sea urchin embryos. Using this technique, we have analyzed the synthesis and accumulation of nonhistone nuclear proteins during sea urchin development by two-dimensional gel electrophoresis. Most nuclear proteins fall into one of three patterns of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90445-3

    authors： Servetnick MD,Wilt FH

    更新日期：1987-09-01 00:00:00

  • Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain.

    abstract：:Repulsion plays a fundamental role in the establishment of a topographic map of the chick retinotectal projections. This has been highlighted by studies demonstrating the role of opposing gradients of the EphA3 receptor tyrosine kinase on retinal axons and two of its ligands, ephrin-A2 and ephrin-A5, in the tectum. We...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0268

    authors： Marín O,Blanco MJ,Nieto MA

    更新日期：2001-06-15 00:00:00

  • Genome-wide network of regulatory genes for construction of a chordate embryo.

    abstract：:Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physical...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.009

    authors： Shoguchi E,Hamaguchi M,Satoh N

    更新日期：2008-04-15 00:00:00

  • The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs.

    abstract：:Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8975

    authors： Berry DL,Rose CS,Remo BF,Brown DD

    更新日期：1998-11-01 00:00:00

  • Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification.

    abstract：:A protein complex consisting of Mago Nashi and Tsunagi/Y14 is required to establish the major body axes and for the localization of primordial germ cell determinants during Drosophila melanogaster oogenesis. The Mago Nashi:Tsunagi/Y14 heterodimer also serves as the core of the exon junction complex (EJC), a multiprote...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.06.007

    authors： Parma DH,Bennett PE Jr,Boswell RE

    更新日期：2007-08-15 00:00:00

  • Contractile protein isoforms in muscle development.

    abstract：:The contractile proteins of skeletal muscle are often represented by families of very similar isoforms. Protein isoforms can result from the differential expression of multigene families or from multiple transcripts from a single gene via alternative splicing. In many cases the regulatory mechanisms that determine the...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/0012-1606(92)90067-q

    authors： Bandman E

    更新日期：1992-12-01 00:00:00

  • Dissecting Drosophila embryonic brain development using photoactivated gene expression.

    abstract：:The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00220-3

    authors： Robertson K,Mergliano J,Minden JS

    更新日期：2003-08-01 00:00:00

  • The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus.

    abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.05.002

    authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

    更新日期：2011-08-01 00:00:00

  • Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance.

    abstract：:The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ includes taste buds, papilla epithelium and lateral walls that extend into underlying connective tissue to surround a core of lamina propria cells. Fungiform papilla...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.07.022

    authors： Liu HX,Ermilov A,Grachtchouk M,Li L,Gumucio DL,Dlugosz AA,Mistretta CM

    更新日期：2013-10-01 00:00:00

  • Development of the excitation-contraction coupling apparatus in skeletal muscle: association of sarcoplasmic reticulum and transverse tubules with myofibrils.

    abstract：:The formation and maintenance of the highly regular organization of membrane systems and proteins in striated muscle require specific membrane-membrane and membrane-cytoskeleton interactions. The development of T-tubules and sarcoplasmic reticulum (SR) was followed in gastrocnemius muscle fibers from chicken embryos b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1292

    authors： Flucher BE,Takekura H,Franzini-Armstrong C

    更新日期：1993-11-01 00:00:00

  • Separate elements in the 3' untranslated region of the mouse protamine 1 mRNA regulate translational repression and activation during murine spermatogenesis.

    abstract：:The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8705

    authors： Fajardo MA,Haugen HS,Clegg CH,Braun RE

    更新日期：1997-11-01 00:00:00

  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo.

    abstract：:pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00108-8

    authors： Oliveri P,Davidson EH,McClay DR

    更新日期：2003-06-01 00:00:00

  • Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos.

    abstract：:Cadherin-mediated cell-cell interactions are thought to be critical in controlling cell sorting during embryogenesis. Here, we report that chimeric embryos generated with N-cadherin-deficient (N-cadherin(-/-)) embryonic stem cells develop further than embryos completely lacking N-cadherin only when the myocardium cons...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0250

    authors： Kostetskii I,Moore R,Kemler R,Radice GL

    更新日期：2001-06-01 00:00:00

  • Coordinate regulation of the expression of axonal proteins by the axonal microenvironment.

    abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90090-4

    authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

    更新日期：1986-11-01 00:00:00

  • Molecular mechanism of mammary gland involution: An update.

    abstract：:The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.11.002

    authors： Jena MK,Jaswal S,Kumar S,Mohanty AK

    更新日期：2019-01-15 00:00:00

  • Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse.

    abstract：:Early mammalian embryogenesis is controlled by mechanisms governing the balance between pluripotency and differentiation. The expression of early lineage-specific genes can vary significantly between species, with implications for developmental control and stem cell derivation. However, the mechanisms involved in patt...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.008

    authors： Niakan KK,Eggan K

    更新日期：2013-03-01 00:00:00

  • Reduced Abd-B Hox function during kidney development results in lineage infidelity.

    abstract：:Hox genes can function as key drivers of segment identity, with Hox mutations in Drosophila often resulting in dramatic homeotic transformations. In addition, however, they can serve other essential functions. In mammals, the study of Hox gene roles in development is complicated by the presence of four Hox clusters wi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.03.020

    authors： Magella B,Mahoney R,Adam M,Potter SS

    更新日期：2018-06-15 00:00:00

  • Accumulation kinetics of cotton late embryogenesis-abundant mRNAs and storage protein mRNAs: coordinate regulation during embryogenesis and the role of abscisic acid.

    abstract：:The accumulation of total RNA transcripts of 18 late embryo-abundant (Lea) gene families, each encoding two closely related Lea mRNAs, was measured in cotyledon total RNA during embryogenesis and germination of Gossypium hirsutum L. by RNA dot hybridization. Transcript abundance of the three storage protein families w...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90442-8

    authors： Galau GA,Bijaisoradat N,Hughes DW

    更新日期：1987-09-01 00:00:00

  • BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

    abstract：:The mouse prostate gland develops by branching morphogenesis from the urogenital epithelium and mesenchyme. Androgens and developmental factors, including FGF10 and SHH, promote prostate growth (Berman, D.M., Desai, N., Wang, X., Karhadkar, S.S., Reynon, M., Abate-Shen, C., Beachy, P.A., Shen, M.M., 2004. Roles for He...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.08.018

    authors： Grishina IB,Kim SY,Ferrara C,Makarenkova HP,Walden PD

    更新日期：2005-12-15 00:00:00

  • The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits.

    abstract：:Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and relaying sensory perception and participate in the coordination of sensory-motor output. Numerous cellular and molecular mechanisms that underlie neuronal development in both regions of the nervous system are shared. We discuss he...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2016.10.008

    authors： Hernandez-Miranda LR,Müller T,Birchmeier C

    更新日期：2017-12-01 00:00:00

  • Hedgehog signalling is required for maintenance of myf5 and myoD expression and timely terminal differentiation in zebrafish adaxial myogenesis.

    abstract：:Hedgehog proteins have been implicated in the control of myogenesis in the medial vertebrate somite. In the mouse, normal epaxial expression of the myogenic transcription factor gene myf5 is dependent on Sonic hedgehog. Here we examine in zebrafish the interaction between Hedgehog signals, the expression of myoD famil...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0193

    authors： Coutelle O,Blagden CS,Hampson R,Halai C,Rigby PW,Hughes SM

    更新日期：2001-08-01 00:00:00

  • Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues.

    abstract：:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.01.003

    authors： Tremblay KD,Zaret KS

    更新日期：2005-04-01 00:00:00

  • Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle.

    abstract：:The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, de...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.04.010

    authors： Sefton EM,Gallardo M,Kardon G

    更新日期：2018-08-15 00:00:00

  • Positive and negative DNA elements of the Drosophila grimshawi s18 chorion gene assayed in Drosophila melanogaster.

    abstract：:Germ line transformation has been used to map the cis regulatory DNA elements responsible for the precise and evolutionarily stable developmental expression of the s18 chorion gene. Constructs containing chimeric combinations of Drosophila melanogaster and D. grimshawi DNA regions, as well as D. grimshawi sequences al...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90160-i

    authors： Swimmer C,Kashevsky H,Mao G,Kafatos FC

    更新日期：1992-07-01 00:00:00