Inductive events in the patterning of the Xenopus laevis hatching and cement glands, two cell types which delimit head boundaries.

abstract：:During endochondral bone formation, vascular invasion initiates the replacement of avascular cartilage by bone. We demonstrate herein that the cartilage-specific overexpression of VEGF-A(164) in mice results in the hypervascularization of soft connective tissues away from cartilage. Unexpectedly, perichondrial tissue ...

journal_title：Developmental biology

authors： Takimoto A,Nishizaki Y,Hiraki Y,Shukunami C

更新日期：2009-08-15 00:00:00

abstract：:Pronuclear migration and formation of the first mitotic spindle depend upon assembly of a functional zygotic centrosome. For most animals, this involves both paternal and maternal contributions as sperm basal bodies are converted into centrosomes competent for microtubule nucleation through recruitment of egg proteins...

journal_title：Developmental biology

authors： Twomey C,Wattam SL,Pillai MR,Rapley J,Baxter JE,Fry AM

更新日期：2004-01-15 00:00:00

abstract：:During epithelial development cells become polarized along their apical-basal axis and some epithelia also exhibit polarity in the plane of the tissue. Mutations in the gene encoding a Drosophila Pak family serine/threonine kinase, dPak, disrupt the follicular epithelium that covers developing egg chambers during ooge...

journal_title：Developmental biology

authors： Conder R,Yu H,Zahedi B,Harden N

更新日期：2007-05-15 00:00:00

abstract：:Macronuclei of Tetrahymena thermophila contain a typical H1 which has been shown to be missing from micronuclei. Instead, micronuclei contain three unique polypeptides, alpha, beta, and gamma, which are associated with linker regions of micronuclear chromatin. In this report polyclonal antibodies raised against macron...

journal_title：Developmental biology

authors： Chicoine LG,Wenkert D,Richman R,Wiggins JC,Allis CD

更新日期：1985-05-01 00:00:00

abstract：:We report the patterns of migration of Sertoli cells plated on specific substrata, and the influences of testicular peritubular cells on these processes. Data presented indicate that while peritubular cells readily spread when explanted onto Type I collagen, Sertoli cells do not. A delay of 4 to 6 days occurs after Se...

journal_title：Developmental biology

authors： Tung PS,Fritz IB

更新日期：1986-01-01 00:00:00

abstract：:During primary neurogenesis in Xenopus, a cascade of helix--loop--helix (HLH) transcription factors regulates neuronal determination and differentiation. While XNeuroD functions at a late step in this cascade to regulate neuronal differentiation, the factors that carry out terminal differentiation are still unknown. W...

journal_title：Developmental biology

authors： Pozzoli O,Bosetti A,Croci L,Consalez GG,Vetter ML

更新日期：2001-05-15 00:00:00

abstract：:Spore germination is a defined developmental process that marks a critical point in the life cycle of Dictyostelium discoideum. Upon germination the environmental conditions must be conducive to cell growth to ensure survival of emerged amoebae. However, the signal transduction pathways controlling the various aspects...

journal_title：Developmental biology

authors： Zinda MJ,Singleton CK

更新日期：1998-04-15 00:00:00

abstract：:Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

journal_title：Developmental biology

authors： Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

更新日期：1995-06-01 00:00:00

abstract：:We have examined the morphology of fetal rat sympathetic neurons grown in serum-free medium in the absence of nonneuronal cells. Because cell density can affect phenotypic expression in vitro, the morphological analysis was subdivided into the study of isolated neurons (neurons whose somata were at least 150 micron fr...

journal_title：Developmental biology

authors： Bruckenstein DA,Higgins D

更新日期：1988-08-01 00:00:00

abstract：:A protein complex consisting of Mago Nashi and Tsunagi/Y14 is required to establish the major body axes and for the localization of primordial germ cell determinants during Drosophila melanogaster oogenesis. The Mago Nashi:Tsunagi/Y14 heterodimer also serves as the core of the exon junction complex (EJC), a multiprote...

journal_title：Developmental biology

authors： Parma DH,Bennett PE Jr,Boswell RE

更新日期：2007-08-15 00:00:00

abstract：:Soluble N-ethylmalameide-sensitive factor attachment protein receptor (SNARE) proteins are present in mammalian sperm and could be involved in critical membrane fusion events during fertilization, namely the acrosome reaction. Vesicle-associated membrane protein/synaptobrevin, a SNARE on the membrane of a vesicular ca...

journal_title：Developmental biology

authors： Ramalho-Santos J,Moreno RD,Sutovsky P,Chan AW,Hewitson L,Wessel GM,Simerly CR,Schatten G

更新日期：2000-07-01 00:00:00

abstract：:The relationship among neuronal type, position, and time course of development of identified neurons was examined in the zebrafish (Brachydanio rerio). The cells studied, the reticulospinal neurons Mauthner, MiM1, and MiV1, are located within the same small region in the hindbrain, differ stereotypically in their posi...

journal_title：Developmental biology

authors： Mendelson B

更新日期：1985-12-01 00:00:00

abstract：:Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...

journal_title：Developmental biology

authors： Lilly MA,de Cuevas M,Spradling AC

更新日期：2000-02-01 00:00:00

abstract：:The mammalian Cul4 genes, Cul4A and Cul4B, encode the scaffold components of the cullin-based E3 ubiquitin ligases. The two Cul4 genes are functionally redundant. Recent study indicated that mice expressing a truncated CUL4A that fails to interact with its functional partner ROC1 exhibit no developmental phenotype. We...

journal_title：Developmental biology

authors： Kopanja D,Roy N,Stoyanova T,Hess RA,Bagchi S,Raychaudhuri P

更新日期：2011-04-15 00:00:00

abstract：:A glycoprotein from the liver, which shares epitopes with chorion (egg envelope or zona pellucida) glycoproteins, is present only in the spawning female fish, Oryzias latipes, under natural conditions. This spawning female-specific (SF) substance is distinct from vitellogenin but closely resembles a major glycoprotein...

journal_title：Developmental biology

authors： Hamazaki TS,Nagahama Y,Iuchi I,Yamagami K

更新日期：1989-05-01 00:00:00

abstract：:The ubiquitin-proteasome system is essential for intracellular protein degradation, but there are few studies of this system in the extracellular milieu. Recently, we reported that a 70-kDa sperm receptor, HrVC70, on the vitelline coat is ubiquitinated and then degraded by the sperm proteasome during fertilization of ...

journal_title：Developmental biology

authors： Sakai N,Sawada H,Yokosawa H

更新日期：2003-12-01 00:00:00

abstract：:The NCK adaptor proteins are composed entirely of SH3 and SH2 domains and serve as protein interaction bridges for several receptors during signal transduction events. Here we report the molecular and genetic analysis of the Caenorhabditis elegans nck-1 gene. C. elegans nck-1 encodes two isoforms: NCK-1A and a shorter...

journal_title：Developmental biology

authors： Mohamed AM,Chin-Sang ID

更新日期：2011-06-01 00:00:00

abstract：:Recent results have demonstrated the occurrence of mRNA cap methylation in the sea urchin embryo following fertilization. It has been suggested that this methylation event is responsible for the translational activation of maternal histone mRNAs in these embryos. We have used aphidicolin, an effective inhibitor of bot...

journal_title：Developmental biology

authors： Showman RM,Leaf DS,Anstrom JA,Raff RA

更新日期：1987-05-01 00:00:00

abstract：:Caenorhabditis elegans embryonic elongation depends on both epidermal and muscle cells. The hemidesmosome-like junctions, commonly called fibrous organelles (FOs), that attach the epidermis to the extracellular matrix ensure muscle anchoring to the cuticular exoskeleton and play an essential role during elongation. To...

journal_title：Developmental biology

authors： Hetherington S,Gally C,Fritz JA,Polanowska J,Reboul J,Schwab Y,Zahreddine H,Behm C,Labouesse M

更新日期：2011-02-15 00:00:00

abstract：:MHM is a chicken Z chromosome-linked locus that is methylated and transcriptionally silent in male cells, but is hypomethylated and transcribed into a long non-coding RNA in female cells. MHM has been implicated in both localised dosage compensation and sex determination in the chicken embryo, but direct evidence is l...

journal_title：Developmental biology

authors： Roeszler KN,Itman C,Sinclair AH,Smith CA

更新日期：2012-06-15 00:00:00

abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

journal_title：Developmental biology

authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

更新日期：2006-03-01 00:00:00

abstract：:Joint and skeletal development is highly regulated by extracellular matrix (ECM) proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class. Despite the requirement of joint CSPGs for skeletal flexibility and structure, relatively little is understood regarding their role in establishing joint...

journal_title：Developmental biology

authors： Wilson DG,Phamluong K,Lin WY,Barck K,Carano RA,Diehl L,Peterson AS,Martin F,Solloway MJ

更新日期：2012-03-15 00:00:00

abstract：:Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

journal_title：Developmental biology

authors： Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

更新日期：2006-05-15 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...

journal_title：Developmental biology

authors： Wheway G,Abdelhamed Z,Natarajan S,Toomes C,Inglehearn C,Johnson CA

更新日期：2013-05-01 00:00:00

abstract：:The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

journal_title：Developmental biology

authors： Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

更新日期：2014-01-15 00:00:00

abstract：:Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...

journal_title：Developmental biology

authors： Streit A

更新日期：2004-12-01 00:00:00

abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

journal_title：Developmental biology

authors： Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

更新日期：1984-09-01 00:00:00

abstract：:The correct assembly of junction components, such as E-cadherin and beta-catenin, into the zonula adherens is fundamental for the function of epithelia, both in flies and in vertebrates. In C. elegans, however, the cadherin-catenin system is not essential for general adhesion, raising the question as to the genetic ba...

journal_title：Developmental biology

authors： Bossinger O,Klebes A,Segbert C,Theres C,Knust E

更新日期：2001-02-01 00:00:00

abstract：:The four members of the albumin gene family encode the serum transport proteins albumin, alpha-fetoprotein, alpha-albumin, and vitamin D-binding protein. These genes are transcribed primarily in the liver with each having a different pattern of developmental expression. The tight linkage of these genes, particularly t...

journal_title：Developmental biology

authors： Jin L,Long L,Green MA,Spear BT

更新日期：2009-12-15 00:00:00

abstract：:The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

journal_title：Developmental biology

authors： Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

更新日期：2019-12-01 00:00:00