Abstract:
:Extracellular cAMP induces the intracellular synthesis and subsequent secretion of cAMP in Dictyostelium discoideum (relay). cAMP relay was strongly diminished in mutant HB3 which shows abnormal development by making very small fruiting bodies. Extracellular cAMP binds to receptors on the surface of mutant cells and induces the rapid activation of adenylate cyclase. Intracellular cAMP rises to a concentration as high as that in wild-type cells but only a very small amount of cAMP is secreted. cAMP secretion in wild-type cells starts immediately after cAMP production, and is proportional to the intracellular cAMP concentration. In the mutant cells cAMP secretion starts a few minutes after cAMP production; by that time most of the intracellular cAMP is already degraded by phosphodiesterase and little cAMP is available for secretion. We conclude that mutant HB3 has a defect in the mechanism by which Dictyostelium cells secrete cAMP.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Kesbeke F,Van Haastert PJdoi
10.1016/0012-1606(88)90342-9subject
Has Abstractpub_date
1988-12-01 00:00:00pages
464-70issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(88)90342-9journal_volume
130pub_type
杂志文章abstract::The molting cycle in insects is regulated by the fluctuating levels of ecdysteroids. Twenty-four hours prior to the pupal molt in Manduca sexta steroid titers are relatively high and they fall to very low levels at 4 hr before the molt. Several physiological events accompanying molts have been shown to require the ris...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1115
更新日期:1994-04-01 00:00:00
abstract:UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.10.002
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1183
更新日期:1993-07-01 00:00:00
abstract::To investigate the molecular regulation of embryonic somite formation and development, we have cloned the full-length cDNA and characterized the embryonic expression profile of chicken Paraxis, a member of a novel family of basic helix-loop-helix (bHLH) proteins, which has been suggested to play a role in paraxial mes...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8663
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0254
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90235-u
更新日期:1991-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1351
更新日期:1994-12-01 00:00:00
abstract::Biomineralization, the biologically controlled formation of mineral deposits, is of widespread importance in biology, medicine, and engineering. Mineralized structures are found in most metazoan phyla and often have supportive, protective, or feeding functions. Among deuterostomes, only echinoderms and vertebrates pro...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.07.047
更新日期:2006-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90384-7
更新日期:1985-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.01.006
更新日期:2009-03-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.09.017
更新日期:2021-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.04.468
更新日期:2006-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.08.026
更新日期:2008-11-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9271
更新日期:1999-06-01 00:00:00
abstract::To identify guanine nucleotide binding proteins (G-proteins) in sea urchin eggs and to investigate their role in signal transduction at fertilization, we used cholera toxin (CTX) and pertussis toxin (PTX), which catalyze the specific ADP-ribosylation of G-proteins. Cell surface complex, consisting of plasma membranes ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90260-0
更新日期:1987-04-01 00:00:00
abstract::The fertilization potential in Phallusia mammillata consisted of an initial rapid depolarization. This initial sperm-triggered depolarization was followed by a phase of membrane depolarization which was of either long or short duration, depending on the eggs. When of long duration, the phase of membrane depolarization...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90108-s
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.04.004
更新日期:2009-06-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.11.038
更新日期:2008-03-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.11.022
更新日期:2010-01-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0199
更新日期:1996-08-25 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90047-7
更新日期:1983-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90194-6
更新日期:1986-04-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90089-l
更新日期:1991-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90473-g
更新日期:1991-03-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0321
更新日期:1996-12-15 00:00:00
abstract::A cDNA of the sea urchin Strongylocentrotus purpuratus was identified as encoding polyubiquitin and used to detect a single gene with transcripts containing multiple ubiquitin coding units. Polyubiquitin transcripts exist as a 3.2-kb RNA in polyribosomes and as three higher molecular weight RNAs in purified nuclei. Th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90124-l
更新日期:1991-06-01 00:00:00