Sexual dimorphic expression pattern of a splice variant of zebrafish vasa during gonadal development.

abstract：:In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...

journal_title：Developmental biology

authors： Ikegami R,Hunter P,Yager TD

更新日期：1999-05-15 00:00:00

abstract：:To examine whether the extracellular matrix (ECM) plays a role in mediating interactions between the apical ectodermal ridge (AER) and the subjacent mesoderm in the chick wing bud, we used immunohistochemistry to locate the following tissue components during wing morphogenesis: types I and IV collagens, fibronectin, t...

journal_title：Developmental biology

authors： Critchlow MA,Hinchliffe JR

更新日期：1994-05-01 00:00:00

abstract：:GDF11, a new member of the TGF-beta gene superfamily, regulates anterior/posterior patterning in the axial skeleton during mouse embryogenesis. Gdf11 null mice display skeletal abnormalities that appear to represent anterior homeotic transformations of vertebrae consistent with high levels of Gdf11 expression in...

journal_title：Developmental biology

authors： Gamer LW,Cox KA,Small C,Rosen V

更新日期：2001-01-15 00:00:00

abstract：:Controlled organismal growth to an appropriate adult size requires a regulated balance between nutrient resources, feeding behavior and growth rate. Defects can result in decreased survival and/or reproductive capability. Since Drosophila adults do not grow larger after eclosion, timing of feeding cessation during the...

journal_title：Developmental biology

authors： Wegman LJ,Ainsley JA,Johnson WA

更新日期：2010-09-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

journal_title：Developmental biology

authors： Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

更新日期：2013-04-15 00:00:00

abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

journal_title：Developmental biology

authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

更新日期：1986-11-01 00:00:00

abstract：:The levels of al-1 and al-2 transcripts change dramatically in response to light and development during the formation of Neurospora crassa asexual spores (conidia). al-1 and al-2 mRNAs accumulate throughout conidiation irrespective of lighting conditions initially at low levels. As conidiation proceeds, two increases ...

journal_title：Developmental biology

authors： Li C,Schmidhauser TJ

更新日期：1995-05-01 00:00:00

abstract：:The cranial neural crest (CNC) is a highly motile and multipotent embryonic cell population, which migrates directionally on defined routes throughout the embryo, contributing to facial structures including cartilage, bone and ganglia. Cadherin-mediated cell-cell adhesion is known to play a crucial role in the directi...

journal_title：Developmental biology

authors： Huang C,Kratzer MC,Wedlich D,Kashef J

更新日期：2016-03-15 00:00:00

abstract：:Myotendinous junctions (MTJs) are specialized sites at the surface of muscle fibers where force is transmitted between muscle and tendon. Morphogenesis of MTJs in the latter half of embryonic chick development is characterized by formation of basement membrane, appearance of subsarcolemmal densities, association of my...

journal_title：Developmental biology

authors： Tidball JG

更新日期：1994-06-01 00:00:00

abstract：:RNA localization is tightly coordinated with RNA stability and translation control. Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors are part of a Drosophila transport machinery that localizes mRNAs to specific cellular regions during oogenesis and embryogenesis. We identified the Poly(A)-binding p...

journal_title：Developmental biology

authors： Vazquez-Pianzola P,Urlaub H,Suter B

更新日期：2011-09-15 00:00:00

abstract：:Fibronectin (Fn) plays an important part in the branching morphogenesis of salivary gland, lung, and kidney. Here, we examine the effect of the conditional knockout of Fn in the mammary epithelium [Fn(MEp-/-)] on postnatal mammary gland development, using Cre-loxP-mediated gene knockout technology. Our data show that ...

journal_title：Developmental biology

authors： Liu K,Cheng L,Flesken-Nikitin A,Huang L,Nikitin AY,Pauli BU

更新日期：2010-10-01 00:00:00

abstract：:Epithelial-mesenchymal interactions are of major importance during development to direct correct differentiation and morphogenesis of embryonic tissues. One subset of lateral mesoderm-derived mesenchymal cells will form the smooth muscle (SM) layer of the primary epithelial lining of hollow internal organs. It has bee...

journal_title：Developmental biology

authors： Saint-Jeannet JP,Thiery JP,Koteliansky VE

更新日期：1994-08-01 00:00:00

abstract：:Immunocytochemical studies were performed to determine if denervated rodent iris produces nerve growth factor (NGF) in a form chemically similar to that of the 7S NGF complex in mouse submandibular glands. Antisera to the alpha, beta, and gamma subunits of 7S NGF were raised in rabbits and characterized on immunoblots...

journal_title：Developmental biology

authors： Murphy RA,Landis SC,Bernanke J,Siminoski K

更新日期：1986-04-01 00:00:00

abstract：:Fertilization overcomes meiotic arrest by triggering a series of biochemical events, resulting in activation of the egg. A small group of protein tyrosine kinases (PTKs) have been identified in eggs of invertebrates and lower vertebrates and inhibitor studies have suggested that they play a role in late events of egg ...

journal_title：Developmental biology

authors： Talmor A,Kinsey WH,Shalgi R

更新日期：1998-02-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:Cytotrophoblasts are specialized epithelial cells of the human placenta that differentiate to acquire tumor-like properties that allow them to invade the uterus. Concurrently, they develop endothelial-like characteristics. This transformation allows cytotrophoblasts to replace the maternal cells that line uterine vess...

journal_title：Developmental biology

authors： Zhou Y,Bellingard V,Feng KT,McMaster M,Fisher SJ

更新日期：2003-11-01 00:00:00

abstract：:During epithelial development cells become polarized along their apical-basal axis and some epithelia also exhibit polarity in the plane of the tissue. Mutations in the gene encoding a Drosophila Pak family serine/threonine kinase, dPak, disrupt the follicular epithelium that covers developing egg chambers during ooge...

journal_title：Developmental biology

authors： Conder R,Yu H,Zahedi B,Harden N

更新日期：2007-05-15 00:00:00

abstract：:BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here w...

journal_title：Developmental biology

authors： Davis S,Miura S,Hill C,Mishina Y,Klingensmith J

更新日期：2004-06-01 00:00:00

abstract：:Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

journal_title：Developmental biology

authors： Kelsh RN,Schmid B,Eisen JS

更新日期：2000-09-15 00:00:00

abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

journal_title：Developmental biology

authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

更新日期：2015-06-15 00:00:00

abstract：:The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, ...

journal_title：Developmental biology

authors： Lilla JN,Werb Z

更新日期：2010-01-01 00:00:00

abstract：:We have identified a cellular efflux pump, RhT, with the properties of an MDR transporter-a type of ATP-binding cassette transporter whose substrates include small hydrophobic molecules. RhT transports rhodamine 123 (Rh123) and is inhibited by low temperature, energy poisons, and several MDR transport inhibitors, such...

journal_title：Developmental biology

authors： Good JR,Kuspa A

更新日期：2000-04-01 00:00:00

abstract：:After induction and specification in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves its original territory through a delamination process. Soon afterwards, the NC cells migrate throughout the embryo and colonize a myriad of tissues and organs where they settle and differentiat...

journal_title：Developmental biology

authors： Theveneau E,Mayor R

更新日期：2012-06-01 00:00:00

abstract：:The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...

journal_title：Developmental biology

authors： Jursnich VA,Fraser SE,Held LI Jr,Ryerse J,Bryant PJ

更新日期：1990-08-01 00:00:00

abstract：:The nervous system development of the sea cucumber Stichopus japonicus was investigated to explore the development of the bilateral larval nervous system into the pentaradial adult form typical of echinoderms. The first nerve cells were detected in the apical region of epidermis in the late gastrula. In the auriculari...

journal_title：Developmental biology

authors： Nakano H,Murabe N,Amemiya S,Nakajima Y

更新日期：2006-04-01 00:00:00

abstract：:In embryos of Patella vulgata at the 32-cell stage, one of the four vegetally located macromeres makes contacts with overlying animal micromeres. As a result, this macromere (designated 3D) divides significantly later than the other macromeres and forms the mesodermal stem cell 4d. Shortly before and during this inter...

journal_title：Developmental biology

authors： Kühtreiber WM,van Dongen CA

更新日期：1989-04-01 00:00:00

abstract：:Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...

journal_title：Developmental biology

authors： Lukinius A,Ericsson JL,Grimelius L,Korsgren O

更新日期：1992-10-01 00:00:00

abstract：:We have performed a detailed analysis of the expression pattern of the three gnathostome Otx classes in order to gain new insights into their functional evolution. Expression patterns were examined in the developing eye of a chondrichthyan, the dogfish, and an amniote, the chick, and compared with the capacity of para...

journal_title：Developmental biology

authors： Plouhinec JL,Leconte L,Sauka-Spengler T,Bovolenta P,Mazan S,Saule S

更新日期：2005-02-15 00:00:00

abstract：:A careful reanalysis of the literature indicates that the initial mechanism of activation in sea urchin eggs is remarkably similar to the mechanism established in medaka eggs: i.e., sea urchin eggs are activated by a qualitatively and quantitatively similar calcium explosion; one which is propagated in a wave sustaine...

journal_title：Developmental biology

authors： Jaffe LF

更新日期：1983-10-01 00:00:00

abstract：:During the development of locomotion circuits it is essential that motoneurons with distinct subtype identities select the correct trajectories and target muscles. In vertebrates, the generation of motoneurons and myelinating glia depends on Olig2, one of the five Olig family bHLH transcription factors. We investigate...

journal_title：Developmental biology

authors： Oyallon J,Apitz H,Miguel-Aliaga I,Timofeev K,Ferreira L,Salecker I

更新日期：2012-09-15 00:00:00