Abstract:
:A careful reanalysis of the literature indicates that the initial mechanism of activation in sea urchin eggs is remarkably similar to the mechanism established in medaka eggs: i.e., sea urchin eggs are activated by a qualitatively and quantitatively similar calcium explosion; one which is propagated in a wave sustained by the calcium-stimulated release of calcium from internal sources. These sources are probably in the endoplasmic reticulum. An exhaustive survey of the literature reveals that a wide variety of other activating eggs in the vertebrate line also exhibit secretory waves which are propagated at about 10 microns/sec, and can thus be assumed to reflect the same basic mechanism. Activating protostome eggs on the other hand do not exhibit such waves. This and other systematic differences from deuterostomes suggest that unlike deuterostome eggs, protostome eggs are primarily activated by calcium ions which enter the cytosol from the medium, and do so in response to depolarization of the egg's plasma membrane.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Jaffe LFdoi
10.1016/0012-1606(83)90276-2subject
Has Abstractpub_date
1983-10-01 00:00:00pages
265-76issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(83)90276-2journal_volume
99pub_type
杂志文章,评审abstract::A new monoclonal antibody, specific to an epitope in the carboxyl terminus of the Drosophila collagen IV molecule (basement membrane collagen) was identified. The distributions of collagen IV, laminin, and an additional extracellular molecule, the 2G2 antigen (2G2-Ag), were followed immunocytochemically during early w...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1068
更新日期:1995-03-01 00:00:00
abstract::Temperature sex determining species offer a model for investigating how environmental cues become integrated to the regulation of patterning genes and growth, among bipotential gonads. Manipulation of steroid hormones has revealed the important role of aromatase in the regulation of the estrogen levels involved in tem...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.05.022
更新日期:2015-12-01 00:00:00
abstract::Previous work has documented the importance of BMPs in eye development. Loss-of-function studies in mice, with targeted deletions in either the Bmp7 or Bmp4 genes, have shown that these molecules are critical for early eye development. On the basis of the asymmetry in the dorsal-ventral expression patterns of several ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(02)00115-x
更新日期:2003-04-01 00:00:00
abstract::There has been a resurgence of interest in comparative embryology. It is now important to be able to compare gene expression in different species at similar developmental stages. One phenomenon which may make it difficult to compare embryos in this way is heterochrony--a change in developmental timing during evolution...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1006/dbio.1995.8041
更新日期:1995-12-01 00:00:00
abstract::The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90090-6
更新日期:1990-08-01 00:00:00
abstract::High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of the intervertebral disc. Indeed, the osmoadaptive transcription factor, nuclear factor of activated T-cells 5 (NFAT5 aka TonEBP), is robustly expressed by residen...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.07.004
更新日期:2019-11-15 00:00:00
abstract::Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated mRNAs from a target...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.06.003
更新日期:2017-06-15 00:00:00
abstract::Changes in gene regulatory networks are a major engine for creating developmental novelty during evolution. Conversely, regulatory linkages that survive for very long evolutionary periods might be characteristic of ancient and abstract functions of fundamental utility to all metazoans. The proneural genes, which encod...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.03.004
更新日期:2005-05-15 00:00:00
abstract::The processes of myelination remain incompletely understood but are of profound biomedical importance owing to the several dysmyelinating and demyelinating disorders known in humans. Here, we analyze the zebrafish puma mutant, isolated originally for pigment pattern defects limited to the adult stage. We show that pum...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.07.035
更新日期:2010-10-15 00:00:00
abstract::Pole cell formation in embryos of the parthenogenetic midge, Smittia sp., can be delayed or inhibited by irradiation of the posterior egg pole with ultraviolet light (uv). This leaves the schedule of nuclear divisions and chromosome eliminations virtually unaffected. However, uv irradiation delays the precocious migra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90236-1
更新日期:1983-12-01 00:00:00
abstract::The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90277-x
更新日期:1984-09-01 00:00:00
abstract::The effect of epidermal growth factor (EGF) on cellular differentiation of the neonatal mouse mandibular incisor was examined autoradiographically using tritiated thymidine ([3H]TDR) and tritiated proline ([3H]PRO). On days 0 (day of birth), 1, and 2, EGF was administered (3 micrograms/g body wt) sc to neonates. Mice ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90506-9
更新日期:1987-12-01 00:00:00
abstract::Epi 1, a monoclonal antibody, was generated against an epidermal specific epithelial antigen; it does not stain neural epithelium. We have used Epi 1 as a marker to determine when the spatial patterns delineating neural from nonneural epithelium become established. We used ventral ectoderm in a sandwich assay to show ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90307-2
更新日期:1989-05-01 00:00:00
abstract::During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8570
更新日期:1997-05-15 00:00:00
abstract::Cultured cells obtained from developing chick heart valvular and septal primordial tissues (cardiac cushions) and myocardium were tested for their capacity to bind, internalize, and degrade hyaluronate. A presumptive lysosomal hyaluronidase capable of hyaluronate degradation has been previously isolated and partially ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90234-3
更新日期:1984-12-01 00:00:00
abstract::How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila. JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.09.017
更新日期:2021-01-01 00:00:00
abstract::Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9570
更新日期:2000-02-01 00:00:00
abstract::Cardiac neural crest cells undergo extensive cell rearrangements during the formation of the aorticopulmonary septum in the outflow tract. However, the morphogenetic mechanisms involved in this fundamental process remain poorly understood. To determine the function of the Ca2+-dependent cell adhesion molecule, N-cadhe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.09.003
更新日期:2006-11-15 00:00:00
abstract::We have investigated the ability of growing dictyate oocytes and early preimplantation embryos of the mouse to process extrachromosomal DNA molecules with free ends by intranuclearly microinjecting DNA fragments containing a region of homology of various extent at either the 5' or 3' terminus. Homologous recombination...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0199
更新日期:2001-05-01 00:00:00
abstract::Joint and skeletal development is highly regulated by extracellular matrix (ECM) proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class. Despite the requirement of joint CSPGs for skeletal flexibility and structure, relatively little is understood regarding their role in establishing joint...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.01.005
更新日期:2012-03-15 00:00:00
abstract::The regulation of Sertoli cell transferrin and sulfated glycoprotein-2 (SGP-2) mRNA levels by vitamin A was studied in vitamin A deficient rats. Vitamin A deficiency differentially affected the levels of these mRNAs. Sertoli cells from vitamin A deficient rats contained 3-fold less transferrin mRNA and 1.8-fold more S...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90167-9
更新日期:1987-06-01 00:00:00
abstract::Sex-determination in Caenorhabditis elegans requires regulation of gene transcription and protein activity and stability. sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determination factors. Loss of sel-10 results in a mild masculinizatio...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.07.035
更新日期:2008-10-15 00:00:00
abstract::Cranial nerves VII, IX and X provide both gustatory (taste) and non-gustatory (touch, pain, temperature) innervation to the oral cavity of vertebrates. Gustatory neurons innervate taste buds and project centrally to the rostral nucleus of the solitary tract (NTS), whereas neurons providing general epithelial innervati...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.07.042
更新日期:2007-10-15 00:00:00
abstract::Completion of cytokinesis, abscission, has been studied little despite the intensive studies of the onset and contractile mechanism of the earlier phases of division. It has been well documented that microtubule (MT) disruption before furrow stimulation prevents furrowing, while MT disruption after furrow stimulation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9395
更新日期:1999-10-01 00:00:00
abstract::Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.01.015
更新日期:2008-04-15 00:00:00
abstract::The tail ascidian larval peripheral nervous system is made up of epidermal sensory neurons distributed more or less regularly in ventral and dorsal midlines. Their formation occurs in two-steps: the ventral and dorsal midlines are induced as neurogenic territories by Fgf9/16/20 and Admp respectively. The Delta2/Notch ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.11.009
更新日期:2016-01-01 00:00:00
abstract::Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.03.010
更新日期:2006-07-01 00:00:00
abstract::Dictyostelium discoideum amoebas display colonial multicellularity where starving amoebas aggregate to form migrating slugs and fruiting bodies consisting of spores and three supporting cell types. To resolve the cell signalling mechanism that control sporulation, we use insertional mutagenesis of amoebas transformed ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.04.017
更新日期:2019-08-15 00:00:00
abstract::To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(89)80009-0
更新日期:1989-02-01 00:00:00
abstract::We examined the development of epithelial Na+ conductance in 6- and 7-day post coitus (p.c.) preimplantation rabbit embryos using the whole-cell patch-clamp technique on dissociated rabbit trophectodermal cells and by immunocytochemical localization using a polyclonal antibody directed against subunits of an apical ep...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90289-f
更新日期:1991-10-01 00:00:00