Cyclin A associates with the fusome during germline cyst formation in the Drosophila ovary.

abstract：:In this study, we present evidence that neurogenic cells inhibit the differentiation of cardiogenic cells. When cells of the entire area pellucida at stage 5 were dissociated and reaggregated, the aggregates differentiated into neural tissues and other structures of any germ layer origin, except for heart tissues, des...

journal_title：Developmental biology

authors： Climent S,Sarasa M,Villar JM,Murillo-Ferrol NL

更新日期：1995-09-01 00:00:00

abstract：:COUP-TFII (also known as Nr2f2), a member of the nuclear orphan receptor superfamily, is expressed in several regions of the central nervous system (CNS), including the ventral thalamus, hypothalamus, midbrain, pons, and spinal cord. To address the function of COUP-TFII in the CNS, we generated conditional COUP-TFII k...

journal_title：Developmental biology

authors： Kim BJ,Takamoto N,Yan J,Tsai SY,Tsai MJ

更新日期：2009-02-15 00:00:00

abstract：:The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...

journal_title：Developmental biology

authors： Jursnich VA,Fraser SE,Held LI Jr,Ryerse J,Bryant PJ

更新日期：1990-08-01 00:00:00

abstract：:The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...

journal_title：Developmental biology

authors： Jena MK,Jaswal S,Kumar S,Mohanty AK

更新日期：2019-01-15 00:00:00

abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

journal_title：Developmental biology

authors： Pinset C,Whalen RG

更新日期：1984-04-01 00:00:00

abstract：:Previous studies from this laboratory (M. Bronner-Fraser (1985). J. Cell Biol. 101, 610) have demonstrated that an antibody to a cell surface receptor complex caused alterations in avian neural crest cell migration. Here, these observations are extended to examine the distribution and persistency of injected antibody,...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1986-10-01 00:00:00

abstract：:Many organisms both undergo dramatic morphological changes during post-embryonic development and also regenerate lost structures, but the roles of epigenetic regulators in such processes are only beginning to be understood. In the present study, the functions of two histone modifiers were examined during metamorphosis...

journal_title：Developmental biology

authors： Chou J,Ferris AC,Chen T,Seok R,Yoon D,Suzuki Y

更新日期：2019-06-01 00:00:00

abstract：:The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their evolutionary potential. Here we investigate natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic deve...

journal_title：Developmental biology

authors： Jiang P,Ludwig MZ,Kreitman M,Reinitz J

更新日期：2015-09-01 00:00:00

abstract：:The embryonic vertebrate heart consists of two epithelia: the myocardium and endothelium, separated by the myocardial basement membrane (MBM). The myocardium has been shown to induce endothelial transformation into prevalvular mesenchyme in a temporally and site restricted manner. Previously, we hypothesized that the ...

journal_title：Developmental biology

authors： Mjaatvedt CH,Markwald RR

更新日期：1989-11-01 00:00:00

abstract：:DNA amplification for two major DNA puffs (II/2B and II/9A) of the fungus fly Sciara coprophila increases steeply from 17 to 19 days after hatching (18 degrees C), resulting in almost 20-fold more DNA at these loci in mature larval salivary glands than in adult tissues. At 19 days after hatching when gene amplificatio...

journal_title：Developmental biology

authors： Wu N,Liang C,DiBartolomeis SM,Smith HS,Gerbi SA

更新日期：1993-11-01 00:00:00

abstract：:The nervous system development of the sea cucumber Stichopus japonicus was investigated to explore the development of the bilateral larval nervous system into the pentaradial adult form typical of echinoderms. The first nerve cells were detected in the apical region of epidermis in the late gastrula. In the auriculari...

journal_title：Developmental biology

authors： Nakano H,Murabe N,Amemiya S,Nakajima Y

更新日期：2006-04-01 00:00:00

abstract：:The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...

journal_title：Developmental biology

authors： Guo S,Wilson SW,Cooke S,Chitnis AB,Driever W,Rosenthal A

更新日期：1999-04-15 00:00:00

abstract：:Neuronal differentiation requires a coordinated intracellular response to diverse extracellular stimuli, but the role of specific signaling mechanisms in regulating this process is still poorly understood. Soluble guanylate cyclases (sGCs), which can be stimulated by diffusible free radical gasses such as nitric oxide...

journal_title：Developmental biology

authors： Wright JW,Schwinof KM,Snyder MA,Copenhaver PF

更新日期：1998-12-01 00:00:00

abstract：:This study was undertaken to determine whether premigratory neural crest cells of the axolotl embryo differentiate autonomously into chromatophores, or whether stimuli from the environment, particularly from the extracellular matrix, are required for this process. Neural crest cells were excised from the dorsal part o...

journal_title：Developmental biology

authors： Perris R,Löfberg J

更新日期：1986-02-01 00:00:00

abstract：:Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...

journal_title：Developmental biology

authors： Shimada IS,Somatilaka BN,Hwang SH,Anderson AG,Shelton JM,Rajaram V,Konopka G,Mukhopadhyay S

更新日期：2019-06-01 00:00:00

abstract：:Interleukin-6 is a member of a class of hormone-like molecules termed cytokines. The actions of IL-6 are highly pleiotropic. In adults IL-6 functions as a major mediator of inflammatory responses as well as inducing the synthesis of acute phase proteins by the liver following infection or injury. Based on in vitro and...

journal_title：Developmental biology

authors： Lee FD

更新日期：1992-06-01 00:00:00

abstract：:The homebox gene Hlxb9, encoding Hb9, exhibits a dual expression profile during pancreatic development. The early expression in the dorsal and ventral pancreatic epithelium is transient and spans from embryonic day (e) 8 to e9-e10, whereas the later expression is confined to differentiating beta-cells as they appear. ...

journal_title：Developmental biology

authors： Li H,Edlund H

更新日期：2001-12-01 00:00:00

abstract：:One function of the Wingless signaling pathway is to determine the naked, cuticle cell fate choice in the trunk epidermis of Drosophila larvae. The zinc finger protein Teashirt binds to the transactivator domain of Armadillo to modulate Wingless signaling output in the embryonic trunk and contributes to the naked cell...

journal_title：Developmental biology

authors： Angelats C,Gallet A,Thérond P,Fasano L,Kerridge S

更新日期：2002-01-01 00:00:00

abstract：:Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastr...

journal_title：Developmental biology

authors： Sawyer JM,Harrell JR,Shemer G,Sullivan-Brown J,Roh-Johnson M,Goldstein B

更新日期：2010-05-01 00:00:00

abstract：:The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression...

journal_title：Developmental biology

authors： Marker PC,Stephan JP,Lee J,Bald L,Mather JP,Cunha GR

更新日期：2001-05-01 00:00:00

abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...

journal_title：Developmental biology

authors： Bonini NM,Leiserson WM,Benzer S

更新日期：1998-04-01 00:00:00

abstract：:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in ...

journal_title：Developmental biology

authors： Ryan KM,Hendren JD,Helander LA,Cripps RM

更新日期：2007-02-15 00:00:00

abstract：:Three dominant second-chromosome rearrangement mutations in Drosophila melanogaster, Aristapedioid1 (Arp), vestigial-Depilate (vgD), and vestigial62 (vg62), result in developmental abnormalities of the bristle sense organs on the notum, abdomen, legs, and wing margin. The bristle abnormalities are associated with over...

journal_title：Developmental biology

authors： Sharp EJ,Martin EC,Adler PN

更新日期：1994-02-01 00:00:00

abstract：:Mesenchymal-epithelial interactions are an important source of information for pattern formation during organogenesis. In the developing excretory system, one of the secreted mesenchymal factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have teste...

journal_title：Developmental biology

authors： Shakya R,Jho EH,Kotka P,Wu Z,Kholodilov N,Burke R,D'Agati V,Costantini F

更新日期：2005-07-01 00:00:00

abstract：:Using DiI fluorescent dextrans, we have created fate maps of the neural plate and early neural tube describing the extent of progenitor cell dispersal and the spatial origin of morphologically distinct neuronal cell types along the dorsoventral axis of the developing chick spinal cord. Nonuniform dispersal and mixing ...

journal_title：Developmental biology

authors： Erskine L,Patel K,Clarke JD

更新日期：1998-07-01 00:00:00

abstract：:Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

journal_title：Developmental biology

authors： Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

更新日期：2006-05-15 00:00:00

abstract：:Cell surface and cytoplasmic polarity is exhibited by the blastomeres of mouse preimplantation embryos following compaction at the 8-cell stage of cleavage. It has been hypothesized that cytoplasmic polarity is initiated by plasma membrane functions of polar blastomeres that are absent from apolar blastomeres. To test...

journal_title：Developmental biology

authors： Wiley LM,Obasaju MF

更新日期：1988-11-01 00:00:00

abstract：:In ascidian embryos, the earliest transcription from the zygotic genome begins between the 8-cell and 16-cell stages. Gata.a, a maternally expressed Gata transcription factor, activates target genes specifically in the animal hemisphere, whereas the complex of β-catenin and Tcf7 antagonizes the activity of Gata.a and ...

journal_title：Developmental biology

authors： Imai KS,Kobayashi K,Kari W,Rothbächer U,Ookubo N,Oda-Ishii I,Satou Y

更新日期：2020-02-15 00:00:00

abstract：:Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an...

journal_title：Developmental biology

authors： Moriyama A,Inohaya K,Maruyama K,Kudo A

更新日期：2010-09-15 00:00:00

abstract：:A fundamental issue during nervous system development is how individual cells are formed from the undefined precursors. Differentiated neurons and glia, two major cell types mediating neuronal function, are acquired from immature precursors via a series of explicit controls exerted by transcription factors such as pro...

journal_title：Developmental biology

authors： Mao H,Lv Z,Ho MS

更新日期：2012-10-01 00:00:00